The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
Volume 83 , Issue 9
Showing 1-21 articles out of 21 articles from the selected issue
  • Makoto Miki
    1992 Volume 83 Issue 9 Pages 1389-1394
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
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  • Haruo Ito
    1992 Volume 83 Issue 9 Pages 1395-1399
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    It is unclear whether the oxalate in foods degrades or not in the intestinal tract. We isolated oxalic acid decarboxylase from anaerobic bacteria present in human feces which was grown in the culture medium containing oxalic acid as the sole carbon source. The enzyme was partially purified by 80% ammonium chloride precipitation, DEAE-cellulose chromatography and molecular sieve chromatography. The amino acid composition was found to be relatively rich in glycine and alanine, but to have low basic, hydrophobic and aromatic amino acid residues compared with average proteins.
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  • Takashi Fukushima
    1992 Volume 83 Issue 9 Pages 1400-1409
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Effects of extracorporeal shock waves on renal tissue, renal function, and blood pressure were studied by applying 500 shock waves to both kidneys in 72 female Wistar rats. Six groups, 12 rats in each, were sacrificed on days, 1, 7 and at months 1, 3, 6 and 12 after the procedure, when serum levels of BUN, creatinine, urine levels of β2-microglobulin (β2-MG), N-acetyl-β-D-glucosaminidase (NAG), 28-kDa carbindin-D and creatinine clearance (Ccr) were determined. Findings were then compared with those from the control group. In each group, both kidneys were weighed and histologically evaluated. In the treatment group, systolic blood pressure was measured at post-irradiation months 1, 3, 6, 9, and 12; plasma renin activity was studied 6 and 12 months after irradiation to make evaluation in comparison with the control group. In the treatment group, histologically, coagulative necrosis associated with bleeding around the renal tubules and tubular epithelial cell degeneration were marked on day 1, but the glomerulus was kept in relatively good shape. Inflammatory cellular infiltration and interstitial fibrosis were noted on day 7 and the addition of scar formation 1 month after irradiation. Interstitial fibrosis, inflammatory cellular infiltration, scar formation, and tubular epithelial degeneration remained significant even after 12 months. In the treatment group, kidneys weighed significantly more than in the control group from day 1 through month 3, with edema likely accounting for this. However, weight then significantly declined 12 months after irradiation, owing to suspected scarring atrophy. Levels of serum creatinine, urinary β2-MG, and urinary NAG were all significantly elevated on days 1 and 7, and levels of BUN and 28-kDa carbindin-D were significantly elevated on days 1, 7, and month 1. Level of Ccr was significantly decreased on day 1 and 7. No significant differences between the treatment group and the controls were noted in serum creatinine, Ccr, urinary β2-MG, and urinary NAG at month 1 and thereafter or in BUN and urinary 28-kDa carbindin-D at month 3 and thereafter. Measurement of urinary concentration of 28-kDa carbindin-D showing high levels specific to the distal tubule cells in the kidneys was considered to be a reliable index for determining the presence or absence of a disorder affecting distal tubules due to ESWL. Year-long observation did not reveal significant changes in systolic blood pressure or plasma renin activity.
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  • Masahiro Fukuba, Yukio Homma, Yoshio Aso
    1992 Volume 83 Issue 9 Pages 1410-1416
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    A single session of transurethral microwave thermotherapy using Prostatron (Technomed International, France) was performed in 20 patients with benign prostatic hyperplasia, and the clinical efficacy of this modality was evaluated by analysing the subjective and objective responses following the treatment. 1, 296MHz microwaves are delivered to the prostate by an antenna placed in a 20 Fr urethral balloon catheter equipped with a cooling system for preservation of the urethral mucosa. The treatment was performed in a single session for an hour on an outpatient basis. The clinical efficacy was evaluated by a total score of subjective symptoms and objective findings including residual urine and average flow rate, 8 weeks after the treatment. Reduction of subjective symptom score was observed in 26 cases (86.7%), and that of objective findings in 21 (70%). When 25% or more decrease of the total score was defined as good, the overall good result including subjective and objective responses was seen in 24 cases (80%). During the treatment and follow-up period, no severe adverse effect was detected.
