Journal of Pharmaceutical Science and Technology, Japan
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
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Volume 66, Issue 5
Displaying 1-16 of 16 articles from this issue
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  • Study on the Adaptation of the Standard Formulation to the Direct Compression Method (2) ―Effect of Particle Size of Materials―
    Hironobu Kato, Yuriko Ono, Hisakazu Sunada
    2006 Volume 66 Issue 5 Pages 370-379
    Published: 2006
    Released on J-STAGE: April 13, 2019
    DOIhttps://doi.org/10.14843/jpstj.66.370
    JOURNAL FREE ACCESS
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    In this study, we investigated the effect of the particle size of powdered materials on the standard formulation for the dry method by evaluating the properties of powder blends for tableting and tablets. Acetaminophen as a model drug, lactose as a additive, microcrystalline cellulose or low-substituted hydroxypropylcellulose as a binder and magnesium stearate as a lubricant were used as the composition materials with differing particle sizes. In conclusion, the particle size of each material included in the model drug affected the properties of powder blends for tableting and tablets, and the degree of effect differed with the composition and concentrations of each component. It was also confirmed that the standard formulation for direct compression was not only of considerable practical use but also highly useful for evaluation of the characteristics of various materials.

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