The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
Volume 85 , Issue 6
Showing 1-17 articles out of 17 articles from the selected issue
  • Kozo Sugimoto
    1994 Volume 85 Issue 6 Pages 911-917
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    RBT-K5 cell line was established from a male Wistar rat bladder tumor induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. RBT-K5 (ADM res.) cell line, adriamycin (ADM) resistant, was also established from RBT-K5 cells by stepwise escalation of ADM concentrations in vitro. In this study, we have examined the effect of verapamil (VR) on intracellular ADM concentration in these cell lines. The viability of RBT-K5 cells was significantly lower than that of RBT-K5 (ADM res.) at the concentration from 0.5 to 4μg/ml of ADM. The cytotoxic effect of ADM was enhanced by the addition of VR in the both cell lines. The intracellular ADM concentrations of RBT-K5 and RBT-K5 (ADM res.) were increased from 607.7±74.1ng/106 cells to 1152.1±187.6ng/106 cells (1.9-fold) and from 185.1±36.5ng/106 cells to 751.5±258.4ng/106 cells (4.1-fold), respectively, 24 hours after incubation in the presence of 10μg/ml of VR. Furthermore, the intracellular ADM concentration was maintained at high-level in combination with VR even after the removal of ADM from culture medium. These results suggest that the combination therapy with VR is more effective against ADM-resistant than ADM-sensitive bladder tumor.
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  • Takao Ikeuchi, Keiichi Matsumoto, Yasutada Onodera, Yoshio Kai, Ryuzo ...
    1994 Volume 85 Issue 6 Pages 918-924
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The degree of damage on the peristomal skin of 42 patients who accepted the uro-stomy was visually and histologically evaluated. The incidence of damages on the areas of the skin where the materials was applied was 85.7%. The occurance of non-active lesions (mainly permanent pigment change) was statistically more significant than the active lesions (mainly redness) [p<0.05]. The incidence of skin lesions using the skin barrier agents was significantly lower statistically than the incidence with the adhesive medication indicating a superior treatment for the skin condition [p<0.05]. Although the gross appearances were normal, the microscopic and electron microscopic evaluations detected chronic damages indicating comparatively evident changes.
    The results suggest that these histological evaluations are useful in examining the damage on peristomal skin.
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  • Kazuo Kumano, Wihua Wang, Tadao Endo
    1994 Volume 85 Issue 6 Pages 925-931
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The beneficial effect of UW solution may result from its ability to prevent tissue edema during cold storage. This study was conducted to determine which impermeant was effective in this regard during cold storage of a rat kidney in solution. Functional and morphological studies were made on a rat isolated perfused kidney (IPK) following 24 hour-cold storage in various tested solutions. Right nephrectomy was performed in 95 male rats by the method of Nishitsutsuji-Uwo et al and the kidney was perfused and stored at 4°C for 24 hours as follows: glucose (194mM) as a control, mannitol, sucrose, raffinose (140mM in each), lactobionate (100mM), raff+lact, hydroxyethyl starch 20, 40 (5%) with electrolyte composition essentially the same as that of EuroCollins or UW solution. Kidneys stored for 24hrs at 4°C were perfused by the IPK apparatus. The perfusate flow rate was adjusted to maintain the renal arterial perfusion pressure at 100mmHg. Raff, raff+last or UW solution showed significantly higher fractional reabsorption of sodium than the control with no change in renal hemodynamics. The release of LDH into the perfusate was significantly less in raffinose than the control. Raffinose may thus be considered to function effectively as an impermeant for cold kidney preservation and molecule size would appear more important than negative charge for rat kidney preservation.
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  • Kikuo Akiyama
    1994 Volume 85 Issue 6 Pages 932-937
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The volume of the seminal vesicles in 413 males, who were submitted to a mass screening program for prostatic diseases by transrectal sonography, was measured by tracing ultrasonograms using a multiplanimeter. Ages of the subjects ranged from 46 to 88 years (mean age 67.0 years).
