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稲垣 豊, 天野 泉
1979 年 8 巻 6 号 p.
688-691
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
A temporary external A-V shunt(TE A-V shunt)was originally designed for arterial blood sampling, blood access in hemodialysis and the use of a pH microelectrode. The TE A V shunt was consisted of one connection tube and two teflon needles. The teflon needles are percutaneouly inserted into an artery and a vein. The connection tube has a raw rubber portion in the middle for the arterial blood sampling or an insertion of the pH electrode. This TEA V shunt was used in five patients. In two cases without anticoagulant, TE A-V shunt was used for three days and five days, respectively. In one case with anticoagulant, it was possible to use TE-A-V shunt for much longer periods. These findings indicate that TE-A-V shunt is useful as a temporary shunt for a short period.
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石井 淳一
1979 年 8 巻 6 号 p.
692
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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大坪 修, 内間 高夫, 堀内 孝, 土肥 健純, 稲生 綱政, 福井 清
1979 年 8 巻 6 号 p.
693-696
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
In order to evaluate the polypropylene membrane for hemofilter, we have examined the solute permeability and ultrafiltration rate.
This hemofilter, consisting of 7400 pieces of polypropylene hollow fibers, has the effective surface area of 0.9m
2.
As the result of in vitro experiments, following properties were obtained.
1) Ultrafiltration rate is about 50ml/hr/mmHg/ m
22) Sieving coefficient; Urea-N 1.00, Creatinine 1.03, BSP 1.04, Vitamin B
121.04 Furthermore, in vivo experiment, it is suggested that polypropylene membrane has fine biocompatibility and high water flux.
So it will be available for hemofilter and plasma separator.
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三村 信英
1979 年 8 巻 6 号 p.
697
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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峰島三 千男, 日比 政昭, 板垣 一郎, 酒井 清孝, 鈴木 満, 井上 政昭, 中西 光, 神谷 勝弘
1979 年 8 巻 6 号 p.
698-701
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Transfer numbers( K
c/W, D
B/W or C
L/W) were introduced in analyzing the artificial kidney system (A. K. S.) which was made up of human body and dialyzer. The transport phenomena of Uremic Toxins such as urea, creatinine, uric acid in A. K. S. were investigated by compartment model based on these transfer numbers to account for the complicating relation between human body and dialyzer with respect to solute transport.
A new concept “ Maximum Concentration in Stable Periods” (MCSP), which was dependent on body weight (W), dialysance (DB) or clearance (CL), and solute production rate(G), was revealed as a result of these considerations.
The MCSP can be calculated from both preand post- solute concentration by nomograms.
If validated, those nomograms have important implications for routine dialyzer ttlerapy.
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酒井 清孝, 松田 兼一, 日比 政昭, 峰島三 千男, 山上 征二, 岸本 武利, 東仲 宣, 鈴木 満
1979 年 8 巻 6 号 p.
702-705
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
As the conventional sieving coefficient of a menbrane is calculated by using the average concentrations of blood and filtrate in the hemofiltration system, it is not correct in a strict sense. The sieving coefficient used everywhere must be corrected to introduce a new one, which is defined as a concentration ratio of blood and filtrate anywhere in the filtration.
The biomedical transport was considered with respect to dialyzer and filtrator with highly permeable membranes. The change of theoretical clearance in HD, HF, HDF under a given set of operating conditions was investigated by the idea of biomedical transport including the behavior of solutes binding with protein and erythrocytes.
The solute transport analysis combined with pool model in human body was compared with in vitro and in vivo data in hemofiltration, and it has become apparent that the good agreement was
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―2本使用時の中間希釈に対する臨床評価―
堀内 孝, 高橋 郁夫, 山田 豊, 大坪 修, 稲生 綱政
1979 年 8 巻 6 号 p.
706-709
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
In the field of the hemofiltration therapy, it is regarded as a general clinical standard, that the filter has a constant filtrate flow rate of about 70ml/min, or higher. Up to the present, filters have not yet been put to clinical use, that satisfy this standard.
Taking the effective utilization of the filters into consideration, we have devised an inter-dilution system, which is conducting a dilution in the middle of the two filters. This system has been put into clinical use, where parallelly it has been subjected to our theoretical observations.
