巻号一覧
4 巻, 3 号
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瀬在 幸安1975 年 4 巻 3 号 p. 129
発行日: 1975/06/15
公開日: 2011/10/07
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―特にfibrin coatingと抗血栓性薬剤による表面処理について竹林 淳, 鎌谷 正博, 林 宏輔, 柳 善佑, 片上 善嗣, 中上 健, 喜瀬 一登, 十倉 寛治, 浅田 健蔵1975 年 4 巻 3 号 p. 131-139
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーTwo postulated major causes of occlusion in prostheses implanted to the venous system are thrombus formation in early stages and scar tissue contraction in late stages. In an effort to avert occlusion due to scar tissue contraction, the authors devised stainless steel mesh prostheses intended for implantation to the venous system. We implanted them to the inf rarenal inferior vena cava (IVC) of dogs, and followed up their patency for periods up to 1 year. The rate of patency was as high as 58% (7/12).
To prevent formation of thrombi in early stages, we coated the stainless steel mesh prostheses with the host dog's fibrin containing various kinds of antithrombogenic agents. These prostheses were implanted to the IVC and observed for thrombus formation for 2 hours. When heparin was used as the antithrombogenic agent, the prostheses attracted no thrombi. However, the heparin-containing fibrin coating, which was prepared by allowing heparin-containing plasma to clot with Reptilase, was easily detached from the prosthesis and tended to cause extravasation of blood on declamping. When prostaglandin E, was used, the resultant coating was stable but the wall attracted a thin blood coagulum layer.
Prostheses coated with the host dog's fibrin containing these antithrombogenic agents thus proved to be quite advantageous over untreated prostheses as far as 2 hours' observation is concerned. Studies for prolonged changes are now in progress.抄録全体を表示PDF形式でダウンロード (10920K) -
動物実験成績と文献考察近藤 厚生, 三矢 英輔, 宇佐 美進, 柳 昭博1975 年 4 巻 3 号 p. 140-144
発行日: 1975/06/15
公開日: 2011/10/07
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田島 邦好, 菅原 宏見, 石塚 玲器, 佐藤 知義, 川崎 和夫, 前川 隆, 駒井 喬, 葛西 洋一, 井上 政昭1975 年 4 巻 3 号 p. 145-150
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーIn the present experimental artificial heart study the most frequent cause of death of experimental animal is the rupture of the artificial heart which was replaced totally in the chest cavity.
Artificial heart constructed with biological materials has the same problem.
The effort has made to improve the endurance of the totally biolized artificial heart.
Two kinds of synthetic rubbers were utilized for reinforcement of tissue material.
In endurance test this improved biolized artificial heart achived 8.6×106 cyclie (two months) in continuous pumping without any rupture and deterioration of the materials. Also in vitro f uactioning test revealed good Starling regulation as seen in the artificial heart reinforced with natural rubber.抄録全体を表示PDF形式でダウンロード (4045K) -
中村 昭光, 宇賀 四郎, 佐々木 義孝, 原 智次, 橋本 勇1975 年 4 巻 3 号 p. 151-155
発行日: 1975/06/15
公開日: 2011/12/02
ジャーナル フリーRehabilitation problems in fifty-one patients with cardiac pacemakers were discussed.
Adams-Stokes attacks, observed in fourty-one cases (80.3 per cent), were completely eliminated after pacing.
Occupational rehabilitation was carried out in twelve cases (55.0 per cent). Housewives and schoolgirls completely recovered.
The rehabilitation ratio in various types of conduction and rhythm disturbances were; AV block, 50.0 per cent; sick sinus symdrome, 38.0 per cent; atrial fibrillation with bradycardia, 25.0 per cent.
The physical performance of unemployed paced patients was markedly improved in thirteen cases (65.0 per cent).
The most significant factors inhibiting the rehabilitation of paced patients were age, and unfavorable social and/or family conditions.抄録全体を表示PDF形式でダウンロード (686K) -
岡澤 孜, 熊谷 英治, 阿岸 鉄三, 太田 和夫, 杉野 信博, 三谷 直之, 藤井 能成, 木村 睦, 長尾 祥三, 塚本 宏, 丹澤 ...1975 年 4 巻 3 号 p. 157-162
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーTo remove uremic toxins, it is necessary to find out a new membrane highly permeable to middle molecules. From this points, a hollow fiber artificial kidney has been developed using polymethylmethacrylate (PMMA) membrane, which is completely new material as a dialysis membrane. The dialyzer consisting of 7000 PMMA hollow fibers has the surface area of 0.61m2.
In vitro studies were performed following to “the evaluation of hemodialyzers” prepared by NIH (DH EW Publication No. 73-109).