    The mean volume of the seminal vesicles for all cases was 14.55±5.11cm3. The volume of the seminal vesicles was not related statistically to the height, body weight and body mass index of the subject. The volume of the seminal vesicles in cases of no prostatic diseases decreased with age, while that of cases of benign prostatic hypertrophy increased with the progress of the disease.
    These facts suggested that the seminal vesicles were androgen dependent, similar to the prostate.
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  • Toshiyuki Kamijo, Toshikazu Sato, Ryozo Yanagizawa, Hiroichi Kishi
    1994 Volume 85 Issue 6 Pages 938-944
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The expression of the proliferating cell nuclear antigen (PCNA) was analyzed in formalin-fixed paraffin-embedded materials of 20 primary renal pelvic and ureteral cancers. The relation between PCNA positive rate and clinical pathological stage and prognosis were investigated. The fraction of PCNA positive nuclei ranged between 1.6-64.4% (mean 25.1%). The PCNA positive rate was found to be related to established prognostic factors, but not to patient age, sex and length of time for paraffinembedded. Grade 3 cancers showed a higher fraction of PCNA positive nuclei than grade 1 and 2 cancers (p<0.05). Superficial cancers showed a significantly lower fraction on nuclei positive for PCNA than invasive cancers (p<0.01). The cancers with lymph node metastases showed a higher fraction (p<0.05). The cancers with distant metastases postoperatively, also had a higher fraction (p<0.05).
    As PCNA immunostaining can be applied to routinely processed paraffin-embedded specimen, this method is very useful to assess the cell proliferation. The results suggest that the fraction of PCNA positive nuclei would be useful for investigating the malignant potential, of renal pelvic and ureteral cancers thereby providing prognostic factors of these diseases.
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  • Takeshi Yanagisawa, Tadashi Suzuki, Tatsuya Kudoh, Song Chol Oh
    1994 Volume 85 Issue 6 Pages 945-952
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The effect of intravesical Bacillus Calmette-Guérin (BCG) on N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) induced urinary bladder carcinogenesis was pathologically evaluated. As a suppressive study of BCG on initiation, F344 female rats given 0.05% BBN orally for 6 weeks had intravesical insitillation of either BCG or saline 3 times during BBN administration (Group A). As an inhibitory study of BCG on promotion, F344 female rats given the same strength of BBN for 10 weeks had intravesical instillation of either BCG or saline 4 times starting at 7th week of BBN administration (Group B). The bladders were extirpated at 18th or 36th week after BBN administration in Group A and at 10th or 18th week in Group B. The lesions in the bladder were classified into 4 pathological findings; simple hyperplasia, papillary or nodular hyperplasia, papilloma and transitional cell carcinoma. The incidence of the lesions and the number of the lesions per 10cm basement menbrane were observed. BCG did not inhibit the growth of transitional cell carcinoma in Group A nor in Group B, rather partly promoted carcinogenesis. These results indicate that BCG have no inhibitory effect on carcinogenesis. We concluded that prophylactic effect of intravesical BCG is not due to inhibition of carcinogenesis but elimination of residual tumors by strong antitumor effect of BCG.
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  • Hirofumi Matsuoka, Ichiro Kajiwara, Haruo Tahara, Kazuhiro Oshima
    1994 Volume 85 Issue 6 Pages 953-957
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    The present study has been carried out to clarify relationship between phimosis and urinary tract infection or vesicoureteral reflux.
    The subjects consisted of 654 boys up to 15 years old with phimosis who had been treated at the outpatient division, Fukuoka University Hospital during 13 years from 1974; 393 boys (60%) with false phimosis, 261 boys (40%) with true phimosis. Thirty three cases (5%) had abnormal voiding (weak stream, preputial ballooning, dribbling etc.)
    Boys with true phimosis without abnormal voiding showed high incidence of urinary tract infection compared with normal subject, and if these boys had abnormal voinding symptoms as well, the incidence of urinary tract infection, particulary in the form of pyelonephritis, was noted to be high. Therefore, we suggest that boys with phimosis should be treated surgically.
    The incidence of urinary tract infection in boys with false phimosis were similar to normal group.