As a result, a 1.5 times higher rate of ultrafiltration has been obtained and 30 minites shortened in each treatment on the patient has been attained.
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―特にpost及びmid-dilution方式における比較検討―
熊野 和雄, 望月 節子, 長岡 京子, 千葉 佳子, 伊藤 とも子, 今井 了, 南部 正人, 草 刈修, 酒井 糾
1979 年 8 巻 6 号 p.
710-713
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
We usually use two hemofilters connected in series in post dilution hemofiltration, because we cannot get a comercially available high flux hemofilter at present time to obtain adequate ultrafiltrate for five or six hours of treatment. But when we perform the post dilution hemofiltration with two hemofilters, sufficient ultrafiltrate is not obtained in the second hemofilter. We also notice the marked reduction of ultrafiltrate flow rate in the second hemofilter in course of treatment time. The reasons for the reduction of ultrafilt rate flow rate in the second hemofilter are thought to the decreased blood flow and high blood vescos i ty in the second hemof i 1 ter. So, to obtain the higher ultrafiltrate flow rate in the second hemof i I ter, we have performed mid dilution hemofiltration clinically since this January, which means that the substitution fluid are injected in between the two hemof i 1 ters In this mid dilution mode, the first filter are for ost dilution mode and the second are pre dilution. The use of this mid dilution mode results in 35% increase of U FR and various molecular clearances, compared with those in post dilution hemofiltration. Mid dilution hemofiltration should be indicated for the patients who want to short the treatment time of hemofiltration and who have a heavy body weight or a high blood vescosity.
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酒井 糾
1979 年 8 巻 6 号 p.
714
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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―ローラ型拍動流ポンプの試作―
佐藤 勝彦, 土屋 喜一, 福井 康裕, 副島 健市, 本多 正知, 河村 剛史, 今井 康晴, 和田 寿郎
1979 年 8 巻 6 号 p.
715-718
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
For infants, pump output flow rate should be controlled accurately, especially in low perfusion rate and not decrease at high pulse rate. Stroke volume of an air driven pump which we developed is varied with driving conditions (pulse rate, load pressure, etc.), so that it is difficult to control pump output flow rate precisely. Considering all possible items requiring to a pump for an application to an infant, we developed a pulsatile roller pump driven by a stepping motor. Employing a microcomputer for the sequential control of revolution of the stepping motor, stroke volume is able to change intentionally and controlled accurately. Moreover the pump output flow does not decrease at high pulse rate. To confirm these advantages experimentally, pump output was examined using over flow tank system. These results were as follows;
1) Changing the pulse rate from 60 to 300 [ppm] at pre-load press. :20 [mmHg] and after load press. : 80 [mmHg], the deviation of the pump flow rate was only 3.4 [%] at 500 [mL/min] and 4.2[%] at 1000 [mL/min].
2) At pulse rate 100 [ppm] and preset flow rate 500 [mL/min], the fluctuation of the flow rate was 1.6 [%] by changing pre-load from 5 to 30 [mmHg], and 1.6 [%] by changing after load from 50 to 110 [mmHg].
The pump flow rate is able to control so accurately without any feedback system that this pulsatile roller pump is suitable for pediatric surgery.
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大堀 克己, 横山 秀雄, 岡本 史之, 千葉 廸夫, 北野 一郎, 安倍 十三夫, 田中 信行, 金子 正光, 小松 作蔵
1979 年 8 巻 6 号 p.
719-721
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Cardiopumonary perfusion with pulsatile pump was performed on 30 open heart surgeries for children. Arterial pressure during the perfusion was maintained 90-100/40-50mmHg at pump flow of 100ml/Kg/min. Pulsatile perfusion was performed with satisfactory results, but competition between the heart and pulsatile pump was observed during weaning from the pump.
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小松 作蔵
1979 年 8 巻 6 号 p.
722
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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坂部 秀文, 佐々木 義孝, 和田 行雄, 越智 真一, 嶋田 秀逸, 佐藤 伸一, 内藤 和世, 玉利 公正, 白方 秀二, 中村 昭光, ...
1979 年 8 巻 6 号 p.
723-726
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
For the purpose of performing pulsatile cardiopulmonary bypass on the animals weighing 10-20kg, a middle sized pulsatile pump is made.
