The tubercle bacilli isolated from tuberculosis of the urological system of man and the bovine tubercle bacilli obtained from cattle were inoculated, in a very small dosis, i. e. 1/10 of 1/100mg., into the auricular vein of the rabbit and dealt upon the pathological findings of the testicles and epididimis of the animal (31 cases from the testicles and 2 from the epididimis), and obtained the follwing conclusions:
1) Among the 31 cases of the positive examinations, 15 cases (i. e. 48.47%) had been found to be tuberculosis of the testicles, which were indeed a remarkably high morbidity.
2) In the experimental cases, the testicles had been found infected to a very high percentage but then there were found some cases in which the primary infection of the epididimis developed mostly in the tail and also in the head.
3) Similar findings as in human cases in which tuberculosis of the epididimis involved the testicles after it had assumed a far advanced state, were also proved in experimental cases.
4) By the strains of the tubercle bacilli obtained from the urological, system, which had a very weak virulency by the rabbit, produced the features without producing infections. The testicles involvement only had been met with, but then it was only local and caused infiltration of the small round cells and the epitheloid cells in the connective tissues of the interstitium and began to involve the seminal ducts. Those strains of the tubercle bacilli having a high virulency in the rabbit, e. g. No. 17 (the rabbit No. 87, strain Suzuki C. ecp. I Communication) and the bovine tubercle bacilli that did not produce any tubercles in the intersti tiumof the testicles but diffuse small round cells and other cellular infiltrations.
5) In the experimental primary tuberculosis of the epididimis arising from the circulatory route, the foci seemed to develop in the subcutaneous layers of the ducts or the connective tissues of the interstitium.
6) If pathological changes are present in the testicles, small round cells, macrophages and the waste products are excreted into the ducts of the epididimis, which affected the epithelium of the seminal ducts and at length began to form the typical nodules either in the subcutaneous layers or the connective tissues of the interstitium or even if there were involvements in the testicles the infection did not occur from the excretory processes, but the infection of the epididimis occurred through the lymphatic system.
7) On the formation of the semen, it has been found that if the infection had been derived from the weakly virulent bacilli in the rabbit, even if there should have developed certain localized tubercular changes in the testicles, the formation of the semen would have occurred and yet the still normal seminal ducts had no derangement of the production of the semen. By the strains of the bacilli which had a high virulency in the rabbit, there would occur no remarkable pathological changes in the testiclular parenchyma, but the chronic atrophical changes and caused the derangement of the formation of the semen. It has however been observed that the formation of the semen occurred during a short interval of the observation of the experiment, i. e, within 21 days.
In short, by the use of adequate type of the bacilli and an adequate amount, the tubercle bacilli, when injectod into the vein of the rabbit, did not develop any general infection in the form of miliary tuberculosis, but experimental tuberculosis of the testicles and epididimis. The tubercle bacilli isolated from the urological cases, if they should be only weakly virulent in the rabbit, will produce the involvement in the epididimis as in the human cases of the urological tuberculosis when injected into the auricular vein of the rabbit in a very small amount in a very high morbidity and it has been learnt that it seemed very probable that there was visceral affinity in the tubercle bacilli.
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