    All cases except one of vesicoureteral reflux accompanied by true phimosis was diagnosed as primary reflux cystoscopically. Therefore in most cases of phimosis associated with reflux, phimosis is determined to be only an accessory factor of vesicoureteral reflux. And refluxing patients should be worked up for urinary tract infection after they have had circumcision. Only in one boy with phimosis and reflux, was the reflux thought to be secondary reflux caused by phimotic obstruction.
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  • Hiroshi Okada, Jiro Miyazaki, Sadao Kamidono
    1994 Volume 85 Issue 6 Pages 958-963
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Granulocyte function of patients on anti-cancer chemotherapy was investigated. Five bladder cancer patients, who had undergone M-VAC neo-adjuvant, chemotherapy were select for this study. Their tumor stage was T3M0N0 and peripheral blood granulocyte and platelet counts were more than 1500/mm3 and 10×103/mm4, respectively, before starting chemotherapy regardless of the course Flow-cytometric analyses were utilized to measure the function of phagocytosis and the ability to produce superoxide (bactericidal function) of granulocytes. During the course peripheral blood count, granulocyte function, urinalysis and blood chemistry were checked every other day and urine and blood culture were done once a week. Although the first couse of M-VAC was completed without using rhG-CSF, the second course of M-VAC administration required rhG-CSF when the number of peripheral granulocytes was below 1000/mm3.
    The function of phagocytosis decreased from the onset of the first course of M-VAC until the nadir of granulocyte number, then recovered close the prechemotherapy level by the time when the chemotherapy was completed with the increase in the number of granulocyte but remained relatively low until starting the second course. The function deteriorated more rapidly with the second course than with the first course, but recovered rapidly after administration of rhG-CSF and was significantly higher when the nadir of granulocytes was noted with the first course of M-VAC than with the second course. As for the function of superoxide production, it decreased gradually until the nadir of granulocyte during the first course and then continued to recover toward starting the second course but failed to return to the prechemotherapy level. With the second course it decreased as was noted with the first course but after administration of rhG-CSF recovered rapidly and became higher than it was when the nadir was noted with the first couse.
    This is the first report describing the change of granulocyte function (phagocytosis and superoxide production) during M-VAC chemotherapy and comparing them as they were with the first course (without rhG-CSF) with those with the second course (with rhG-CSF).
    The above results suggested that the initiation of rhG-CSF to patients on intensive anti-cancer chemotherapy could be withheld until their peripheral blood granulocyte concentration became below 1000/mm3 in order to preserve their appropriate granulocyte function.
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  • Hiroyuki Jimbo, Yoshihiro Totsuka, Tooru Mashimo, Tomokazu Umeyama, Hi ...
    1994 Volume 85 Issue 6 Pages 964-967
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    From August 1991 to February 1993, a total of 114 men with mean age of 68 years underwent ultrasound guided systematic biopsy of the prostate. These patients were clinically suspected of having prostate cancer by elevated PA or digital rectal examination. Systematic biopsies were performed on two different sites of peripheral zone and transition zone of each lobe, and echographycally detected hypoechoic area was also biopsied. There were 42 prostate cancers detected: 7 (30%) in 23 men between 50 and 59 years old, 17 (45%) in 38 men between 70 and 79 years old, 6 (55%) in 11 men more than 80 years old. Three (11%) were detected in 27 men with a PA level of less than 3.1ng/ml, 39 (45%) were detected in 89 men with a PA level of no less than 3.1ng/ml. Thirty-three (44%) were detected in 75 men with positive rectal examination. Non-palpable cancers were detected in 9 men. These results suggest that systematic biopsy may be useful and a sensitive means in detecting prostatic cancer.
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  • Masao Tsujihata, Osamu Miyake, Hiroshi Itoh, Hiroaki Itatani
    1994 Volume 85 Issue 6 Pages 968-973
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    We performed tumor enucleation in 21 patients of renal tumors from Jan. 1980 to Feb. 1993. Of them 19 had renal cell carcinoma. We reviewed the results of clinical experiences.
    Preoperatively, all patient underwent ultrasound, computerized tomography (CT) and angiography, and evaluated tumor characteristics in terms of its localization, size and pre or absence of psudocapsule. All cases were shown to be well encapsulated.