This pump consists of two main parts, the blood chamber and its driving part. One end of the blood chamber consists of a Bellofram rolling diaphragm, the other end consists of inlet and outlet valves. These are hinged leaflet polyurethane valves fixed at angle of 45° against the flow axis. The driving part consists of an electric motor, three kinds of special sized cams, a steel coil spring and a connecting rod.
The beat rate is determined by the revolution rate of the electric motor, that moves the cams. Stroke volume is determined by the stroke of the Bellofram movement, which is changed by the three kinds of cams. Ejection pressure is controlled by the strength of the coil spring. Thus, the beat rate, stroke volume and ejection pressure are controlled independently during cardiopulmonary bypass.
The output of this pump can be changed from 680ml/min. to 4, 050ml/min. A sufficient maximum pressure and a sufficient pulse pressure can be obtained at the total cardiopulmonary bypass by this pump on dogs.
This pump is suitable for performing pulsatile cardiopulmonary bypass on animals weighing 10-20kg.
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―Renin-Angiotensin系の検討―
船田 隆, 大平 政人, 横井 克己, 村北 和広, 五十嵐 昭夫, 岩 喬
1979 年 8 巻 6 号 p.
727-730
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Systolic hypertension and peripheral vasoconstriction are frequently encountered in the first hours after cardiopulmonary bypass. It had been suggested that the renin-angiotensin system may be involved.
Plasma angiotensin II (A II) levels were measured by radioimmnoassay in 10 patients using pulsatile bypass and in 10 patients using non-pulsatile bypass. In both groups, plasma A II levels were normal preoperatively. In the pulsatile group plasma A II levels rose during the period of bypass to mean level of 174.8pg/ml. But, in the non-puisatile group plasma A II levels rose markedly during the period of bypass to a mean level of 269.6pg/ml.
Total peripheral resistance was greater in-the non-pulsatile group, 1768 dyne cm
-5 sec as compared to1300 dyne cm
-5 sec. in the pulsatile groups.
We have concluded that the renin-angiotensin system plays an important role in the occurrence of peripheral vasoconstriction and the introduction of pulsatile flow during bypass can reduce the rise in A II levels during bypass.
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江口 昭治
1979 年 8 巻 6 号 p.
731
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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―微小循環を中心として―
越智 真一, 佐々木 義孝, 坂部 秀文, 和田 行雄, 佐藤 伸一, 嶋田 秀逸, 内藤 和世, 玉利 公正, 白方 秀二, 中村 昭光, ...
1979 年 8 巻 6 号 p.
732-735
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Experiments were carried on 16 mongrel dogs to determine if three hours' cardiopulmonary bypass can be maintained with fluorocarbon (Fluosol DA 35%, The Green Cross Corporation) without the use of homologous blood.
Dogs were anesthetized, cannulated and perfused with Fluosol DA 35% using a pulsatile pump of our own design, driven by a steel coil spring.
Microcirculation of the greater omentum was observed with a microscope. The microcirculation was maintained well all through the three hours' perfusion, so, sludging, microthrombus, opening of A-V fistula, plasmaskimming and other unfavourable findings were not observed in the vessels of the greater omentum.
The microcirculation of the greater omentum is a model of the extra-organic microcirculation. The oxygen consumption did not deceased and the resistance of systemic blood vessels did not increased during cardiopulmonary bypass, so intra-organic microcirculation was estimated to be maintained well, too.
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小児用冷却マットの試作
古謝 景春, 国吉 真行, 当山真人 , 上里 忠興, 正 義之, 青木 利三郎, 若井 秀治, 中山 芳則, 照屋 澄
1979 年 8 巻 6 号 p.
736-739
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Myocardial protection during eatracoporeal circulation was achieved by combination of cold cardioplegia and intra pericardial cooling mat for local myocardial hypothermia effectively.
Device of pediatric type was followed after adult type.
Described here is a simplified method of continuos myocardial cooling that achieves a low septal temperature of 9°-19°C in children (less than 20Kg B.W)W
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古謝 景春
1979 年 8 巻 6 号 p.
740
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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桜井 達夫, 安斎 徹男, 家里 裕, 飯島 哲夫, 尾内 弘次, 谷口 棟一郎, 川辺 昌道, 小林 剛一, 坂内 五郎
1979 年 8 巻 6 号 p.
