巻号一覧
33 巻, 9 号
選択された号の論文の13件中1～13を表示しています
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YOSHIHIKO UEDA, YUKO ONO, ATSUSHI SAGIYA, FUMIO ISHITOBI, TOSHIRO TAKI ...1991 年 33 巻 9 号 p. 825-829
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーWe investigated the changes in anionic sites of the mesangial matrix related to aging in rats, employing polyethyleneimine (PEI) as a cationic probe. We compared the numbers of anionic sites detected by the immersion method and by the intravenous administration of PEI. Analysis of the mean numbers of PEI particles per 0.1 μm2 in the mesangial matrix revealed a significant decrease related to aging. Our results suggested that there was no significant difference in efficacy between the immersion and intravenous methods. Loss of negative charge of the mesangial matrix is believed to promote mesangial dysfunction and the entrapment of macromolecular substances, and so to play an important role in the onset of glomerular sclerosis.抄録全体を表示PDF形式でダウンロード (2801K) -
KAZUHIKO FUNABIKI, YASUHIKO TOMINO, HIKARU KOIDE1991 年 33 巻 9 号 p. 831-837
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーImmunohistochemical and light microscopic examinations were carried out to assess the correlation between the progression of glomerular lesions and changes in the intensity of glomerular extracellular components such as type IV and I collagens, laminin and fibronectin, and of IgA deposits in repeated renal biopsies of patients with IgA nephropathy. By light microscopy, the percentage of glomeruli showing glomerular mesangial expansion or sclerosis was found to be significantly higher in the second renal biopsy. Type IV collagen, laminin and fibronectin were also marked in the expanded glomerular mesangium in the second biopsy. Although these components were not observed in the global sclerotic glomeruli, type I collagen was detected in such areas of patients with IgA nephropathy. Patients who revealed high percentages of glomerular sclerosis associated with marked type IV collagen, laminin, fibronectin and/or type I collagen, had high levels of proteinuria and progressive deterioration of renal function. It is concluded that hyperproduction of the above extracellular components mainly in the glomerular mesangium is closely linked to the progression of glomerular lesions in patients with IgA nephropathy.抄録全体を表示PDF形式でダウンロード (4832K) -
KUMIKO HORA1991 年 33 巻 9 号 p. 839-848
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーThe ultrastructural features of isolated normal rat glomeruli were investigated using a new splitting technique and the quick-freezing and deep-etching (QF-DE) method. Examinations were also made of in vivo normal rat glomeruli by the QF-DE method to visualize the glomeruli under near natural conditions. Freeze-fractured capillary loops were observed from the capillary lumen or the urinary space. Foot processes were found to be freeze-fractured horizontally, obliquely or vertically to the glomerular basement membrane (GBM), and a glomerular slit diaphragm, which consisted of sheet-like, ladder-like and zipper-like substructures, was clearly identified. The GBM was classified into three zones, which might correspond to those seen in ultrathin sections, including the lamina densa and laminae rarae externa and interna. The lamina densa was composed of a meshwork filled with fine particles, which might represent products of insoluble proteins. In the laminae rarae, filamentous structures consisting of irregular networks could be observed connecting glomerular endothelial or epithelial cells with the lamina densa. Furthermore, the above findings were obtained from investigations at various consecutive levels of freeze-fractured capillary loops from various angles. The three-dimensional ultrastructure of the glomeruli could be demonstrated at high resolution by the QF-DE method.抄録全体を表示PDF形式でダウンロード (13188K) -
MASAE TANAKA, SADAHARU KATOH, NOBUHIRO SUGINO1991 年 33 巻 9 号 p. 849-855
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーThe anionic component of sodium salt has been reported to contribute to hypertension in some animal models and hypertensive patients. In the present study, the anionic effects on exacerbation of hypertension in spontaneously hypertensive rat (SHR) were investigated by chronic loading tests with two sources of sodium, viz, sodium chloride (NaCI; 0.9% solution) and sodium bicarbonate (NaHC03; 1.28% solution), using SHRs with normal renal function (NRF) and with chronic renal failure (CRF; produced by cryosurgery). In addition, extracellular fluid volume (ECFV: inulin space) was measured in SHRs with NRF and CRF. In the NRF groups, systolic blood pressure (SBP) reached 230 mmHg at Week 13, and there was no significant difference in SBP between the NaCI and NaHC03 groups. In the CRF groups, SBP of the NaCI group was significantly higher (p<0.01) than that of the NaHC03 group (280 mmHg vs. 230 mmHg at Week 15). ECFV was also greater in the NaCI group than in the NaHC03 group (ECFV: NaCI vs. NaHC03, 15.9±1.7 vs. 14.0±0.9 at Week 13; and 16.2±1.1 vs. 14.2±1.2 at Week 15, respectively). These results indicate that chloride ion plays an important role in the pathogenesis of hypertension in SHR with CRF. Expansion of ECFV is considered to be one of the mechanisms whereby the hypertension is exacerbated.抄録全体を表示PDF形式でダウンロード (908K) -