The performance and characteristics of the dialyzer are as follows: 1) Dialysance spectrum; NaCl 135ml/min, Urea 130ml/min, Vitamin B12 50ml/min, Inulin 40ml/min (Qs=200ml/min, QD=500ml/min) 2) Ultrafiltration rate (UFR) is 19ml/min at the transmembrane pressure of 100mmHg. 3) Dialysance and UFR is stable throughout 2 hours dialysis.抄録全体を表示PDF形式でダウンロード (4688K) -
第二報安西 信行, 岡田 忠彦, 高梨 吉則, 山田 学, 稲田 栄, 小林 博司, 原 良, 山際 憲夫, 塩練 広美1975 年 4 巻 3 号 p. 163-166
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーContamination of blood through oxygen clinically used in extracorporeal circulation was reported.
Recently, air filter was used to prevent blood contamination. We studied 30 clinical cases and experiments.
Clinical cases have not revealed any symptoms and signs. But, white blood cell count, erythrocyte sedimentation rate and duration of fever in postoperation were markedly improved, in cases when air filter was used in extracorporeal circulation.
On microscopic observaton of filter, many foreign bodies were detected.
From the adove mentioned, we concluded air filter is usefull to exclude a facter of infection through oxygen.抄録全体を表示PDF形式でダウンロード (2492K) -
国米 欣明, 阪上 賢一, 林 茂夫, 松尾 洋二, 田中 浩毅, 湯村 正仁, 三輪 恕昭, 万波 徹也, 小長 英二, 折田 薫三, 田 ...1975 年 4 巻 3 号 p. 167-170
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーWith a Mini-dialyser FA-11 that we developed, we tried to construct a disposable parallel-flow hemodialyser for the use in infants. At first we established the requirements which the hemodialyser should have for the use in the infant dialysis in the age range of 3 to 12 years old, and attempted to construct two kinds of prototypes which would satisfy these requirements. In our attempts we have found that the effective membrane area would be 6, 100cm2 and 7, 000cm2, and the blood priming volume should be 25ml and 30ml, and NaCl dialysance at the blood flow rate of 150ml/min to be 70ml/min and 80ml/min. As for the ultrafiltration rate it turns out to be most adequate at 0.8ml/hour/mmHg in every instance. For this reason we believe that our hemodialyser can be used for infants in routine hemodialysis and also in the prevention of the first dialysis syndrome in adults during the hemodialysis.抄録全体を表示PDF形式でダウンロード (2269K) -
上出 健二, 真鍋 征一, 佐藤 公彦, 浜田 勝生, 奥西 秀樹, 宮崎 重1975 年 4 巻 3 号 p. 171-174
発行日: 1975/06/15
公開日: 2011/10/07
ジャーナル フリーA method for evaluating the ultrafiltration volume (UFV) during time t (v (t)) in vivo from that in vitro of artificial kidney (AK) is proposed. In this case, followings are assumed; (1) ultrafiltration rate is proportional to effective filtration area (S) and pressure difference (ΔP) loaded on a membrane, and reciprocally proportional to viscosity of blood (η(t)), and (2)η(t) can be expressed in terms of the amount of hematocrit (H(t)) only; η (t)=aH(t)2+b.
The equation relating UFV in vivo with that in vitro under the same ultrafiltration time t can be finely expressed as;
where, t indicates time after the starting of ultrafiltration, Vb, o is total volume of blood used in vitro, suffix o indicates initial value of the experiment, and the suffix (') indicates the value of in vivo and the non-suffix the value of in vitro. From eq. (1) UFV in vivo can be estimated from the data of Ho, Ho', Vb, o and v (t) when we adopt the experimental condition of ΔP'=ΔP and S'=S.
The coincidence between the value predicted from eq. (1) and the observed value in vivo was satisfactory.抄録全体を表示PDF形式でダウンロード (459K) -
太田 和夫, 須田 昭夫, 西堀 文男, 杉野 信博1975 年 4 巻 3 号 p. 175-177
発行日: 1975/06/15
公開日: 2011/10/07
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舟久保 煕康1975 年 4 巻 3 号 p. 179-182
発行日: 1975/06/15
公開日: 2011/10/07
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高須 照夫1975 年 4 巻 3 号 p. 183-184
発行日: 1975/06/15
公開日: 2011/10/07
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出月 康夫1975 年 4 巻 3 号 p. 185-186
発行日: 1975/06/15
公開日: 2011/10/07
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工藤 武彦1975 年 4 巻 3 号 p. 187
発行日: 1975/06/15
公開日: 2011/10/07
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