Journal of Pharmaceutical Science and Technology, Japan
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
Volume 74, Issue 2
Displaying 1-18 of 18 articles from this issue
Foreword
Forum
Relay Plaza
R&D
Research Laboratory
Young Researcher
Current Topic
Introduction
Colloquium
Report
Regular Article
  • Mizuho Osawa, Kenjirou Higashi, Jun Yamashita, Kunikazu Moribe, Keiji ...
    2014 Volume 74 Issue 2 Pages 160-169
    Published: 2014
    Released on J-STAGE: April 16, 2014
    JOURNAL FREE ACCESS
    The purpose of this study is to evaluate the applicability of solid dispersions prepared with hydroxypropyl cellulose (HPC). Solid dispersions were prepared with sulindac, a poorly water-soluble drug, and HPC of three different molecular weights using a hot melt extrusion method. Physicochemical properties of the solid dispersions were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and solubility studies. Permeability of sulindac was evaluated using the Caco-2 cell monolayer model. The results obtained by PXRD, DSC, and solubility studies showed that sulindac in the extrudate of sulindac/HPC (20/80 w/w) was completely amorphized and demonstrated better solubility than the drug alone. Permeability of sulindac across Caco-2 cell monolayers remarkably increased when the drug was solid-dispersed with the lowest molecular weight form of HPC (HPC-SSL). It has been concluded that HPC-SSL can be the most effective excipient in order to improve solubility and membrane permeability.
    Download PDF (393K)
feedback
Top