Two mouse babesioses, lethal
Babesia rodhaini and non-lethal
Babesia microti infections, were examined to determine if damage to kidneys and liver is correlated with the prognosis of these infections. All
B. rodhaini-infected mice died after a sudden increase of parasitemia, severe hemolysis, and excretion of reddish hemoglobinuria. All
B. microti-infected mice survived after a temporary moderate increase of parasitemia, moderate hemolysis, and execretion of greenish urine.
B. rodhaini-infected mice showed immune complex-induced mesangiopathic glomerulonephropathy, moderate renal tubular necrosis, and extensive liver necrosis. In the glomerulonephropathy, electron microscopy showed electron-dense deposits in the mesangial matrix and along the glomerular basement membrane. Biochemical analysis of blood and urine from these mice confirmed renal damage in terms of increased BUN and of proteinuria that contained albumin and protein of more than 200kDa molecular weight, and hepatic damage in terms of an increase in serum direct bilirubin.
B. macroti-infected mice had relatively mild immune complex-induced mesangiopathic glomerulonephropathy, mild renal tubular necrosis, and focal liver necrosis. BUN and serum direct bilirubin showed no increase, and proteinuria contained no detectable proteins of more than 200kDa. These data suggest that the severity of damage in the kidneys and liver is corrected with the prognosis of the two
Babesia infections.
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