    In conclusion, a single session of thermotherapy by Prostatron is a safe and useful modality as a non-surgical treatment performed on an outpatient basis for benign prostatic hyperplasia.
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  • Yoshitaka Kaneda, Akira Kai, Jisaburo Sakatoku
    1992 Volume 83 Issue 9 Pages 1417-1422
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    We treated 5 cases of severe hydronephrosis with balloon dilation. Those hydronephrosis were due to the ureteral stricture with small stone fragments after ESWL (Lithostar). In each case, in situ ESWL had been done on a long-lodged ureteric stone with severe hydronephrosis. And even after the disintegration of stone with ESWL, hydronephrosis remained due to ureteral stricture with small stone fragments. Balloon dilation was done through percutaneous nephrostomy tract in 4 cases and via retrograde transurethral route in 1 case. Balloon dilation catheter (7fr. 6mm diameter 4-10cm length, Bard Co.) was used. There was no need for stone extraction. After dilation, ureteric stents (8.2/7fr.) were kept in place for 4-8 weeks. Intravenous urogram was taken on 4-8 weeks after removing ureteric stents. In all of the 5 cases, improvement of hydronephrosis was remarkable.
    And there was no residual stone fragments in 4 cases. It is concluded that balloon dilation for ureteral stricture with stone fragments after ESWL is very useful. For the valid evaluation of balloon dilation, further experience and longer observation are requisite.
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  • Mikinobu Ohtani, Naoto Miyanaga, Ryousuke Noguchi, Akira Sasaki, Hidey ...
    1992 Volume 83 Issue 9 Pages 1423-1428
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The effect of intravesical instillation of dimethylsulfoxide (DMSO) on bladder carcinogenesis was examined in mice.
    Experiment 1: Fifty-five female C3H/He mice were administered 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in their drinking water for 8 weeks. In week 9 they were divided into two groups consisting of 25 mice each. Then, under nembutal anesthesia the first group was given weekly intravesical inatillations of 0.1ml DMSO (minimum 99.0%) for 10 weeks. The second group received no treatment except anesthesia. All mice were killed 30 weeks after the begining of the experiment and their urinary bladder resected for histological examination. The incidence of bladder carcinoma was 93.7% (15.16) and 27.7% (6/22) in groups 1 and 2, respectively. These incidences differed significantly between the two groups.
    Experiment 2: One hundred and twenty female C3H/He mice were divided into two groups. The first group was given 0.05% BBN in their drinking water for 5 weeks and then tap water. The second group was not given BBN. In week 6, the first group was divided again into three groups (1, 2 and 3) consisting of 28, 26, and 27 mice, respectively. The second group was divided into groups 4 and 5 consisting of 21 and 18 mice, respectively. Under nembutar aesthesia groups 1 and 4 received weekly intravesical instillation of 0.05ml DMSO (minimum 99.0%) from weeks 6 to 13, Group 2 received weekly intravesical instillation of 0.05ml distilled water from weeks 6 to 13. Groups 3 and 5 received no treatment except anesthesia. In week 14 and 30 animals were killed for histological examination. The incidence of bladder carcinoma was 6/25 (25%), 0/22 (0%), 0/25 (0%), 0/20 (0%) and 0/18 (0%) in groups 1, 2, 3, 4, and 5, respectively. This incidence in group 1 was significantly different from that in groups 2, 3, 4, and 5 (p<0.05).
    These results suggest that intrevesical instillation of DMSO promotes the development of urinary bladder carcinogenesis in mice.
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  • Yoshinori Hara
    1992 Volume 83 Issue 9 Pages 1429-1435
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    LNCap, a human prostate cancer cell line, possess androgen dependent growth characteristics. We studied anchorage independent proliferation of LNCap cells using semi-solid agarose double layer culture.
    The cells formed colonies in the semi-solid medium supplemented with charcol filtered steroid free fetal calf seriim and maximal colony formation was obtained in the medium with 10% serum. The addition of several steroids (testosterone, dihydrotestosterone, etinylestradiol) influenced the colony formation. Testosterone at the concentration of 10-8M to 10-10M stimulated colony formation with optimanof 10-9M.
    When LNCap cells were placed under the basal layer of the semi-solid culture as feeder cells, also stimulated was the colony formation of the LNCap cells cultured in upper layer of semi-solid medium.
