巻号一覧
36 巻, 1 号
選択された号の論文の13件中1～13を表示しています
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SHINYA TSUCHIDA, MASAHIRO HIRAOKA, HIROKAZU TSUKAHARA, AKIRA I. NEGAMI ...1994 年 36 巻 1 号 p. 1-8
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーWe characterized the morphological expression of glomerular endothelial cells (GEC) cultured on a basement membrane matrix, Matrigel. GEC cultured on this matrix formed abundant networks of branching and anastomosing cords of cells, and formed capillary-like structures with a lumen and inter digitating junctional processes. In contrast, GEC cultured on fibronectin-coated dishes had elongated spindle shapes without any interdigitating junctional processes. These findings suggest that the culture system with Matrigel is useful for inducing and maintaining characteristics close to in vivo GEC.抄録全体を表示PDF形式でダウンロード (3017K) -
KOSAKU NITTA, KEIKO UCHIDA, AKIRA KAWASHIMA, TAKAAKI TSUTSUI, HIROYUKI ...1994 年 36 巻 1 号 p. 9-12
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーThe localization of GTP-binding proteins (G-proteins) in human glomeruli was examined using immunohistochemistry and immunoblotting. Immunohistochemical staining for G-protein subunits demonstrated the existence of Gsα, Giα and Goα proteins in the glomeruli. Moreover, immunoblots further revealed Gsα (52 kD), Giα 1/2 (40-41 kD), Giα 3 (40kD) and Goα (39 kD) in the glomerular membranes. The predominant subspecies of GS was a 52-kD protein, and Goα was detectable in the smallest amounts of the G-protein subunits. However, immunoblots failed to demonstrate detectable amounts of G-proteins in cytosolic extracts. This is the first report that characterizes G-protein subunits in human glomeruli. Further study is required to determine the roles of G-proteins in signal transductions in human glomeruli.抄録全体を表示PDF形式でダウンロード (1412K) -
TAKAKO YOKOZAWA, MASAYUKI IWANO, KAZUHARU DOHI, MASAO HATTORI, HIKOKIC ...1994 年 36 巻 1 号 p. 13-18
発行日: 1994年
公開日: 2010/07/05
ジャーナル フリーTo evaluate the pharmacological action of ginseng, its effects on the proliferative activity of mesangial cells, which are thought to play an important role in the regulation of renal function, were determined in terms of [3H]thymidine uptake. When the extract was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells, and similar proliferation-inhibitory activity was found in the total saponin and ginsenoside-Rd fractions, consistent with the renal effects observed in our previous in vivo studies. The inhibition of mesangial cell proliferation by the extract can thus be explained by the action of ginsenoside-Rd.抄録全体を表示PDF形式でダウンロード (825K) -
AKIHIKO SAITO, MINORU SAKATSUME, HAJIME YAMAZAKI, MASAAKI ARAKAWA1994 年 36 巻 1 号 p. 19-24
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーType IV collagen is a complex molecule composed of three α chains that can be of types α1(IV) to α 5(IV). Each α chain contains an amino-terminal collagenous domain and a carboxyl-terminal noncol lagenous (NC) domain consisting of 229 amino acids, which is involved in intermolecular cross-linking to construct the basement membrane network. Specific localization of α5(IV) collagen in glomerular basement membranes (GBM) in the kidney indicates its crucial role for that construction. In human kidney cortex and skin RNA, we found an alternative splicing transcript which skips exon 50 of the α 5(IV) collagen gene using reverse transcription-polymerase chain reaction and direct sequencing of the PCR products. This alternative splicing introduces a stop codon at the first colon of exon 51, resulting in an mRNA encoding a protein lacking the 84 NC domain carboxylterminal amino acid residues encoded by exons 50 and 51. Recently, gene mutations affecting the α5(IV)collagen NC domain have been reported in patients with X-linked Alport syndrome who display GBM destruction and progressiverenal failure, which are usually milder in female patients. Therefore, the alternative splicing, if its truncated products are dominantly expressed in glomeruli, may cause GBM impairment and renal failure progression.抄録全体を表示PDF形式でダウンロード (1820K) -
HIDEKAZU SHIGEMATSU, YUTAKA KOBAYASHI, SUMIO TATENO, YOSHIYUKI HIKI, S ...1994 年 36 巻 1 号 p. 25-32
発行日: 1994年
公開日: 2010/07/05