741-744
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Prostaglandin E
1 is said to prevent the thrombocytopenia, loss of platelet reactivity, release of platelet granule contents, which would occur during extracorporeal circulation. Therefore, we applied PGE
1 to 15 open heart surgery.
PGE
1 was added into the priming circuit and infused intravenously throughout the total bypass.
The platelet count, WBC, serum hemoglobin, β-Thromboglobulin, aggregation of platelets, fibrinogen, and hemodynamics were determined throughout the operation. Following results were obtained.
1) PGE
1 reduces platelet loss and platelet injury.
2) PGE
1 decreased rear arterial blood pressure and peripheral vascular resistance.
3) Effects of PGE
1 were disappeared immediately after bypass.
4) PGE
1 decreased the bleeding from the drainage.
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宮崎 俊明, 湯田 敏行, 下川 新二, 屋良 勲, 丸古 臣苗, 尼子 春樹, 西村 基
1979 年 8 巻 6 号 p.
745-748
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Hemoglobin (Hb) released into plasma binds firmly with haptoglobin (Hp) to form Hp-Hb complex which inhibits hemoglobin from escaping through the glomerulus.
Haptoglobin was administered as a treatment of hemolysis in the patients undergone cardiac surgery with extracorporeal circulation (ECC).In twenty one patients 4000 units of Hp were given into the cardiopulmonary bypass circuits.
In fifteen patients who had not received Hp, free serum Hb, Hb other than Hp-Hb complex, appeared at the end of ECC.
In the group treated with Hp, total serum Hp maintained higher level than total Hb. In other words, free serum Hp maintained its positive level and free serum Hb did not appeared after the administration of Hp.
Administration Hp prevented gross hemoglobinuria effectively and preserved the postoperative renal function.
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正津 晃
1979 年 8 巻 6 号 p.
749
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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今村 栄三郎, 松本 尚己, 笠置 康, 沢谷 修, 北村 信夫, 横山 正義, 和田 寿郎
1979 年 8 巻 6 号 p.
750-753
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
With use of mandrils of various sizes inserted into center of valve orifice, stent-mounted porcine aortic xenografts were fixed with glutaraldehyde. 5 valves fixed in open position and 4 valves fixed in closed position were studied using our pulse-duplicator.
Results showed that the closed type valves opened in sequence at low flow state, while in contrast the open type valves offered more physiologic valve function characterized by symmetric cusp opening independent of flow conditions. Minimal turbulence and instantaneous cusp movement on closure seemed to contribute to imrpoved fatigue durability of the open bioprosthesis.
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守永 典彦, 高木 博己, 星野 芳弘, 小島 逸也, 西村 祥三, 大石 喜六, 古賀 道弘, 森松 稔
1979 年 8 巻 6 号 p.
754-757
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
It is well known that glutaraldehyhe treated porcine xenograft has been responsible for improvement in long term clinical results.
107 glutaraldehyde treated porcine xenograft, namely 30 Hancock valves and 77 Carpentier valves ware used for 104 patients operated upon between october, 1974 and october 1979 at Kurume University, besed upon our clinical experience of original 4% formaldehyde treated homologous valve implantations to congenital heart disease.
Ninety patients had acquired valvular disease (AHD), and fourteen patients had congenital heart malformation (CHD). Hospital mortality rate of AHD and CHD were 8.9 percent and 50 percent, respectively. 2.2 percent of late death was noted on AHD group. Cause of death were heart insufficiency, , renel failure and bleading. Reoperations were performed upon 2 cases of AHD group because of perivalvular leakage. There were no evidence of valve related complications, snch as thrombembolism and mitral regurgitations due to the atrophy of leaflet or cusp perforation, even though varions complications were reported. However still delicate surgery and post operative care are required.
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江郷 洋一, 川副 浩平, 林 研二, 藤井 尚文, 小柳 仁, 藤田 毅, 太田 光重, 小塚 隆弘, 梅津 光生, 曲直部 寿夫
1979 年 8 巻 6 号 p.
758-761
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
A new modified orifice xenograft (Hancock·Mo) has been designed with the muscular leaflet of the porcine valve excised and replaced with non-muscular leaflet of a second valve.