    Of them 17 were asymptomatic and detected incidentally, whereas remaining one case was bilateral renal cell carcinoma clinically characterized by gross hematuria. This case was treated by radical nephrectomy on the right side and enucleation of the tumor on the left side.
    All cases had localized renal cell carcinoma (stage 1) of low grade (15 cases of grade 1 and 3 of grade 2), and the diameter of the tumor averaged 3.4cm.
    Of 18 cases 2 died, one died of causes unrelated to RCC and the other of the metastasis of bilateral RCC after nephrectomy. The 16 cases are presently free of disease for maximal follow up period of 92 months. We consider that tumor enucreation will be indicated for tumors found incidentally, surrounded by pseudocapsule, of small size (less than 3.0cm in diameter), and of low grade and low stage, and that tumor enucreation for renal cell carcinoma could be curative yet preserve renal function in selected patients.
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  • Makoto Hata, Hitoshi Yanaihara, Kunihiro Hayakawa, Masakazu Ohashi, Hi ...
    1994 Volume 85 Issue 6 Pages 974-980
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    At our medical center we have seen 151 patients who have undergone adrenalectomy from 1971 up until June 1992. There has been a recent increase in the number of cases since 99 patients have been seen in the last eight years from 1985. This increase is related to the increase in the number of incidental tumors. Of those 99, 26 have been incidental tumors. Twenty-four of those have been endocrine inactive tumors, and the remaining 2, both active endocrinologically, were pheochromocytoma.
    We propose that our tentative indications for surgical treatment of incidental tumors are 1) tumors of diameter 3.5cm or greater, 2) tumors undeniably malignant by imaging diagnosis, 3) tumors that tend to increase in size with every six-month re-examination, even though the original size is less than 3.5cm in diameter, and 4) tumors endocrinologically active.
    The main purpose of this study was to make a differential diagnosis of malignant tumors among incidental tumors. Diagnostic modalities included 1) imaging diagnosis such as echography, CT, MRI, and angiography, 2) analysis of DNA ploidy and BrdU uptake utilizing flow cytometry of excised adrenal tumor tissues, and 3) analysis of urinary steroid fraction.
    It is generally thought that there are currently no methods by which malignant tumors can be differentiated with certainty, even with modern diagnostic technology, and review of the literture, finds approval or disapproval with regard to the methods we selected to evaluate tumors. What has aroused interest in our results is urinary 17KS fraction. Cases of canser exhibiting high values are limited to the fraction in which the 5-hydroxyl group of the steroid nucleus is in β-position. Although the number of cases is still small, it is our hope this finding will provide a clue to establish useful method for the differential diagnosis.
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  • Masamichi Hayakawa, Tadashi Hatano, Yoshihide Ogawa, Yuzou Koyama, Ken ...
    1994 Volume 85 Issue 6 Pages 981-989
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    We modified Studer's bladder substitute technique and constructed continent urinary reservoir for 7 patients with bladder tumors after transprostatic cystoprostatectomy. Studer's bladder substitute technique is characterized by both a tubular isoperistatic proximal limb of 20cm of the ileum in continuity with the pouch constructed using the detubularized ileum and the ureters reimplanted into the proximal part of the limb using a simple lateral anastomosis of the ureters to the end of the limb. Our modifications, transprostatic resection, was that distal one third or fourth of the prostate was left after cystoprostatectomy followed by either enculeation of the whole residual prostatic tissue including the urethra (type II) or sharp resection of the tissue leaving the urethra (type III). A small hole in the lowest part of the pouch was anastomosed either to the residual prostatic capsule (type II) or to the residual prostatic urethra (type III). Our modified Studer's technique was simple, easy to perform, and had low risk of massive bleeding especially from the central vein overlying the appex of the prostate.
