All issues
Volume 19, Issue 3
Displaying 1-6 of 6 articles from this issue
- |<
- <
- 1
- >
- >|
-
Koichi TAURA, Katsuhiko FUKUSHIMA, Ken SHINZATO, Takashi HARADA, Hirof ...1977 Volume 19 Issue 3 Pages 139-149
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSThe urinary excretion of fibrin-fibrinogen degradation products(FDP) was examined by method of haemagglutination-inhibition test in 84 patients with the renal diseases. The subjects consisted of 51 cases of chronic glomerulo-nephritis, 8 cases of chronic renal failure, and 25 cases of nephrotic syndrome.1. Urinary FDP were found in 20% of patients with chronic glomerulonephritis and in 50% of patients with chronic renal failure. In contrast, urinary FDP most commonly presented in nephrotic patients witn severe glome-rular lesions, but were not found in any of 6 patients of minimal lesions.2. The urinary FDP excretion was correlated with the grade of microhematuria.3, Urinary FDP excretion changenable to renal pathologic process was not paralled to the levels of serum FDP.4. Both urinary FDP and intraglomerular fibrin daposits judged oy immunofuorescense were found in nephrotic patients of proliferative or sclerosing lesions, but not in that of minimal lesions. However there is a little correlation betweeen the extent of intragomerular fibrin deposits and urinary FDP excretion in nephrotic patients of membranous or combined lesions and in the paaients. of chronic glomerulonephritis.5. In nephrotic syndrome, urinary FDP was variable to selectivity of proteinuria than the quantity of urine protein. Among 11 cases of nephrotic patients with urine FDP excretion, 10 cases (91%) had α2-MG inheir urine, and 9 cases (82%) had high levels of trans RIgG (0.2<).6. No significant correlation was recognized between the urinary FDP excretion and plasma fibrinolytic activity or urine activator activity.View full abstractDownload PDF (1528K) -
(II) Effect of acid treatment on immunofluorescent findingsTsune Soda1977 Volume 19 Issue 3 Pages 151-164
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSRenal biopsy section from 41 patients of various renal diseases were examined by the fluorescent antibody technique before and after acid elution procedures in order to evaluate change of deposition of heavy chains (γ and α) and light chains (kappa and lambda) of immunoglobulins. The cryostat sections were treated with 0.02 M citrate buffer at pH 3.2 for 24 hr at room temperature.1) Granular capillary localization of IgG was more sensitive to the acid elution compared with GBM linear localization. The initial linear localization remained almost unchanged following the acid treatment.2) Mesangial deposition of IgG tended to decrease or disappear after after acid elution.3) Granular deposition of membranous nephropathy decreased after acid elution, but not likely to be disapaeared. Granular deposits of SLE are more sensititve to the acid elution compared with those of membranous nephropathy, although the fluorescent pattern were similar between them.4) The bitypic stainning of light chains (kappa and lambda) in some cases resulted in monotypic stainning after acid treatment because of elution of one type of light chains.5) Mechanismus of the responses of localised deposits to the acid treatment were discussed.View full abstractDownload PDF (10643K) -
—Nitrogen Balance and 15N Tracing Study with 15N-urea Administration—A. Saito, A. Yamamoto, K. Shimizu, S. Kawaguchi, K. Maeda, K. Kobayash ...1977 Volume 19 Issue 3 Pages 165-176
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSNitrogen balance and m15N incorporation into plasma protein and m15N excretion into urine by intravenous administration of 1 gm Nm15-urea were studied over 1 to 2 weeks on 7 non-dialysed patients with chronic renal failure and 7 dialysed patients. Four of the 7 non-dialysed patients were taking low protein diet (Group A) and 3 on low protein diet with addition of essential amino acids (Group B). Of the 7 dialysed patients, 2 were on single pass system (Group C), 2 on 30L dialysate supply system with adsorbents (Group D), and 3 on 10L dialysate supply system with adsorbents (Group E) Nitrogen balance of Group A was remarkably negative, -1.71gm/day and Group B, slightly positive, +0.27gm/day. All dialysed patients of Group C, D, and E showed slightly positive balance, +0.51, +0.63, and +0, 30 respectively, The mean of the highest values of the m15N incorporation into plasma protein in Group A was 0.017 atom % excess, whereas a normal adult on normal diet showed no 15N incorporation at all. The values for patients Group C, D, and E were positive of 0.012, 0.025, and 0.014 atom % excess respectively. The results indicate that reutilization of urea nitrogen into protein synthesis is increased not only in non-dialysed patients with chronic renal failure taking low protein diet but also in dialysed patients taking high protein diet.View full abstractDownload PDF (1447K) -
Tomihisa Funyu, Kazuo Nigawara, Kazumi Ohno, Yuji Yagihashi, Asao Kawa ...1977 Volume 19 Issue 3 Pages 177-187
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSIf renin inhibitory effect in plasma is competitive, the apparent Michaelis constant (Km') of renin-substrate reaction can be regarded as one of the parameters of renin inhibitory ability. Based on this concept, we observed the changes of log Km' in dog renal venous and aortic plasma before and after various stimulations of refill release, such as renal arteryl constriction, intravenous injection of a-or β-adre-nergic agonist, and diuretics. Renal venous plasma : In the cases which showed high values of log Km' at initial control period, the values seemed to declined gradually under the stimulations of renin release. Then, in other cases that renin release under the stimulations was not significant, the values were almost in low level through the experiments. Aortic plasma : The changes of of log Km' in aortic plasma did not always coincide with that in renal venous plasma. In a certain case, the values were higher than renal venous level throughout the experiment. Furthermore, in another case, the values seemed to be on the increase under the stimulations, in contrast to the changes in renal venous plasma. From these data, it is assumed that kidney has rather an inactivating function than a produc-tive function of renin inhibitor.View full abstractDownload PDF (1283K) -
Donald W. Seldin1977 Volume 19 Issue 3 Pages 189-195
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSDownload PDF (1136K) -
1977 Volume 19 Issue 3 Pages e1
Published: 1977
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSDownload PDF (18K)
- |<
- <
- 1
- >
- >|