The Hancock·Mo has been implanted 28 patients ranging in age from 17 to 59 years. (mean, 44.3 years) A 21mm prosthesis was implanted in 4 patients, 23mm prosthesis in 13 patients, and 25mm prosthesis in 11 patients. Two of them died, one was due to renal failure, the other one was due to pulmonary bleeding. There have been no lale deaths, no valve dysfunction, and no thromboemboli. Mean transvalvular pressure gradient was found to vary widely, averaged 19.5mmHg for 21mm prosthesis, 23.4mmHg for 23mm prosthesis, 24.2mmHg for 25mm prosthesis.
Calculated orifice area averaged 1.27cm
2 for 21mm, 1.33cm
2 for 23mm, 144cm
2 for 25mm prosthesis. So calculated orifice area of Hancock·Mo showes less widely than that of the Björk-Shiley valve or lonescu-Shiley valve, however, showes improvement over the standard model 242 as the compostite valve, especially small sizes. The Hancock·Mo xenograft has the advantage for the patient with a small aortic annulus.
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大石 喜六
1979 年 8 巻 6 号 p.
762
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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筒井 達夫, 北村 信夫, 今村 栄三郎, 和田 寿郎, 松本 尚己, 津田 裕一, 土屋 喜一
1979 年 8 巻 6 号 p.
763-766
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
This study was made as the basic research for the developement of the new tri-leaflet valve prosthesis in aortic position.
On the basis of the analysis of the opening characteristics of normal aortic valve, non-stented tri-leaflet valve prosthesis was produced with polyurethan.
The hydrodynamic properties were compared between non-stented valve and other 3 artificial valves. Nonstented tri-leaflet valve was superior to Björk-Shiley, S. J. M. and Hancock valves in forward flow, opening transvalvular pressure gradient and pump load during early 1/5 systolic time.
From the result of this study, it became evident that non-stented trileaflet valve had more advantageous hydrodynamic properties than other artificial valves.
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井上 隆夫, 佐々木 進次郎, 武内 純夫, 高橋 〓二郎, 麻田 邦夫, 岸田 尚夫, 志熊 粛, 西本 孝, 柿本 祥太郎, 武内 敦郎
1979 年 8 巻 6 号 p.
767-770
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Thirty-five Lillehei-Kaster pivoting valves were used for 17 aortic and 18 mitral valve replacements during the period from June, 1971 to October, 1979. The patients ranged in age from 14 to 54 with an average of 39.3 years old. The operative mortarity was 20%, but there was no late death. EVA was mesured during operation in 14 and late operatively in 8 cases. The pressure gradient across the valve during operation was minimal: 3.3-27mmHg in AVR and 2.5-8.0mmHg in MVR. The %EVA was 55-98% in AVR and 61-65% in MVR. The pressure gradient measured late postoperatively in MVR was 2.8-7.0mmHg and the %EVA was 93-111%. The incidence of thromboembolism was 7.7% in AVR and 9.7% in MVR. The majority of the survivals are doing well (NYHA I and II).
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小机 敏昭, 久米 弘洋, 松井 道彦, 堀越 茂樹, 鈴木 茂, 丸山 浩一, 杉田 洋一, 佐々木 達海, 益子 健男, 新井 達太
1979 年 8 巻 6 号 p.
771-774
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
The valve replacement with St. Jude Medical cardiac valve was undertaken in 20 patients between July, 1978 and October, 1979 (AVR 8, MVR 7, TVR 1, AVR+MVR 2, MVR+TVR 1, AVR+MVR+TVR 1). One patient in AVR died on fifth postoperative day from pulmonary edema, and three patients in MVR died in the hospital from low cardiac output syndrome (two patients) and arrhythmia (one patient). In the eight patients who had postoperative cardiac catheterization, the mean resting cardiac output was 5.48L/min, LV/Ao pressure gradient in the AVR group was not recognized and transvalvar gradient in the MVR was 7.5±4.50mmHg. In the single mitral valve replacement, intraoperative mean left atrial pressure was 24.7±4.21mmHg, and mean pulmonary capillary wedge pressure was 15.5±4.50mmHg in the postoperative cardiac catheterization.
In conclusion, the St. Jude Medical cardiac valve was hemodynamically excellent, but in the single MVR our result was not so good.
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新井 達太
1979 年 8 巻 6 号 p.