    Clinical results were as follows; 1) all patients were satisfied with the passing of their urine per urethra without any cutaneous stoma, 2) no patients had clinical signs of pyelonephritis after discharge, 3) urine was not infected. 4) four out of 5 patients younger than 65 years old maintained potency, 5) voiding varies with maximum flow rates of 4.2m/lsec to 33.6ml/sec, and an average flow rate in 3 patients (type III) was 24.5±6.9ml/sec as compared to 13.0±1.3ml/sec in 3 patients (type II), 6) simultaneous pressure recording in the pouch and the rectum showed that pressure within the pouch was almost the same as pressure in the rectum during urination and did not exceed 45cmH2O when the pouch was filled to capacity, and 7) all of the 7 patients achieved perfect day-time continence while 3 patients complained of night-time spotting or leaking which improved with the patients waking up at night to void.
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  • Kenji Shimada, Shyozo Hosokawa, Kazuhiro Sakaue, Yoko Kishima, [in Jap ...
    1994 Volume 85 Issue 6 Pages 990-995
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    After 16 weeks of gestation, amniotic fluid mainly consisted of fetal urine. Therefore, the association of oligohydramnios with fetal urinary tract abnormalities implies severe deterioration of renal function. The relationship of the kidney and amniotic fluid in pulmonary development has been investigated, and fetuses with oligohydramnios starting in the second trimester are considered to have uniformly fatal outcomes. We analysed underlying urological disorders, gestational age at presentation, and ultimate outcomes in 45 fetuses with severe oligohydramnios, and especially focused on clinical courses and prognosis of 7 surviving patients.
    Clinical and/or autopsy diagnosis included bilateral renal hypodysplasia in 20 patients, urethral atresia with/without prune belly deformity in 9, posterior urethral valve in 6, polycystic kidney disease in 4, hydrometrocolpos in 2, hereditary renal dysplasia in 2, and the others. The average gestational age at detection of severe oligohydramnios was about 30 weeks, ranging from 16 weeks in patient with urethral atresia.
    Urological disorders of 7 surviving patients consisted of 4 posterior urethral valves, one hydrometrocolpos, one hydronephrosis of the solitary kidney, and one bilateral megaureter. In these 7 patients severe oligohydramnios strated in the third trimester. Four patients required ventilator suppors together with the administration of surfactant, but they were weaned in one to 4 days. There was no evidence of pulmonary hypoplasia on chest X-ray films. Urological emergency drainage was necessary in all patients on the day of delivery to 2 days postnatally. One patient with posterior urethral valve developed ESRF 6 months after birth. Two patients have a normal serum creatinine, but another 4 have slight elevation of SCr for their age.
    Of 38 patients who died of respiratory failure at perinatal periods, autopsy was done on 31 and lung weight ratio was measured. Lung hypoplasia in terms of lung-to-body weight ratio was apparent in 27 patients.
    Based on these experiences we have the policy to induce delivery in cases with third trimester onset of severe oligohydramnios from genitourinary abnormalities, and to start urological management early in neonatal periods.
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  • Katsutoshi Tanda, Nobuo Shinohara, Tatsuya Mori, Toshimori Seki, Katsu ...
    1994 Volume 85 Issue 6 Pages 996-1001
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    We report 4 patients, 1 female and 3 males aged 26-74 years, who underwent surgical treatment for renal malignant tumors with supradiaphragmatic extension into the vena cava. All of their tumor thrombi extended to the right atrium as confirmed by magnetic resonance imaging. The distinctive symptom was liver dysfunction caused by disturbance of the hepatic vein drainage in two patients. However, there was no common symptom in these 4 patients. Preoperative metastasis was found only in the female, whose metastatis was solitary in the lung and seemed to be able to be removed easily after radical nephrectomy. All of these 4 patients had radical nephrectomy and removal of the tumor thrombi with the use of cardiopulmonary bypass and temporary exsanguination. In 3 of these patients, the liver was mobilized to expose the retrohepatic vena cava by incision of the falciform, triangular and coronary ligaments. Two patients with vena caval wall invasion had vena cavectomy and an artificial vascular graft was then sutured to replace the caval wall in one of them. Preoperative liver dysfunction was gradually improved after operation and completely recovered about 1 week later. A postoperative complication, wound infection, occurred in only one patient. Pathological examination revealed renal cell carcinoma in 3 patients and nephroblastoma in the remaining one. In renal cell carcinoma, both patients without distant metastasis were alive about 15 months postoperatively. However, the one with lung metastasis died with newly appeared multiple metastases 9 months postoperatively. Although we expected a complete cure of adult nephroblastoma, he unfortunately died of systemic CMV infection due to severe myelosuppression after ajuvant chemotherapy and radiotherapy in the first 3 postoperative months. No evidence of nephroblastoma was found at autopsy.