    The addition of EGF, TGFα and TGFβ to the medium also stimulated the colony formation. The combined effect of EGF and TGFα was shown to be cooperative with testosterone. TGFβ, however, did not show such cooperative effect with testosterone on colony formation. The addition of the anti-body to EGF, TGFα or TGFβ to the medium decreased the colony formation of LNCap cells.
    These results suggest that LNCap cells excrete EGF, TGFα, TGFβ and/or similar substances and these factors autocrinely decorate the cell proliferation of LNCap human prostate cancer cells.
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  • Yoshihiro Hasui, Takahiko Kobayashi, Yasuhiro Yamashita, Shohei Nishi, ...
    1992 Volume 83 Issue 9 Pages 1436-1441
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The significance of vessel invasion by cancer of the renal pelvis and ureter was estimated with surgical specimens of 45 patients. The vessel invasion by cancer was observed in 25 out of 45 cases (55.6%). The incidence of vessel invasion increased with the grade of cancer and the extent of the primary tumor. The postoperative metastases by cancer was noted in 22 of the 25 patients with vessel invasion (88%) and in 4 of 20 (20%) patients without vessel invasion. The incidence of metastases in patients with vessel invasion was significantly higher than that without it (p<0.01). The 5-year survival rate was 13.1% in the patients with vessel invasion and 80.6% in the patients without it (p<0.005). Postoperative chemotherapy had no effect on the unfavorable outcome of the patients with vessel invasion. Therefore, vessel invasion by cancer may be one of the prognostic factors in renal pelvic and ureteral cancer. The patients with vessel invasion should be treated with more aggressive therapy to improve the poor prognosis.
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  • Nobuyuki Kondoh, Norio Meguro, Hisakazu Kiyohara, Miko Namiki, Akihiko ...
    1992 Volume 83 Issue 9 Pages 1442-1447
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Mitotic chromosomal analysis was done on 130 cases of male infertility, 85 with azoospermia and 45 with oligospermia. Eighteen cases of chromosomal aberrations were found, consisting of eight cases of Klinefeiter's syndrome, four with 46, XYq-(including one mosaic case), three translations, one with 47, XYY, one with 46, XY, 15p+ and one with normal variant. Among these, 46 XYq- is a notable karyotype because it cannot be accurately diagnosed without Q-banding, and because 46, XYq- is important for determining the role of the locus on the long arm of the Y chromosome which is supposed to include spermatogenesis. Eleven cases of 46, XYq- in azoospermic males, including our cases, have been reviewed in the Japanese literature. Statistical analysis of the values of testicular volume and serum hormones in these azoospermia cases, revealed obvious differences between normal and abnormal karyotypes and also between 46, XYq- and Klinefeiter's syndrome.
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  • Yasuyo Nishikawa, [in Japanese], Hirokazu Suzuki, Fumio Suzuki, Hidesh ...
    1992 Volume 83 Issue 9 Pages 1448-1451
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Under ultrasound guidance 79 simple renal cysts in 65 patients were punctured and aspirated with our contriveance, a 5 Fr single J catheter on a 19 gauge neele. Forty-eight renal cysts were successfully punctured, that is, they had no bloody fluid and did not have any leakage of contrast medium. These cysts were instilled with absolute ethanol for 5 minutes. To follow up the patients, consecutive observation was done by sonography or CT every three months.
    Ethanol-instillated renal cysts were more markedly reduced (reduction rate: 93±17%) than not-instilled cysts (reduction rate: 32±28%). Thus, ethanol-instillation was useful in the reduction of renal cysts. After the puncture of cysts, hematuria disappeared in most patients.
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  • Katsuyuki Matsuki, Hideyuki Akaza, Yoshio Aso
    1992 Volume 83 Issue 9 Pages 1452-1458
    Published: September 20, 1992
    Released: July 23, 2010
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    In previous studies, it has been suggested that the suppression of testicular androgen had inhibits bladder carcinogenesis. In this study we investigated which phase of bladder carcinogenesis is inhibited by the hormonal change of the hypothalamus-pituitary-testicular axis induced by the depot form of the LH-RH agonist.
