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Volume 25 (1984)
- Issue 4 Pages 261-
- Issue 3 Pages 183-
- Issue 2 Pages 131-
- Issue 1 Pages 85-
Volume 25, Issue 4
Displaying 1-7 of 7 articles from this issue
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T. INOUE, E. P. CRONKITE, G. E. HVBNER, K.-H. V. WANGENHEIM, L. E. FEI ...1984 Volume 25 Issue 4 Pages 261-273
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSIn order to study radiation induced residual injury in hemopoietic stem cells the number and size of spleen colonies were compared to the incorporation of 125I-labeled iododeoxyuridine (125IUdR) in the spleen after transfusion of irradiated bone marrow cells in the lethally irradiated mouse. Bone marrow cells from non-irradiated or from mice that had been given 3, 000 rad in daily 50 rad increments 5 days per week were used 3 months after termination of irradiation. Marrow cells from donor mice given 50 rad immediately prior to the experiment were comparably used to study acute radiation effect. The splenic proliferation factor (PF) (ratio of 5th to 3rd day-125IUdR incorporation) of 7.3 ± 0.2 for the 3, 000 rad irradiated bone marrow is 44.2% of the control value (16.5 ± 0.9). Spleen colonies produced by stem cells from 3, 000 rad mice are 40-50% of the size of colonies produced by nonirradiated stem cells. An acute dose of 50 rad reduced the PF from 20.7 ± 0.9 for controls to 8.0 ± 0.7 for the irradiated bone marrow. This reduction is compatible with the reduction in size and number of the spleen colonies. The cytological appearance of spleen colonies formed from the 3, 000 rad and 50 rad irradiated bone marrow was different. The colonies produced by bone marrow from mice given 50 rad immediately before preparing the BM showed extensive karyorrhexis, so called apoptosis, not seen in the colonies produced by BM cells taken from mice 3 months after receiving 3, 000 rad in 50 rad increments 5 days per week for 12 weeks.View full abstractDownload PDF (644K) -
T. WATABE, S. UCHIDA, H. KAMADA1984 Volume 25 Issue 4 Pages 274-282
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe transfer of particulate 60Co and 137Cs in a soil-plant system was investigated. Predictive equations based on a simplified mathematical model were presented in order to estimate the transfer of those nuclides to plants. Key parameters in the equations such as leaching rate (kw), uptake rate by plants (kb) and distribution coefficient (Kd) were obtained through a case study and/or experimentally. Leaching rates of particulate 60Co and 137Cs in the litter of fallen pine needles were 5 × 10-4/d and 1 × 10-3/d, respectively. Uptake rates were 0.8 ml/g/d for 60Co and 0.7 ml/g/d for 137Cs. And the distribution coefficients in equilibrium were 45 ml/g and 850 ml/g for 60Co and 137Cs, respectively. It was recognized that the transfer of those radionuclides was much dependent on kb and Kd.View full abstractDownload PDF (355K) -
A. S. ANSARI, RASHID ALI1984 Volume 25 Issue 4 Pages 283-289
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSUltraviolet irradiation of citrulline in the presence of hydrogen peroxide formed aspartic acid, glutamic acid, glycine, α-aminobutyric acid, norvaline, arginine and two unidentified ninhydrin-reactive products. Irradiation of citrulline, both in the presence and absence of hydrogen peroxide, formed ammonia and urea. The reactions followed the first-order kinetics with increased reaction constants in the presence of hydrogen peroxide. Without UV light, hydrogen peroxide itself had no effect on citrulline.View full abstractDownload PDF (219K) -
HISAMASA JOSHIMA, MASATOSHI KASHIMA, OSAMU MATSUOKA1984 Volume 25 Issue 4 Pages 290-295