ジャーナル フリーThe occurrence of significant tubulointerstitial nephritis (TIN) was observed in 6 (18.3%) of 32 patients with IgA nephritis registered in 1991. T lymphocytes and macrophages in the interstitium were seen to invade the tubulus through injured tubular basement membrane (TBM), then were seen in the intercellular spaces of tubular cells which showed degeneration, single cell necrosis or detachment. Thus some tubular components were seen destroyed and had disappeared resulting in interstitial fibrosis, and others showed a regeneration process forming a renewed TBM on the innerside of the original TBM. However the recurrence of cellular inflammation was again observed in these regenerated tubuli. Thus the progression of nephron loss by TIN was seen to be independent of the glomerular changes and TIN is considered to be one of the important factors in predicting the prognosis of IgA nephritis.抄録全体を表示PDF形式でダウンロード (5522K) -
EIJI HIRATA, MASAYUKI IWANO, TOSHIHIDE HIRAYAMA, YASUHIRO HORII, YOSHI ...1994 年 36 巻 1 号 p. 33-37
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーTo determine whether the urinary level of interleukin 6 (IL-6) measured by enzyme-linked immunosorbent assay (ELISA) can be used as a marker of mesangial proliferation, we studied urinary levels of IL-6 in 124 patients with primary and secondary glomerulonephritis, using ELISA. Although urinary levels of IL-6 were correlated with the degree of mesangial proliferation, there was no correlation between urinary levels of IL-6 and urinary protein excretion or renal function. Urinary levels of low-molecular-weight proteins, which are parameters of tubular dysfunction, were not correlated with the urinary excretion of IL-6. These results suggest that the urinary level of IL-6 may be a useful marker for mesangial proliferation.抄録全体を表示PDF形式でダウンロード (772K) -
KATSUMI MURAKAMI, KAZUO YOSHIOKA, NORIHISA AKANO, TSUKASA TAKEMURA, MI ...1994 年 36 巻 1 号 p. 38-43
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーWe retrospectively evaluated renal outcome in a total of 38 children and adolescents with IgA nephropathy who were selected for 6-month therapy for clinical (proteinuria>1g/m2/24 hour) and pathologic (mesangial proliferation, crescent formation, and tubulo-interstitial changes) features suggestive of progressive renal failure. Seventeen patients (group A) were treated with a combination of prednisolone, cyclophosphamide and dipyridamole, and the remaining patients (21; group B) were treated with the same drugs plus warfarin. All the patients were followed-up for more than 2 years (range 2-10 years, mean 4.8). In both groups, the mean urinary protein excretion value was significantly reduced after the therapy, compared with that at entry into the therapy . The significant reduction continued for up to 6 years in group A and up to 5 years in group B . Creatinine clearance was stable until 5-6 years after the trial in both groups, but 4 patients progressed to end-stage renal failure after that period. Post-therapy biopsy was performed in 14 patients, and was compared with the pre-therapy biopsy. The activity score had improved in both groups, but the chronicity score did not. These results indicate that there was a temporary effect and limited benefit with this treatment of combined drugs for children and adolescents with IgA nephropathy . The additive effect of warfarin was not substantiated.抄録全体を表示PDF形式でダウンロード (728K) -
YOSHIYUKI OZONO, TAKASHI HARADA, KOICHI YAMAGUCHI, KOICHI TAURA, KOHEI ...1994 年 36 巻 1 号 p. 44-50
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーClinical and pathological findings and the effects of therapy were investigated in 90 cases of nephrotic syndrome (NS) in elderly patients aged over 60 years. Membranous nephropathy was the most frequent type of primary NS. Amyloidosis and malignancy were common causes of secondary NS. Damage to the interstitium in the kidney, such as focal mononuclear cell infiltration, fibrosis and thickening of the small arterial wall in membranous cases, was often observed. Stage I and II based on electron-microscopy, were mainly observed in the patients, with membranous nephropathy. Prednisolone and immunosuppressive agent were most effective in these patients with membranous nephropathy. Prednisolone alone was the most effective on minimal change NS in the elderly. In the course of therapy, side effects such as pneumonia, sepsis due to fungus infections, such as aspergillus and candida, and infection, such as cytomegalovirus and herpes zoster, were more frequently observed, especially in the cases of MPGN, DPGN with moderate to severe mesangial proliferation, with a decline in renal function (Ccr<50 L/day) and secondary NS. In secondary NS, the prognosis of amyloidosis was very poor and the findings pointed to a relationship between malignancy and nephrotic syndrome.抄録全体を表示PDF形式でダウンロード (946K) -
YUTAKA IMAI, YOSHIHIRO FUJIKURA, NAOYOSHI MINAMI, MASANORI MUNAKATA, J ...1994 年 36 巻 1 号 p. 51-56
