巻号一覧
26 巻, 3 号
選択された号の論文の10件中1～10を表示しています
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YASUHITO SUZUKI, KATSUYUKI MATSUI, TAKASHI OITE, FUJIO SHIMIZU, YUTAKA ...1984 年 26 巻 3 号 p. 263-273
発行日: 1984年
公開日: 2011/03/01
ジャーナル フリーThe localization of glomerular fibronectin (FN) was studied by double immunofluorescent microscopy (I. F.) using TRITC or FITC conjugated antibodies against glomerular basement membrane (GBM) and FN in 72 cases of human renal biopsy and in experimental glomerulonephritis (GN) in rats. Increase of glomerular FN was closely associated with mesangial proliferation and duplication of the glomerular capillary wall in membranoproliferative GN (type-1 MPGN), Double I. F. revealed subendothelial localization of FN in type-1 MPGN. A linear distribution of FN in membranous nephropathy had an accentuation on the inner aspect of the GBM. Segmental increase of FN on the GBM was prominent in focal glomerular sclerosis (FGS). The features of the FN localized along the GBM in BSA GN with diffuse capillary immune deposits appeared to resemble those of lupus GN. FN was localized predominantly in the mesangium in non-nephrotic Heymann's GN; however, a capillary localization similar to that in human membranous nephropathy appeared in the subsequent nephrotic period. Pretreatment studies on frozen sections of BSA GN indicated that FN was not localized in the three-dimensional structure of immune deposits.抄録全体を表示PDF形式でダウンロード (8162K) -
YASUHIKO TOMINO, MASAHIKO MIURA, TAKAO SUGA, MASAYUKI ENDOH, YASUO NOM ...1984 年 26 巻 3 号 p. 275-280
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーA study was made on the defibrination of intraglomerular fibrin deposits by urokinase in patients with IgA nephropathy. Renal biopsy specimens were obtained from patients with IgA nephropathy and other glomerular diseases. These specimens were incubated with urokinase and/or fresh plasma obtained from the same patients or healthy adults at 37° for 1 hr in plastic test tubes. The sections were stained with FITC-labelled anti-human fibrinogen antiserum and then examined under a fluorescent microscope. Measurements of the plasminogen, plasmin and α2-plasmin inhibitor levels in the plasma were performed in patients with IgA nephropathy, other glomerular diseases and healthy adults at the time of renal biopsy. Measurements of the serum α1-anti-trypsin and α2-macroglobulin levels were also performed in such patients and healthy adults. It was found that urokinase induced a significant defibrination of the intraglomerular fibrin deposits in patients with IgA nephropathy.抄録全体を表示PDF形式でダウンロード (2374K) -
KENJI MIZUNO1984 年 26 巻 3 号 p. 281-291
発行日: 1984年
公開日: 2011/03/01
ジャーナル フリーHuman urinary angiotensin I-converting enzyme was partially purified by DEAF-cellulose and Sephadex G-200 chromatography. The molecular weight of the enzyme was estimated to be 400, 000, 290, 000 and 40, 000 by Sephadex G-200 gel filtration. These isozymes however showed the same optimal pH (8.3) and temperature (37°), and a similar sensitivity towards various inhibitors. The urinary excretion of converting enzyme was 244.6±227.0 (mean±S.D.) units/day in 31 patients with essential hypertension, 380±177.3 units/day in 5 patients with chronic glomerulonephritis, 324.0 units/day in a patient with renovascular hypertension, 288.5 units/day in a patient with primary aldosteronism, and 229.6±73.9 units/day in 5 normal subjects. There was a significant positive correlation between the enzyme excretion and sodium excretion in hypertensive patients (r=0.701, p<0.001), but no significant relationships were observedd among the excretion of the enzyme, creatinine and potassium, and the plasma renin activity (PRA) and aldosterone concentration (PAC). The urinary converting enzyme was increased by f urosemide and upright posture, significantly correlated with the excreted sodium, but not with the potassium and creatinine excretion, PRA and PAC in hypertensive patients as well as in normal subjects. The urinary angiotensin I-converting enzyme, which may derive from the kidney, plays a possible role in the regulation of sodium excretion in cooperation with the renal kallikreinkinin system in hypertensive patients.抄録全体を表示PDF形式でダウンロード (1415K) -
HARUYOSHI YOSHIDA, ERI MUSO, SHUJI INOUE, FUKUMI FURUKAWA, KEN-ICHI SE ...1984 年 26 巻 3 号 p. 293-300
発行日: 1984年
公開日: 2011/03/01
ジャーナル フリーThe clinical significance of two assays for circulating immune complexes (CIC), solid phase C1q binding assay (SPC1gBA) and solid phase conglutinin binding assay (SPKgBA), were evaluated in terms of the correlation with anti-DNA antibodies, complement levels, general disease activity, and grades of proteinuria in 63 SLE patients. No significant quantitative correlation was observed between the two tests for CIC, although the positivities of the two were correlated with each other (P<0.025). The presence of SPC1q-CIC as well as anti-dsDNA antibodies showed a clear association with the general disease activity (P<0.001). The amount of SPC1q-CIC was correlated with decreased serum C4 levels (P<0.001), antissDNA (P<0.001) and anti-dsDNA (P<0.005) antibodies, and the grades of proteinuria (P<0.05). On the other hand, SPKg-CIC revealed weak correlations only with the general disease activity and anti-DNA antibodies, and showed no significant correlation with the serum C3 and C4 or grades of proteinuria. These data suggest that compared to SPKgBA, SPC1gBA may represent a more useful diagnostic tool which indicates the general disease activity and reflects the development of nephritis.抄録全体を表示PDF形式でダウンロード (1138K) -