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSChanges in the osmotic fragility and the mean corpuscular diameter of erythrocytes in CF#1/Nrs male mice caused by internal irradiation with polymeric 239Pu at the dose levels of 15 μCi/kg, 10 μCi/kg and 5 μCi/kg were studied at 28 and 56 days after intravenous injection of plutonium. At 56 days after injection of plutonium, osmotic fragility curves were found to shift toward lower NaCl concentration in proportion to the amount of plutonium injected, which indicated the reduction of osmotic fragility. The size distribution curves of erythrocytes were slightly shifted toward larger size, depending on the amount of plutonium injected. Mean corpuscular diameter of erythrocytes in the highest dose group was significantly larger than that of control group. Mean corpuscular thickness of erythrocytes in plutonium injected groups was not different from that of control group. The increase in the mean corpuscular diameter-to-thickness ratio might allow the erythrocyte to accumulate a larger volume of water in a hypotonic environment before reaching the critical hemolytic volume. In the present study, it was concluded that the increased diameter-to-thickness ratio of erythrocytes could be related to the diminished osmotic fragility of erythrocytes in animals given polymeric plutonium.View full abstractDownload PDF (242K) -
HARUTSUGU YAMAURA, TAIJU MATSUZAWA1984 Volume 25 Issue 4 Pages 296-304
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe radiosensitivity was studied on the capillaries growing in the rat transparent chambers. The proliferation of the capillaries was induced by the traumatic resection of the capillary bed in the transparent chambers and evaluated by the advancing speed of the vascularization borders invading the wounded regions. The transparent chambers were irradiated with Co-60 gamma-rays at various doses. The advancing speeds of the vascularization borders of the control, 50, 100, 200, 400, 600, 800, 1000, 1200, 2000 and 4000 rad groups were 0.18, 0.17, 0.15, 0.11, 0.10, 0.10, 0.08, 0.04, 0.05, 0.02 and 0.03 mm/day, respectively. These results showed two thresholds in the radiosensitivity of the growing capillaries: one at about 100 rad and the other at about 1000 rad. This double-thresholded radiosensitivity is discussed in relation with the possible endothelial stem cells.View full abstractDownload PDF (454K) -
Combined Effects of Radiosensitizers and Radioprotectors on Cultured Mammalian Cells to Co-60 γ-RaysSHIGETOSHI ANTOKU, MASAHARU HOSHI1984 Volume 25 Issue 4 Pages 305-313
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe combined. effects of misonidazole and cysteamine on the colony-forming ability of hypoxic cultured mouse leukemic L5178Y cells showed much greater protection at low cysteamine concentrations than could be expected from the protection and sensitization by the administration of each of these drugs. Similar effects, but less protection than the case of misonidazole plus cysteamine were observed for misonidazole plus cysteine. The protective effects of glutathione and thiourea were diminished by the addition of misonidazole. Results obtained for DNA single-strand breaks were similar to those for colony-forming ability.View full abstractDownload PDF (347K) -
TAKERU MINAMISAWA, SHUNSAKU SASAKI1984 Volume 25 Issue 4 Pages 314-318
Published: December 15, 1984
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe electrocorticograms (ECoGs) of the (C57BL/6 × C3H)F1 mice irradiated at juvenile or young adult were studied when they attained the age of 24-26 months. One group of mice was irradiated 35 days post partum (35-DPP) and another 105 days (105-DPP). All the animals were irradiated with 300 R of X-rays to whole body. The ECoGs were recorded from the freely moving animals with the permanently implanted electrodes fixed over the visual cortical surface. The resulted ECoGs were divided into 3 patterns: wakefulness (W), slow wave sleep (SWS), and paradoxical sleep (PS). Six parameters of the 3 patterns were compared among the 2 irradiated groups and the non-irradiated control group. The mean SWS and PS-cycle times, and mean SWS length were significantly longer in the 35-DPP group than in the control group. Changes in the ECoGs were less profound in the 105-DPP group than those in the 35-DPP group: only a significant change due to irradiation at 105-DPP was a decrease in the ratio of the total PS time to the total sleep time (TST = total SWS time + total PS time). There was no difference in the body weight and brain weight among the 2 irradiated groups and the control group.View full abstractDownload PDF (227K)
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