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーWe investigated whether the treatment of anemic hemodialysis patients with a low dose of recom binant human erythropoietin (rHEpo) for a short period would increase the blood pressure (BP). Home BP measurements were used to detect minute increases in BP. Fifty-one anemic patients on maintenance hemodialysis with a hematocrit of 25% or less received rHEpo at the dose of 4500IU/week by the intravenous route for 8 weeks. Overall, rHEpo did not increase the BE whether measured at home or in the clinic (casual BP). Hemoglobin concentration increased significantly from 7.1±0.7 to 8.8±0.7 g/dl. Patients were classified into two groups according to the change in mean (M) home BP induced by rHEpo: a pressor group (ΔMBP<5 mmHg, n=17) and a non-pressor group (ΔMBP≥5 mmHg, n= 34). The hemoglobin concentration rose significantly in both groups, but there was no change in casual BP. Home blood pressure measurements showed a gradual and continuous rise in BP in the pressor group, but not in the non-pressor group. Patients administered antihypertensive medications before rHEpo treatment accounted for 88% of the former and 50% of the latter groups. Two patients with malignant nephrosclerosis were included in the pressor group. The findings indicate that rHEpo, even given at a low dose for a short period, elevates the BP, as determined by home BP measurement, but not by casual measurements obtained in the clinic.抄録全体を表示PDF形式でダウンロード (799K) -
YUTAKA TAKAHASHI, YASUHIKO TOMINO, MASAYASU MIZOKUCHI, HIROYUKI OHMURO ...1994 年 36 巻 1 号 p. 57-62
発行日: 1994年
公開日: 2010/07/05
ジャーナル フリーA 59-year-old woman has had persistent microscopic hematuria for 10 years. A few days after the onset of upper respiratory tract infection, edema and severe proteinuria appeared. In renal biopsy, an electron micrograph revealed electron dense deposits in the subepithelial regions with diffuse thinning of the glomerular basement membrane. These glomerular findings were compatible with thin basement membrane syndrome associated with membranous nephropathy. On the basis of our review of the literature, the association of these two diseases seems to be very rare.抄録全体を表示PDF形式でダウンロード (3290K) -
KAZUNAGA TAKAMATSU, YUKIO IKEDA, YU NAKAUCHI, MASUI KAWADA, KOZO HASHI ...1994 年 36 巻 1 号 p. 63-68
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーWe report here the autopsy findings in a 51-year-old man who had been admitted with Henoch Schonlein purpura (HSP) accompanied by rapidly progressive glomerulonephritis and massive intra peritoneal hemorrhage, leading to death. While the intraperitoneal hemorrhage was the primary cause of death, the patient may have suffered widespread intraperitoneal vasculitis due to HSP, or hemorrhagic pancreatitis due to the concurrent administration of a steroid and furosemide. We emphasize the acute hemorrhagic pancreatitis is a possible complication in patients with generalized vasculitis, including HSP and collagen disease, during the concurrent administration of steroids and other agents.抄録全体を表示PDF形式でダウンロード (5918K) -
TATSUMI MORIYA, TOSHIO SHINODA, YUTAKA KANNOU, KOUJI NAKAJIMA, TEIJI T ...1994 年 36 巻 1 号 p. 69-75
発行日: 1994年
公開日: 2011/07/04
ジャーナル フリーWe report a 49-year-old Japanese male with nephrotic sydrome associated with Kimura's disease. Renal biopsy revealed diffuse podocytic detachment from the glomerular basement membrane (GBM). He had an episode of nephrotic syndrome when complete remission was induced with steroid therapy six years prior to the present admission. However, complete remission of the nephrotic syndrome was not achieved by the steroid on this admission and massive proteinuria (5g/day) persisted. We suggest that steroid-resistant proteinuria is closely related to podocytic detachment from the GBM and that the production of extracellular matrix by epithelial cells may participate in segmental sclerotic lesions in the patient.抄録全体を表示PDF形式でダウンロード (12578K) -
HARUHIKO VEDA, TADASHI KANOH, HIROHIKO OHARA, SUSUMU ITOH, YUJI MATSUO ...1994 年 36 巻 1 号 p. 76-79
発行日: 1994年
公開日: 2011/03/01
ジャーナル フリーWe report a case of selective IgA deficiency in a girl who received a successful renal transplant from a donor with normal serum IgA level. Although the recipient serum was negative for anti-IgA antibody, the donor kidney was washed with a sufficient volume of perfusate and the amount of cortico steroid given to the patient immediately after the revascularization was increased to twice the normal dose. Serum complement level transiently decreased, but recovered during the first week after surgery. Although the patient suffered from acute pyelonephritis of the graft during the fourth month, there has been no evidence of infection thereafter.抄録全体を表示PDF形式でダウンロード (644K)
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