The therapeutic effect of calcitonin in renal osteodystrophy(ROD) is controversial. A nephritogenic glycopeptide (crude glycopeptide : GP) was extracted by the method of Shibata and was injected to rats to get azotemic animals. These rats were divided 1st) normal control group, 2nd) GP control group, without administration of VD derivatives and eel calcitonin derivative(ECT), 3rd) 1α-OH-D
3 group, 4th) 1α-OH-D
3+ECT group, 5th) ECT group, 6th) ECT group with long term administration. In the 1ast group, injection of ECT (250m MRCunit/kg. 3 times/week) was carried out from 120th to 285th day. In 3rd, 4th, and 5th groups, the administration of 1α-OH-D
3 (0.05μg/kg), ECT (250mMRC unit/kg) plus 1α-OH-D
3 (0.05μg/kg), ECT (250mMRCunit/kg) were performed from 230thto 285 th day respectively. Mean BUN in control group was 17, 3±2.5mg/dl, whereas that in 2nd group was 41.8±11.1mg/dl (P, 0.001) at 285th day. Cortical thickness of femur in the control group was 27.4±2.0%, whereas in 2nd, 3rd, 4th, 5th, and 6th group, it was 20.9±3.9% (P<0. 001), 27.5±2.0% (ns), 24.7±4.9% (ns), 24.2±3.3% (ns), 26.3±3.3% (ns) respectively at 285th day. Bone density of femur in the control group was 2.31±0.14mm Aluminum (mm Al), whereas inn the 2nd, 3rd, 4th, 5th and 6th group, it was 1.95±0.14mmAl (P<0.001), 2.20±0.15mmA1 (ns), 2.02± 0.12mmAl (P<0.02), 2.11±0.19mmAl(ns), 2.15±0.18mmAl (ns) respectively at 285th day.Urinary hydroxyproline in the 2nd group was 1904±431μg/day, whereas in the control, 3rd, 4th, 5th, and 6th group, it was 399±85μg/day (P<0.001), 440±67μg/day (P<0.001), 440±242μg/day (P<0.001), 933±424μg/day (P<0.01) 670±117μg/day (P<0.001) respectively at 285 day. The present data suggest that ECT might be effective in protecting ROD in these experimental condition, although curative effect of 1α-OH-D
3 was considered to be more remarkable.
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