    All rats were treated with 0.05% BBN in tap water for 8 weeks and were observed for the following 16 weeks. They were divided into five groups. Group 1(Control group); The LH-RH agonist was not administered. Group 2 (Initiation group); The LH-RH agonist (depot form) was administered subcutaneously two weeks before and after the initiation of the experiment. Group 3. (Promotion group); The LH-RH agonist (depot form) was subcutaneously administered at intervals of 4 weeks starting 6 weeks after the initiation of the experiment. Group 4 (Full term group); The LH-RH agonist (depot form) was administered subcutaneously at intervals of 4 weeks starting from 2 weeks before the initiation of the experiment. Group 5 (Castration group); Bilateral orchiectomy was performed one week before the beginning of the experiment. From our results, the followings were suggested, (1) more intensive inhibition of bladder carcinogenesis was observed in the group which received the LH-RH agonist (depot form), compared with the Castration group, (2) the bladder carcinogenesis was more intensively ihnibited when the LH-RH analogue (depot from) was given in the promotion phase and (3) not only testosterone but also the regulatory system of the hypothalamus-pituitary-testicular axis is related to the bladder carcinogenesis. And (4) a possibility was suggested that the LH-RH agonist (depot from) directly inhibited the bladder carcinogenesis.
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  • Jiro Shimoda
    1992 Volume 83 Issue 9 Pages 1459-1468
    Published: September 20, 1992
    Released: July 23, 2010
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    Bombesin (BMBS), a tetradecapeptide isolated from frog skin, and its antibody were evaluated in vivo and in vivo for their growth modulating effects on human prostatic carcinoma cell lines DU-145 and PC-3. The two cell lines were maintained in DME medium containing 2% FCS and 1μg/ml insulin in a humidified atmosphere of 5% CO2/95% air at 37°C. BMBS added at 0.1-10.0nM caused a striking shift of the concentration-dependent increase in cell growth of DU-145 and PC-3 in the absence of any other exogenously added growth factors. The addition of 1:250 antibody versus BMBS (Ab-BMBS; rabbit antiserum) to the medium during the lag phase of growth resulted in specific inhibition of growth of DU-145 and PC-3 with or without BMBS. Nude mice were transplanted with DU-145 cells in order to evaluate the suppressing qualities of Ab-BMBS on carcinoma cells in vivo. After the inoculation of 107cells/mouse DU-145 into nude mice, 20μl/mouse Ab-BMBS was intraperitonealy injected into mice three times weekly for three weeks. In mice administrated with Ab-BMBS, the growth of DU-145 was suppressed markedly. By immunocytochemical study, BMBS immunoreactivities were detected on DU-145 and PC-3 cells.
    These results suggest that BMBS can function as an autocrine growth factor for human prostatic carcinoma cells. Furthermore, on xenografts in mice, Ab-BMBS inhibits the increase of human prostatic carcinoma.
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  • Takeo Kohama
    1992 Volume 83 Issue 9 Pages 1469-1477
    Published: September 20, 1992
    Released: July 23, 2010
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    Input neuronal structures to the nucleus locus subcoeruleus (LSC) and the nucleus reticularis pontis oralis (PoO) were investigated by the horseradish peroxidase (HRP) study in cats. Under halothane anesthesia, a double barreled electrode was inserted into the LSC where electrical stimulation increased bladder capacity and the external urethral sphincter muscle activity, and into the PoO where chemical stimulation with carbachol increased bladder capacity and decreased the external urethral sphincter muscle activity. After identification of these regions, the HRP was ionphoretically injected into the LSC or PoO. By injecting the HRP into the LSC, retrogradely HRP labeled cells were. located broadly in the frontal, rectal, orbitalis, rostral cingulate, internal aspect of posterior sigmoidal and anterior sylvian gyli, nucleus corticomedialis of amygdala, lateral area of the hypothalamus, paraventricular hypothalamic nucleus, substantia nigra, periaquductal gray, reticular formation of the mesencephalon, pons and medulla, cerebellar nuclei and intermediate gray of the spinal cord. By injecting the HRP into the PoO, retrogradely HRP labeled cells were located broadly in the frontal, rectal, arbitalis, internal aspect of the posterior sigmoidal and anterior sylvian gyli, lateral area of the hypothalamus, paraventricular hypothalamic nucleus, periaqueductal gray, reticular formation of the mesencephalon, pons and medulla, cerebellar nuclei and intermediate gray of the spinal cord. These areas where HRP labeled cells were located mostly corresponded to the areas where electrical stimulation evoked either bladder relaxation or contraction in the previous reports.