TADAHIRO NISHI, KAZUO NOSAKA, HIROSHI KAWASAKI1984 年 26 巻 3 号 p. 301-307
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーTo investigate the role of the complement system in experimental membranous nephropathy, passive Heymann nephritis (PHN) was induced in female Sprague-Dawley rats by i. p. injection of rabbit anti-rat Fx1A serum. Rat C3 deposition along the glomerular capillary wall was present from 1 day through 2 weeks after the induction of PHN and then disappeared. In vitro complement activation by frozen sections of PHN kidneys was observed at 1 hour through 2 weeks after the induction of PHN. Thus, both in vivo and in vitro, complement activation by localized immune complex seems to occur predominantly at the heterologous phase of PHN. Two groups of rats were administered daily with cobra venom factor (CVF) or K-76 monocarboxylic acid (K-76), a C5 antagonist, for 7 days and the proteinuria was compared with a saline treated control group. CVF showed complete and K-76 showed partial inhibition of proteinuria at days 4 and 5. Similar CVF or K-76 treatment of PHN rats at 3 weeks after induction failed to reduce the proteinuria. No obvious difference in immune deposits was observed by immunofluorescence in any of these groups. In contrast to the model of nephrotoxic nephritis, no direct cellular action appeared to be associated with this complement dependent mechanism, since neither neutrophils nor monocytes were observed at any stage of PHN. It is suggested that late complements components C5-C9 or membrane attack complex may play a significant role in mediating proteinuria at the heterologous phase of PHN, while another complement independent mechanism is responsible for proteinuria at the autologous phase.抄録全体を表示PDF形式でダウンロード (3866K) -
TADAICHI KITAMURA, MASAYA OSHI, TAKASHI UMEDA, AKIRA UENO, TADAO NIIJI ...1984 年 26 巻 3 号 p. 309-317
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーA left adrenal pheochromocytoma in a 58-year-old man appeared to be successfully extirpated with simultaneous removal of the left kidney after an 8-hour operation, although, at the end of the operation, there was discoloration of some of the intrabdominal organs possibly due to intraoperative shock. Renal and hepatic failure associated with disseminated intravascular coagulation (DIC) became evident on the second postoperative day. The patient did not recover from that state and died 6 days after the operation. This case is considered to be one of intraoperative shocks followed by DIC in pheochromocytoma.抄録全体を表示PDF形式でダウンロード (6763K) -
KAZUTAKA MATSUSHITA, SHINZABURO HATTORI, SHINNIYO KARASHIMA, MASAKI YO ...1984 年 26 巻 3 号 p. 319-322
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーBetween July 1, 1980, and May 31, 1983, 33 children underwent surgical open renal biopsy. The musclemsplitting method was performed using the following procedures : anterior extraperitoneal approach (10 cases), flank approach (10 cases), and posterior approach (7 cases). The clinical results in the children undergoing open renal biopsy with these approaches are described, and the advantages and limitations of the different approaches are discussed.抄録全体を表示PDF形式でダウンロード (518K) -
HIDEAKI YAMABE, KUNIHIKO KIKUCHI, NOBUKI SUGAWARA, KAZUHIRO OZAWA, HIR ...1984 年 26 巻 3 号 p. 323-331
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーA 29-year-old woman with nephrotic syndrome and thrombocytopenia died of pulmonary thromboembolism. Autopsy revealed the presence of pulmonary emboli, verrucae of the right atrium, onion skin lesion of the spleen, and wire loop appearance of the renal glomeruli. The case described here represents a rare form of systemic lupus erythematosus complicated with pulmonary thromboembolism originating from verrucae of Libman-Sacks endocarditis.抄録全体を表示PDF形式でダウンロード (13591K) -
SEIHO NAGAFUCHI, HIROSHI YAMAOAMI1984 年 26 巻 3 号 p. 333-335
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーPDF形式でダウンロード (2210K) -
HIROSHI MIURA, NOBORU TAZOE, MICHIAKI HARA, KUNIHARU KUWAHARA, JIROH I ...1984 年 26 巻 3 号 p. 337-342
発行日: 1984年
公開日: 2010/07/05
ジャーナル フリーIn order to assess perirenal hematoma formation after percutaneous renal biopsy (PRB), ultrasonographic examinations were performed in 52 adult patients. Hematoma was found in 14 patients, representing an incidence of 26.9%. We found a correlation between the presence of hematoma and the clinical manifestations such as tenderness of the biopsy-sided hypochondrium, % decrease in hematocrit and increase of hematuria after PRB. Patients with these signs and symptoms after PRB should be carefully checked for their vital signs and be subjected to ultrasonography for assessing the possibility of perirenal bleeding.抄録全体を表示PDF形式でダウンロード (4068K)
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