YOHEI TOFUKU, ICHIRO KONI, RYOYU TAKEDA, TAKASHI SATO1991 年 33 巻 9 号 p. 857-862
発行日: 1991年
公開日: 2011/03/01
ジャーナル フリーWe investigated the urinary acid excretion and urine anion gap (AG) (Na++K+-CI-) during NH4C1-induced metabolic acidosis in 38 normal subjects and 53 patients with chronic renal diseases in order to clarify the significance of the urine AG as a useful marker of the ammonium (NH4+) excretion even in a state of chronic renal insufficiency. The urine pH became higher, and the urinary excretions of titratable acid (TA) and NH4+ decreased significantly, in parallel with a reduction of the creatinine clearance (Ccr). The urinary electrolyte excretion, especially the chloride excretion, also decreased significantly as Ccr fell. As a result, the urine AG increased from negative to positive values, in proportion to the decrease in Ccr with statistical significance. The urine AG showed the most significant correlation with the urine NH4+ excretion (r=-0.707, p<0.001). We conclude that the urine AG provides a significant marker of the urine NH4+ excretion even in a state of moderate to severe renal insufficiency.抄録全体を表示PDF形式でダウンロード (746K) -
SHIGEKI HATAMA, MASAHIKO NAKAMOTO, ATSURO IMAMURA, HIDETOSHI KANAI, TE ...1991 年 33 巻 9 号 p. 863-866
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーWe report here a case of penile gangrene in a patient with diabetic nephropathy treated by continuous ambulatory peritoneal dialysis (CAPD). The patient demonstrated severe systemic arteriosclerosis. The main cause of the gangrene was considered to be circulatory insufficiency induced by severe arteriosclerosis . Several predisposing factors including chronic renal failure, long-term diabetes mellitus and CAPD-related metabolic changes such as abnormalities of lipid metabolism also appeared to have contributed to the arteriosclerotic changes. The prognosis in cases of this type is thought to be extremely poor.抄録全体を表示PDF形式でダウンロード (4078K) -
TAKERU IWATA, SHINJIRO MUNETA, YUTAKA KITAMI, TAKAFUMI OKURA, YASUKO I ...1991 年 33 巻 9 号 p. 867-871
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーRenal denervation has been shown to delay the onset of hypertension in spontaneously hypertensive rats and DOCA-salt sensitive rats. We investigated the contribution of the renal nerves to the development of hypertension in Dahl-Iwai salt-sensitive (DS) rats. Bilateral renal denervation or sham-operation was carried out in DS rats, and animals were then kept on a high salt diet (study I) or on a normal salt diet (study II). DS rats became severely hypertensive (207±8 mmHg) after 4 weeks on a high salt diet. They became mildly hypertensive (156±3 mmHg) after 4 weeks on a normal salt diet. In both studies, renal denervation exerted no effect on the development of hypertension in the DS rats. The urinary sodium excretion, urinary volume, heart rate and body weight were unaltered by renal denervation. These results indicate that the renal nerves do not make a major contribution to the development of hypertension in DS rats.抄録全体を表示PDF形式でダウンロード (692K) -
HIROSHI KAWAMURA, HIROAKI TOMORI, YUZI NARUSE, MASAHIRO MAKI, KAZUTOSH ...1991 年 33 巻 9 号 p. 873-878
発行日: 1991年
公開日: 2011/03/01
ジャーナル フリーA high sodium diet increased the plasma norepinephrine (PNE) only in resting spontaneously hypertensive rats (SHR). SHR on either a high or low sodium diet showed a greater increase in arterial pressure (AP) than Wistar-Kyoto rats (WKY) with foot shock (FS). However, neither a high nor low sodium diet enhanced the increment of AP in both SHR and WKY with FS. Only a low sodium diet enhanced the increment of PNE and plasma epinephrine in SHR with FS. Extreme restriction of sodium intake might thus enhance the response of sympathetic activation with stressful stimuli.抄録全体を表示PDF形式でダウンロード (768K) -
Sympathetic and renin-angiotensin system in conscious rabbits with two-kidney, one clip hypertensionKOSHIRO YOSHIDA, MASANOBU TAKATA, HITOSHI UENO, FUMIHIRO TOMODA, KOTAR ...1991 年 33 巻 9 号 p. 879-884
発行日: 1991年
公開日: 2011/03/01
ジャーナル フリーWe attempted to clarify the contribution of the altered neural mechanism associated with increased angiotensin II to two-kidney, one clip (2K IC) hypertension on the 3rd and 35th days after renal artery stenosis. 2K1C hypertension was produced in 20 rabbits, and a sham operation was performed in 11 rabbits. Sarl, 11e8 angiotensin II (AIIA) infusion tests and baroreflex sensitivity determinations by bolus injection of phenylephrine were performed on the 3rd and 35th days after renal artery stenosis. The blood pressure was 12 mmHg higher in the hypertensive rabbits than in the sham operated rabbits on the 3rd day after clipping. The blood pressure returned to the control level during the infusion of AIIA. On the 35th day after clipping, AIIA-sensitive or AIIA-resistant hypertension developed. The blood pressure was higher in the AIIA-sensitive rabbits than in the AIIA-resistant rabbits (131.±5 vs 116.±4 mmHg, p <0.05). The baroreflex sensitivity was lower in the AIIA-sensitive rabbits than in the AIIA-resistant rabbits (1.8.±0.3 vs 2.8.±0.3 msec/mmHg, p <0.05). There was no difference in plasma norepinephrine between the two groups on either the 3rd or 35th day. Thus, impaired baroreflex sensitivity was found in the accelerated hypertension seen in the chronic phase of 2K1C hypertension. Neural mechanisms mediated by the peripheral sympathetic nervous system did not appear to contribute to the development of 2K1C hypertension.抄録全体を表示PDF形式でダウンロード (910K) -
