The role of T cells for the resolution of acute primary infection with
Babesia microti was investigated in the present study. BALB/c mice exhibited a peak parasitemia of approximately 40% of parasitemia and subsequently recovered naturally from their primary infection. Nude mice, however, could not resolve primary infection and developed persistent high parasitemia. Mice depleted of CD4
+ T cells with monoclonal antibody (mAb) had high parasitemia and failed to control the infection. However, depletion of CD4
+ T cells one week after infection did not affect the course of infection. Depletion of CD8
+ T cells showed no apparent effect on the course of infection. High concentration of IFN-γ was demonstrated in the culture supernatant of spleen cells from untreated and anti-CD8 mAb treated mice, but not from anti-CD4 mAb treated mice. Mice treated with anti-IFN-γ mAb showed higher peak parasitemia and remained above 10% of parasitemia until days 26 after infection. These results suggest that CD4
+ T cells play an essential role in the resolution of
B. microti acute primary infection and that IFN-γ produced by CD4
+ T cells is partially responsible for control of early stage of acute infection with
B. microti
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