    The LSC and the PoO seem to perform important roles in the neuronal mechanism for urine storage, receiving the inputs which facilitate or inhibit micturition from the extended areas between the cerebral cortex and the sacral spinal cord.
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  • Takeo Kohama
    1992 Volume 83 Issue 9 Pages 1478-1483
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Output neuronal structures from the nucleus locus subcoeruleus (SLC) and the nucleus reticularis ponts roalis (PoO) were investigated by the wheat germ agglutinin-horseradish peroxidase (WGA-HRP) study in cats. Under halothane anesthesia, a double-barreled electrode was inserted into the LSC, PoO. After identification of these regions, the WGA-HRP was injected ionphoretically into the LSC or PoO. WGA-HRP labeled fibers were observed from the hypothalamus to the sacral spinal cord. Fiber connection was assumed between the WGA-HRP injection sites and areas where WGA-HRP labeled cells were located. There were input and output relationships between the LSC, the PoO and the nucleus locus coeruleus alpha which is the pontine micturition center. By injecting the WGA-HRP into the LSC, two major rostral pathways and four major caudal pathways from the LSC were recognized. Two short caudal pathways projected into the cerebellum and the nucleus raphe magnus. Two long caudal pathways passed through the ipsilateral ventral and contralateral funiculi, and projected into the sacral intermediate gray and the Onuf's nucleus. By injecting the WGA-HRP into the PoO, two major rostral pathways and four major caudal pathways from the PoO were recognized. Three short caudal pathways projected into the cerebellum, contralateral reticular formation of the brain stem and the ipsilateral nucleus reticularis gigantocellularis. One long caudal pathway passed through the ipsilateral ventral funiculus and projected into the sacral intermediate gray and the Onuf's nucleus. From these results, the LSC and the PoO seem to send and receive outputs and inputs each other and to integrate the informations. Furthermore, outputs from the LSC and the PoO suppress bladder contraction with projection into the sacral spinal cord, and regulate the external sphincter muscle activity during urine strorage.
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  • Kyoichi Imai, Takanori Suzuki, Jun Kuribara, Kazuto Ito, Nobuaki Ootak ...
    1992 Volume 83 Issue 9 Pages 1484-1489
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The significance of prostatic specific antigen (PSA) was investigated in the subjects examined by the mass screening for prostate cancer from 1985 to 1990. All subjects was examined by digital rectal examination (DRE) and with prostatic acid phosphatase (PAP) and the subjects in whom prostate cancer (Pca) was suspected from abnormal DRE and/or elevated PAP were recommended to receive the secondary screening to confirm the presence of Pca. PSA was measured by radioimmunoassay using Ball-Elsa-PSA-kit. 1, 600 serum samples were obtained from our serum bank.
    The relationship among PSA, prostate size estimated by DRE and age was investigated. PSA was increased with age and the prostate size, PSA being more closely related with the latter. Therefore, we estimated that PSA has an ability to detect benign prostatic hypertrophy (BPH) in the mass screening. This estimation should be confirmed by using an ultrasound tomography because the prostate size obtained by DRE is inaccurate as compared with that obtained by ultrasound tomography.
    The cut off level of PSA was determined by control which was composed from the subjects with normal size prostate and one with BPH. When the cut off level was 8.6ng/ml, the sensitivity, specificity and efficiency as Pca marker was 73.9%, 97.4% and 97.1%, respectively. PSA was more than 8.6ng/ml in all of Pca with elevated PAP. PSA was expected to improve the Pca detection rate in our mass screening system.
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  • Akira Kimura, Yoshio Aso
    1992 Volume 83 Issue 9 Pages 1490-1498
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    A software for a lap top computer to display prostatic contour three-dimensionally based on transrectal ultrasonograms was developed, and its clinical usefulness was examined.