775
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
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石原 智嘉, 宮田 義弥, 大宮 孝, 玉木 修治, 村瀬 允也, 小林 淳剛, 土岡 弘通, 弥政 洋太郎
1979 年 8 巻 6 号 p.
776-779
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Since 1965, 505 cardiac pacemakers have been implanted in 250 patients with the total surgical intervention of 540 times. During this period of time, infection in conjunction with pacemaker implantation occurred in 10 patients on 11 occasions with an incidence of 2.0%, and 21 surgical interventions were necessary to control the infection.
The infection became manifest 1 to 11 months (average 4.5) after surgery in 7 occasions, while a skin ulceration preceded infection, which became manifest 11 to 25 months (average 17.2) after surgery, in 4 occasions.
In order to control the infection, the infected pacemaker was replaced with a new one to another position in 4 occasions. In 3 occasions, surgery was carried out in such a manner that the proximal portion of the lead was replaced with a lead extender and connected to a new generator, which was implanted in a new subcutaneous pocket. In the remaining 4 cases, polysurgery was necessary. In one case, 7 surgical interventions were carried out during the period of 18 months. In one case, endocarditis developed due to infection of a fragment of the lead left in the right atrial cavity. In other case, a major surgery was necessary to remove an endocardial lead.
With a tined endocardial lead of the present use, some technical difficulties to control infection, once occurs, may be encountered because of impossibility of its removal.
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村瀬 允也, 土岡 弘通, 阿部 稔雄, 清水 健, 鷲津 卓弥, 田中 稔, 小林 淳剛, 野垣 英逸, 椙山 直敏, 竹内 栄二, 鬼頭 ...
1979 年 8 巻 6 号 p.
780-783
発行日: 1979/12/15
公開日: 2011/10/07
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In 221 cases of permanently paced for bradyarhythmia, the long term prognosis was studied.
Twenty-eight patients (12.7%) died during the follow-up period of 6 months to 12 years (mean 4 years). The survival rate at 5 years was 81% and 75% at 10 years according to actuarial analysis. In the AV block group it was 82% at 10 years and in the sick sinus syndrome 78% at 8 years. In the group with myocardial damage such as previous myocardial infarction or valvular disease, it was so low as to be 30% at 10 years. According to their physical activity, 66% was in class I or II of NYHA.
Sixty-eight percent of patients receive drugs for cardiovascular system.
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土岡 弘通
1979 年 8 巻 6 号 p.
784
発行日: 1979/12/15
公開日: 2011/10/07
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兼古 悟, 佐々木 孝, 杉木 健司, 安倍 十三夫, 田中 信行, 小松 作蔵
1979 年 8 巻 6 号 p.
785-788
発行日: 1979/12/15
公開日: 2011/10/07
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In the management of the patient it is very important to considre the appropriate time of pacemaker (PM) replacement. The impedance and the threshold have a strong influence on the service life of PM. We conducted a detailed investigation on following points, current output in accordance with impedance changes and the voltage of the battery accompanied by the changes of pulse width, pulse rate and battery wearout. If the resistance of the load increases, the current output decreases. Assuming a load less than 500 ohms, the span of life should be decreased. If the voltage of the battery decreases, the current output, and pulse rate decreasem but pulse width. increases autmatically.
Conclusively, it is proposed the the pulse rate, pulse width and current output of PM with the wearout of the battery should be laveled on the individually for safety of pacing.
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進藤 剛毅, 高山 鉄郎, 清水 進, 古瀬 彰, 水野 明, 三枝 正裕
1979 年 8 巻 6 号 p.
789-792
発行日: 1979/12/15
公開日: 2011/10/07
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Clinical studies of the threshold of cardiac stimulation were carried out. One hundred two electrodes (Medtronic and Cordis) were followed up move than 12 months up to 126 months after initial implantation. The studies revealed that,
1), Voltage and current thresholds increase chronically as a responsiveness of myocardial tissue around electrode.
2), Electrode surface areas had influence upon voltage threshold among Cordis leds.
3), Bipolar vs. unipolar electrode did not effect upon the current threshold.
4), Energy ratio was large (more than 50:1) at the initial measurement and decreased very fast down to 20:1 within 10 months especially in electrodes with small surface area.
