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Volume 39, Issue 8
Displaying 1-4 of 4 articles from this issue
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Kosaku NITTA, Keiko UCHIDA, Kazuho HONDA, Keiko MATSUGAMI, Yoko ETO, K ...1997 Volume 39 Issue 8 Pages 777-782
Published: 1997
Released on J-STAGE: March 01, 2011
JOURNAL FREE ACCESSTo elucidate the effects of recombinant human erythropoietin (rHuEpo) on the interactions between glomerular endothelial cells (GENs) and mesangial cells (GMCs), we investigated whether or not cultured bovine GENs alter endothelin (ET)-1 secretion from bovine MCs and MC proliferate under basal or rHuEpo-stimulated conditions. Incubation for 24 hours with synthetic ET-1 stimulated MC in a dose-dependent manner. In addition, 100 pg/ml of ET-l significantly stimulated MC proliferation after more than 12 hours incubation. Moreover, rHuEpo stimulated ET-1 secretion from GENs in a dosedependent manner and showed less stimulation of ET-l secretion from GMCs than GENs . DNA synthesis in both GENs and GMCs was significantly stimulated with more than 5U/ml of rHuEpo . ET-1 secretion from GENs co-cultured with GMCs was higher than that from cultured GENs only . Conditioned medium, obtained from co-culture of GENs and GMCs, stimulated the proliferation of GMCs that were significantly inhibited with 10-6 M10-5 M BQ-123, , a ETA receptor antagonist. These results suggest that rHuEpo directly stimulates the proliferation of GENs and GMCs, and this stimulatory effect is in part due to ET-1 secreted from these cells, especially GENs.View full abstractDownload PDF (909K) -
Kenji KASAI, Hideyuki KOBAYASHI, Hiroyuki TERAWAKI, Keita HIRANO, Yasu ...1997 Volume 39 Issue 8 Pages 783-789
Published: 1997
Released on J-STAGE: March 01, 2011
JOURNAL FREE ACCESSIt is generally accepted that residual renal function remains well-preserved longer with CAPD than with hemodialysis. However, consideration and impact of the contributory effects of residual renal function on the adequacy of renal replacement therapy has not been well defined. In this report, creatinine clearance (Ccr), Kt/V, normalized protein catabolic rate (nPCR) and urinary excretion of uremic solutes were studied in 26 stable CAPD patients with a four-bag exchange. Weekly Ccr, weekly Kt/V and nPCR were 62.3±20.2 l/week/1.73 m2, 1.77±0.35, and 0.90±0.13 g/kg/day, respectively. These parameters correlated significantly with the daily urine volume. The weekly Ccr and Kt/V of anuric patients seemed to be inadequate. Urinary excretion of urea nitrogen, Cr, Na, Cl, Pi and β2-microglobulin (β2 MG) were dependent upon the daily urine volume. Significant phosphorus and β2-MG excretion seemed to have an effect on the prevention of bone and joint complications, because serum iPTH and β2-MG levels increased after the patients fell into an anuric state. It was suggested from this study that CAPD should be started before the patient loses residual renal function because four bag exchange as the standard CAPD prescription might not be adequate once the patient loses urine excretion.View full abstractDownload PDF (1015K) -
Yoshikazu SATO, Ashio YOSHIMURA, Hideki SAKAI, Saneo YOGI, Yoshio KAI, ...1997 Volume 39 Issue 8 Pages 790-793
Published: 1997
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSWe have encountered a 23-year-old pregnant woman with macrohematuria, which occurred from the 8th or 9th week of gestation. Blood pressure and renal function were normal during the total course of pregnancy. Macrohematuria did not disappear after childbirth. Cystoscopy was conducted and the excretion of hematuria from the left ureter was confirmed. Therefore, a left renal venogram was performed although abdominal ultrasonography and CT scanning showed no abnormality. There were two branches of the left renal vein (LRV), such as the anteior and posterior branch. The pressure gradient was 4.4 cm H2O between the anterior branch of LRV and the inferior vena cava (IVC) . However, a significant pressure gradient (6.6 cm H2O) was demonstrated between the posterior branch of the LRV and IVC. From these findings we diagnosed this patient as venous hypertension in the posterior branch of the left renal vein (=posterior Nutcracker syndrome, PNS). Enlargement of the uterus in pregnancy might not be important in the occurrence of PNS because macrohematuria was observed from the 8th or 9th week of gestation. Functional hemodynamic change in pregnancy might cause a widening of the diameter or a shift of the aorta, that might result in compression of the posterior branch of the left renal vein. Persistence of macrohematuria after childbirth might have been due to irreversible hemodynamic alteration by the development of colateral circulation. To the best of our knowledge, this is the first case of PNS occurring in pregnancy.View full abstractDownload PDF (1206K) -
Atsuo TANAKA, Ritsuo NISHIDA, Kazutomo SAWAI, Tetsuya NAGAE, Satsuki S ...1997 Volume 39 Issue 8 Pages 794-797
Published: 1997
Released on J-STAGE: July 05, 2010
JOURNAL FREE ACCESSA 19-year-old female was referred to our hospital for azotemia and anemia. She had been taking a health food for atopic dermatitis for about three years. Urinalysis showed proteinuria, glycosuria and microscopic hematuria. Generalized aminoaciduria was observed. Moreover, severe anemia, azotemia, hypokalemia and hypophosphatemia were also observed. Renal biopsy specimen disclosed hypocellular interstitial fibrosis and degeneration of the proximal tubular epithelial cells. No remarkable changes were observed in the glomeruli. Aristolochic acid was detected in the health food. From these findings, she was diagnosed as having Chinese herbs nephropathy (CHN). Although consumption of the food intake was stopped, her renal function deteriorated rapidly. Previously, we reported that certain kinds of Chinese herbal drugs contain aristolochic acid and that the drugs should be prohibited if aristolochic acid is identified. However, we experienced a patient of CHN arising from traditional remedy, which was not proved to be safe. It should be awared that health foods may contain aristolochic acid.View full abstractDownload PDF (907K)
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