Neoplasm of the prostate, especially hypertrophic prostate were studied histochemically by determining the activities of aconitase (AC), succinic dehydrogenase (SD), malic dehydrogenase (MD) and lactic dehydrogenase (LD).
The activity, playing an important role in the metabolism of citric acid which tends to be accumulated in the hypertrophic prostate, was evaluated in the various types of diseased prostate.
1) Activities of AC, SD, and MD were observed in the glandular epitherial cells and were considered to be related to the cellular function and proliferation.
2) Active type of prostatic hypertrophy reveals a greater AC activity in the tissue compared with normal or inactive type of the prostate.
Inactive type shows a smaller activity than in normal tissue, and the activity is diminished in the epitherial glands at the site of glandular spase which is markedly enlarged.
3) AC activity in the stromal nodule is apparently greater than in normal or inactive type of prostate tissue.
4) A conclusion is drawn from the results that the significance of AC activity in relation to morphopathologic changes of prostatic hypertrophy is following.
Citrate in tts nature tends to accumulate in the prostate, and it begins to increase as the formation of stromal nodule progresses.
In early stage of prostatic hypertrophy, citrate is seemed to be metabolised by a sufficient increase in AC activity. As the hyperplasia of the glandular component setsin, citrate become increased in the glandular cells which is counteracted by AC activity increase while the cellular function is maintained.
When nodular hyperplasia progresses to the stage of detrimented glandular function, citrate metabolism and AC activity are broken up of their balance and invites impairment in TCA cycle metabolism end accumulation of citrate occurs.
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