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池田 晃治
1979 年 8 巻 6 号 p.
793
発行日: 1979/12/15
公開日: 2011/10/07
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―閉じたループをもつ人工臓器の開発について―
菊地 真, 山田 明夫, 町山 悦子, 壁井 信之, 桜井 靖久
1979 年 8 巻 6 号 p.
794-796
発行日: 1979/12/15
公開日: 2011/10/07
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―放射線を利用したカプセル化技術の検討―
嘉悦 勲, 熊倉 稔, 吉田 勝, 山田 明夫, 桜井 靖久
1979 年 8 巻 6 号 p.
797-799
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
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Composite materials consisting of vinyl monomers and biofunctional components were developed by means of radiation polymerization. These materials are characteristic for stable and high biological activities, easy shaping into various forms and sizes, broad selectivity of polymer qualities and easy control of fixation and release functions of biocomponents. One of the important application is the direct chemotherapeutic treatment of cancer by the capsules including anticancer. It was found that single or multi-component anticancers were released at the desired rate for long period from capsule and effective cure was possible without side effects.
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岡野 光夫, 片岡 一則, 赤池 敏宏, 桜井 靖久, 島田 昌, 鵜木 正夫, 宮原 将, 篠原 功
1979 年 8 巻 6 号 p.
800-803
発行日: 1979/12/15
公開日: 2011/10/07
ジャーナル
フリー
Amphiphilicity of polymer surfaces play an important role in biocompatibility. However, the conception of the balance between hydrophilicity and hydrophobicity remained to be obscure owing to the lack of systematic research on biomedical application of amphiphilic polymers. We have synthesized 2-hydroxyethyl methacrylate-styrene block copolymers to control the amphiphilicity in the level of assembled order of macromolecules. Interaction of platelet with the block copolymer surface precoated with or without blood proteins was investigated by the microsphere column beads method to clarify the mechanism of the antithrombogenic properties of microphase separated structure. Block copolymer surface exhibited antithrombogenecity due to the blocking platelet adhesion and aggregation. It was considered that the organized structure of adsorbed proteins on the surface with microphase separated structure controlled capping formation of platelet owing to affecting the dynamic motion of platelet membrane.
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片岡 一則, 岡野 光夫, 赤池 敏宏, 桜井 靖久, 前田 瑞夫, 西村 隆雄, 似鳥 嘉昭, 鶴田 禎二, 島田 昌, 篠原 功
1979 年 8 巻 6 号 p.
804-807
発行日: 1979/12/15
公開日: 2011/10/07
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With the development of cell transfusion therapy and hybrid-type artificial organs, needs for new materials used in cell-separation and cell-culture are amply realized. In this respect, we investigated the interaction of synthetic polymer membranes with blood cells, involved erythrocytes, leukocytes, lymphocytes, and platelets, by using “column method”. Following results are obtained: (1) Membrane properties of three kinds of blood cells are different from one another, and so, separation based on adhesion might be possible. (2) Both adhesion and metamorphosis of platelets can be controlled on the synthetic membrane having weakly cationic domains (SAx). (3) Cell adhesion is significantly affected by species, distribution, conformation, and orientation of proteins adsorbed on synthetic membranes.
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―グルタールアルデヒド架橋によるコラーゲン合成高分子の再検討―
松延 政一, 清水 慶彦, 宮本 好博, 加藤 弘文, 渡辺 智, 和田 洋已, 寺松 孝, 日野 常棯
1979 年 8 巻 6 号 p.
808-811
発行日: 1979/12/15
公開日: 2011/10/07
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To screen the tissue affinity of various biomaterials, the growth rate of fibroblasts upon them was broadly used. But from the point of histological data of
in vivo, the macrophage and fibroblast co-cultured system seemed to be more reasonable to evaluate them. In this study, the affinity of collagen coated materials were evaluated using these two systems. Among various copolymeriz.ation of collagen, the treatment of low concentration of glutaraldehyde was most effective.
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The Current Status of Research Activities in Taiwan
C. J. LEE
1979 年 8 巻 6 号 p.
812-814
発行日: 1979/12/15
公開日: 2011/10/07
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戸川 達男
1979 年 8 巻 6 号 p.
815
発行日: 1979/12/15
公開日: 2011/10/07
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