    The prostatic contour of a case with prostatic cancer showed a typical irregular surface, and that of a case with prostatic hypertrophy had a smooth spherical shape, while that of a normal case had a flat shape. Each showed its characteristic shape. Estimation of the prostatic weight by assuming that the prostatic contour has ellipsoidal contour is a simple method for prostatic weight measurement, but it has a tendency to underestimate the weights, especially in normal cases. Three-dimensional display of the contour of prostatic cancer, prostatic hypertrophy, and normal prostate revealed that it could be estimated as allipsoid in prostatic cancer or hypertrophy, while the normal prostatic contour was too flat to be calculated as such.
    Among 52 patients with benign prostatic hypertrophy who underwent transrectal ultrasonotomography before and during the anti-androgen therapy more than three time, nine cases showed transient reduction of more than 30% in prostatic weight and then reeniargement of more than 30%. In these cases, three-dimensional display of prostatic contour was done. The display was useful to visualize clearly which part reenlarged.
    Therefore, usefulness of the three-dimensional display of the prostate was verified.
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  • Tsuyoshi Kobayashi, Tsuneo Kawai, Yuichi Tachibana, Tamio Yamauchi, Ta ...
    1992 Volume 83 Issue 9 Pages 1499-1505
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Thirty five cases with stage B prostate cancer underwent radiotherapy to the primary lesion from 1965 to 1989 in our hospital. Twenty two of them were given radiotherapy alone and 13 were treated by radiotherapy combined with hormone therapy. Twenty nine of them were given 113 or 127 TDF (Time, Dose and Fraction) of external radiotherapy using linear accelerator. Three of the other 6 cases underwent external radiotherapy combined with administration of bleomycin and the others received intraoperative irradiation by electron beam. We defined on digital examination a reduction in the primary lesion as improvement and complete flattening as atrophy for evaluation of the treatment.
    Rates of the improvement were 95% in radiation, alone, and 100% in hormone and radiation combination. Atrophy rates were 62% in the former, and 92% in the latter. Five-year non-relapse rates were 85% and 100%, respectively.
    Four cases relapsed in the radiotherapy alone group, in which two cases given intraoperative irradiation relapsed in the primary lesion and another two given extrenal radiotherapy in the pelvic nodes and required further treatment. One of the 2 relapsed cases with intraoperative irradiation has been alive with cancer and the other died from dissemination. One of the 2 relapsed cases with external radiotherapy has been alive and well and the other died at home without any information of death.
    One relapsed in the combination group at 130 months but has been alive despite gradually progressive dissemination for 185 months.
    All relapsed cases were those with atrophy group. No relapse was seen in cases without atrophy of the prostate. Five-year and 10-year actuarial survival rates were 80% and 62% in all stage B, 90%, 71% in the radiotherapy alone group, and 63%, 47% in the combination group, respectively. The only patient who died from the prostate cancer in all our stage B series was the one given intraoperative irradiation. The planned radiation dose were accomplished in all cases. Side effects of radiation were minimal and transient without severe persistent sequelae. The result of our radiotherapy for stage B was almost similar to that of radical prostatectomy.
    We conclude that for the stage B prostate cancer radiotherapy alone is an appropriate first-line treatment and that close follow up of the pelvic nodes is mandatory, with additional therapy initiated only when the metastasis is found.
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  • Hiroshi Okada, Jiro Miyazaki, Sadao Kamidono
    1992 Volume 83 Issue 9 Pages 1506-1510
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    With increasing number of chronic hemodialysis (HD) patients, urologists share much more chance to encounter HD patients who need urological operations. In these patients healing of surgical wound was sometimes hampered by intractable infection. In this paper we investigated granulocyte functions of HD patients. Thirty two male HD patients (20-50 years of age) and 18 healthy volunteers, who had no infectious foci and had no anti-inflammatory drugs were adopted. Heparinized blood samples were drawn between 8:00 and 9:00am from the volunteers, and just before HD from the HD patients. The oxygendependent microbicidal response of granulocytes was evaluated by luminol dependent chemiluminescence which measured the amount of superoxide produced by opsonized zymosanstimulated granulocytes. Phagocytic function of granulocytes was evaluated by counting the number of granulocytes which phagocytized fluorescent monodisperse carboxylated microsphares by flowcytometry. Superoxide production per 1000 granulocytes of HD patients was significantly higher than that of normal control. During HD superoxide production was temporally decreased for the first one hour, became maximal at the end of HD and returned to the baseline level on the second post HD day. Phagocytosis was significantly depressed in HD patients. This functional deficit could lead to prolonged healing of infection in HD patients.