YASUO KUDOH, TOSHIAKI KIJIMA, OSAMU IIMURA1991 年 33 巻 9 号 p. 885-888
発行日: 1991年
公開日: 2011/03/01
ジャーナル フリーAcute thrombocytopenia due to intravenous infusion of radiographic contrast media is extremely rare. We report the first such case in Japan. A 52-year-old male was admitted to hospital because of right ureteral stone. Two hours after drip infusion pyelography, the patient experienced chills and fever. It was shown that his platelet count had decreased abruptly from 233, 000 to 8000/mm3. Platelet associated immunoglobulin was not detected. An in vitro test for platelet aggregation by contrast media was negative. Following infusion of hydrocortisone, the platelet count recovered to a normal level within several days.抄録全体を表示PDF形式でダウンロード (463K) -
TATSUO UCHIDA1991 年 33 巻 9 号 p. 889-897
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーThe process of development of acquired cysts and neoplasms in the kidneys of patients receiving hemodialysis was investigated. An ultrasonographic study of 329 hemodialysis patients revealed that the size of the kidney decreased in the first 3 years of dialysis, then increased up to 8 years, and thereafter decreased again. Morphometric and histopathological studies were conducted on 31 kidneys removed from 17 patients. The total number of cysts and total volume of cysts increased over the period of 3 to 8 years, and renal size was positively correlated with total cyst volume during this period. The incidences of atypical hyperplastic cysts and microadenomas increased with prolongation of the dialysis period. Three cases of renal cell carcinoma were observed in the present series, of which two exhibited extensive cystic transformation with numerous neoplastic foci. These findings indicate a close relationship between the extent of acquired cysts, dialysis duration and risk of renal neoplasms.抄録全体を表示PDF形式でダウンロード (8443K) -
YUJI NAGURA, NOBUYUKI YOSHIZAWA, SUSUMU TAKAHASHI1991 年 33 巻 9 号 p. 899-905
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーVarious effects on renal function and factors which tend to cause aggravation in pregnancy and delivery in patients with renal diseases have been described previously. In the present study, the authors undertook personal and telephone inquiries to patients with renal insufficiency due to aggravated renal dysfunction occurring during the course of pregnancy and delivery, and to those showing a favorable course despite renal dysfunction before pregnancy. Sixty-four patients with IgA nephritis were investigated, covering 101 cases of pregnancy in them. The management of the pregnant women and their social and home (family/domestic) environments were taken into consideration, since these are important for giving guidance in their daily life to overcome various factors which influence the course of spontaneous pregnancy and delivery. The following findings were obtained. (1) In patients with hypertension, toxemia of pregnancy, abnormal delivery and abortion were frequently complicated. (2) Patients under greater mental and physical stresses during the course of pregnancy and after delivery showed a poorer prognosis for both mother and fetus. (3) Generally speaking, guidance should be given not to be overconfident or overdefensive in pregnancy. (4) Working women revealed a prognosis which was poorer than that of housewives.抄録全体を表示PDF形式でダウンロード (717K) -
MITSURU YANAI, NGUYEN-KHOA MAN, BERNARD LEBKIRI, LORELEY BOUDIER, SUSU ...1991 年 33 巻 9 号 p. 907-913
発行日: 1991年
公開日: 2010/07/05
ジャーナル フリーIn an attempt to evaluate the adequacy of regular dialysis therapy, calculations of Kt/V-urea and protein catabolic rate (pcr) from the data of routine laboratory examinations by means of urea kinetic modeling were performed in 59 regular dialysis patients (28 males and 31 females; mean age, 59±2 years old; mean dialysis duration, 83±10 months). The mean values of Kt/V-urea and pcr were 1.10±0.04 and 0.98±0.03 g/kgBW . day, respectively. The number of patients who were within the optimal range (0.9-1.4 for Kt/V urea and 0.9-1.5 for pcr) was 37 (62.7%) for Kt/V-urea and 38 (64.4%) for pcr. Furthermore, we inferred that, based on an appropriate dietary protein intake, removal of urea by intermittent dialysis should be adjusted to maintain the patient in equilibrium for a defined pre-dialysis plasma urea concentration. From the data obtained, we concluded that: (1) it is possible to apply urea kinetic modeling on the basis of routine laboratory examinations, (2) it is important to maintain the pre-dialysis plasma urea concentration at more than a certain level, and (3) it is also important to control the post-dialysis plasma urea concentration at a low level.抄録全体を表示PDF形式でダウンロード (2293K)
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