    We believe that an extend operation for renal cell cancer with supradiaphragmatic involvement of the vana cava is warranted and provides reasonable long-term survival in properly selected patients.
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  • Hiroshi Okada, Noboru Tatsumi, Yasushi Nakano, Akinobu Gotoh, Hiroshi ...
    1994 Volume 85 Issue 6 Pages 1002-1005
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    Small cell carcinoma of the prostate is a rare disease, since only about 50 cases in the English literature and two cases in Japanese literature have been reported. Here we report a case that is the youngest ever described in the literature.
    A 24-year-old man was referred to our hospital with right dull lumbago and dysuria. He had the same symptom for one and half year before referral. IVP showed right non-visualizing kidney and left hydronephrosis. Form abdominal CT scans and cystoscopic findings a retrovesical tumor was highly suspicious. Transperineal needle biopsy specimens revealed an undifferentiated malignant tumor. His serum Neuron Specific Enolase (NSE) and LDH were remarkably high and whole body CT scan and upper GI tract examination demonstrated no lesion. He developed ileus and underwent exploratory laparotomy and colostomy was constructed. There was a large mass arising from the prostate which invaded into the peritoneal cavity, and multiple metastases were seen on the omentum and mesenteric lymph nodes. Specimens from the mass arising from the prostate and lymph nodes revealed small cell carcinoma pathologically. A panel of antibodies were used to seek potential tumor markers and to identify substances produced by the tumor cells including enzymes, cytoskeletal components and hormones. And stains were positive for the NSE and chronogranin.
    An intensive anti-cancer chemotherapy with VP-16 and CDDP was done with minor response (MR) and the serum tumor marker, LDH and NSE, decreased markedly. However, he had expired on the 58th hospital day.
    A cell line derived from this patient was established in our laboratory, and this cell line will contribute to a new therapy of this lethal disease.
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  • Tomohiro Ueda, Tamio Yamauchi, Susumu Kageyama, Masahiro Tsuzuki, Sato ...
    1994 Volume 85 Issue 6 Pages 1006-1009
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    A case of primary malignant lymphoma of the bladder is reported. A 70-year-old woman was admitted to our clinic with the chief complaint of intermittent gross hematuria on March 31, 1992. Examination of cystoscopy, IVP, ultrasonography and CT scan suggested a non-papillary invasive bladder tumor.
    Pathological examination of transurethral biopsy revealed malignant lymphoma, B cell type.
    After 5 courses of intraarterial COMPA (CDDP, VCR, MTX, PEP, ADR) chemotherapy, she have been in complete remission.
    Intraarterial COMPA chemotherapy might be effective and useful for primary malignant lymphoma of the urinary bladder.
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  • Kazunori Takase, Hitoshi Kitamura, Kenn Yuu, Yukio Nakatani, Yoshiaki ...
    1994 Volume 85 Issue 6 Pages 1010-1013
    Published: June 20, 1994
    Released: July 23, 2010
    JOURNALS FREE ACCESS
    A case of adrenal cyst with an immunohistochemical evidence of mesothelial origin is presented. A 73-year-old Japanese woman was referred to our hospital with a complaint of left flank pain. The diagnosis of left adrenal cyst was made based on the radiographic and hormonal examinations. The adrenal cyst was removed surgically. Histological examination revealed that the cyst was lined with either a single layer of squamous or cuboidal cells. In immunohistochemistry testing, the cells were positive for keratin and carbohydrate antigen 125, while they were negative for epithelial membrane antigen, vimentin, desmin, and factor VIII related antigen. Thus, the present case was classified as epithelial cyst of mesothelial origin.
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