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  • Katsuyuki Sano, Taro Shuuin, Masahiko Hosaka, Tadashi Ikegami, Yukio S ...
    1992 Volume 83 Issue 9 Pages 1511-1516
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    For the purpose of examining the Topoisomerase II (Topo II) activity in human kidney cancer cells, we performed experiments with using DNA unknotting method. This method check relative Topo II activity with its conversion of knotted form P4 phage DNA to unknotted form. Our preliminary results demonstrate remarkable activity of Topo II with specific conversion of knotted form P4 DNA to unknotted form in human kidney cancer cells, YCR and ACHN. Moreover, addition of etoposide to the same experiment suppressed Topo II activity in a dose dependent manner. Our results suggest that kidney cancer has a certain amount of Topo II, a target for etoposide. We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.
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  • Hiroshi Hara, Minoru Kurita, Yoshinori Kitazumi, Hajime Morioka, Kanam ...
    1992 Volume 83 Issue 9 Pages 1517-1520
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    A male aged 48 visited our department on October 17, complaining of swelling of his left scrotal content from July, 1990. Physical examination showed the testis to be swoller to the size of a chicken egg, and ultrasound examination disclosed the swelling to be solid and nodular. Left high inquinal orchiectomy was performed on October 29. The testis extirpated was 50×40×45mm in size and weighted 80g; the gross appearance of the cut surface of the testis was nodular with grayish-white color. The lesion was proved to be spermatocytic seminoma histopathologically, but no hemorrhage or necrosis was observed. Radiation in the dose of 36 Gy was given over the left hypogastrium and paraaortic region in 36 Gy each. The patient subsequently did will and has been followed up in our outpatient clinic without evidence of recuurence as of 10 postoperative months.
    This patient was the 19th reported case of spermatocytic serminoma in Japan. However, General Rules for Clinical and Pathological Studies on Testicular Tumors explain that spermatocytic seminoma is usually seen in a pure form, unassociated with other types of germ cell tumors, making our case actually the 17th case of this particular seminoma if spermatocytic seminomas combined with other germ cell tumors are exclude from the statistical analysis. Reports of spermatocytic seminoma thus defined are reviewed in this study.
    Our study shows that compared with typical seminoma, spermatocytic seminoma is characterized by its occurrence in older men, bilaterality of the lesions, and favorable prognoses, and that whether the disease is of single histological type or combined with other tumor tissues or not is an essential factor in deciding its treatment and prognosis. However, a long term follow up of the patients is needed for deciding the adequacy of the treatment and exact prognosis.
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  • Hisashi Matsushima, Kimio Fujita, Tsuyoshi Kunitake, Masahiro Nanano, ...
    1992 Volume 83 Issue 9 Pages 1521-1524
    Published: September 20, 1992
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Two cases of renal lymphoma were reported. Case 1 was a 73-year-old, and case 2 was a 59-year-old female. Their chief complaint was flank pain. The findings obtained by CT and angiography were not compatible with renal cancer. The tentative diagnosis of case 1 was inflammatory disease or soft tissue tumor, and that of case 2 was renal subcapsular tumor. Histological specimen was obtained by open biopsy from case 1, and by nephrectomy from case 2. Immunohistochemical surface marker study revealed both tumors were B cell lymphoma. Chemotherapy (CHOP-Bleo, or PPA) in both cases and additional radiotherapy in case 2 markedly reduced the tumor size. Nevertheless, case 1 died 5 months later from reccurrence, and case 2 died 14 months later of gastrointestinal bleeding. At autopsy, the renal subcapsular layer was infiltrated by lymphoma cells in both cases, and lymphadenopathy was not observed.
    Reviewing 16 cases previously reported as renal lymphoma, the capsular or subcapsular diffuse infiltration to the kidney is considered to be a characteristic feature of renal lymphoma.
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