巻号一覧
8 巻, 5 号
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寺松 孝1979 年 8 巻 5 号 p. 489
発行日: 1979/10/15
公開日: 2011/10/07
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その研究の現状岩下 雄二1979 年 8 巻 5 号 p. 491-495
発行日: 1979/10/15
公開日: 2011/10/07
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藤 正巖1979 年 8 巻 5 号 p. 496-498
発行日: 1979/10/15
公開日: 2011/10/07
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小島 洋彦, E. C. LAYNE, L. J. THOMAS, D. F. SAYLER, S. P. BESSMAN1979 年 8 巻 5 号 p. 499-504
発行日: 1979/10/15
公開日: 2011/10/07
ジャーナル フリーA totally implantable artificial β-cell has been developed at the University of Southern California, School of Medicine (Professor S. P. Bessman). It consists of the glucose sensor which senses the tissue glucose, and the micropump and the computer-amplifier system which delivers insulin in appropriate amounts responding to the tissue glucose concentration. The self-powered sensor has two galvanic oxygen electrodes in a plastic housing about the size of a nickel. A tetron cloth matrix over one electrode contains glucose oxidase which consumes oxygen according to the glucose concentration existing in the tissue in relation to the other (reference) electrode. The micropump which has a piezoelectric disk bender and a solenoid valve is able to deliver a very small amount (1-8μl) of insulin at 40-180mmHg per strokecycle (pulse train). The frequency of the pump cycle is controlled by the differential output of the sensor. It is previously adjusted at the slow rate of about 1 cycle/2.5 min responding below 100mg% of the tissue glucose and at the fast rate of about 1 cycle/30sec responding above 100mg% glucose. The artificial β-cell i. e., the micropump, sensor, insulin reservoir, and batteries are implanted subcutaneously and insulin is delivered intraperitoneally in dogs for five days. The successful implantation and subsequent control of the blood sugar in the diabetic dogs is attained.抄録全体を表示PDF形式でダウンロード (2708K) -
稲生 綱政, 大坪 修, 太田 和夫, 阿岸 鉄三, 中川 成之輔, 中林 宣男1979 年 8 巻 5 号 p. 505-509
発行日: 1979/10/15
公開日: 2011/10/07
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垣内 孟, 田端 義久, 馬渕 非砂夫, 村尾 之義, 青木 正, 中橋 弥光1979 年 8 巻 5 号 p. 510-514
発行日: 1979/10/15
公開日: 2011/10/07
ジャーナル フリーCogestive heart failure and other cardiovascular disorders secondary to associated overhydration, hypertension, electrolyte imbalance and others develop in patients with renal failure undergoing hemodialysis (HD). According to their vascular management two periods are classified—the induction and the chronic maintenance.
This report suggests two basic different considerations in the control of fatal arrhythmias developed Adams-Stokes attack.
The first case was a patient of the induction period whose ECG indicated sinus pause and slow A-V junctional rhythm with a short-run of ventricular ectopics who developed the attack mentioned above. The coexistence of hyperkalemia, hypocalcemia and acidosis was thought to be the cause of this abnormal ECG. The combined treatment with a temporary pacemaker (TPM) and HD was performed. On the fourth day serum K, Ca, and pH were normalized in spite of minimal reduction of body weight, and fortunately sinus rhythm was definitely restored. Hence, the improvements of electrolyte derangements and blood pH by HD with a TPM must be more important than the reduction of volume overload.
The second case was a patient of the chronic maintenance period with paradoxycal bradycardia and frequent hypotensions during HD and ECUM, and he, too, finally developed the attack and shock even though a small amount of blood was removed into the circuit. The combined treatment with a TPM and peritoneal dialysis (PD) was performed for 11 days. Approximately 5kg of body weight was reduced without remarkable changes in chemicals. Hence, efforts should be made under a TPM to reach as dry weight as possible. PD might be more efficient to paradoxycal bradycardia than HD.抄録全体を表示PDF形式でダウンロード (4104K) -
垣内 孟, 田端 義久, 馬渕 非砂夫, 村尾 之義, 青木 正, 中橋 弥光1979 年 8 巻 5 号 p. 515-521
発行日: 1979/10/15
公開日: 2011/10/07
ジャーナル フリーHemofiltration (HF)—A new method for the treatment of chronic renal failure has been introduced earlier. It has also been reported that less hypotensive episodes and disequilibrium syndromes develop during this procedure in comparison with the conventional hemodialysis (HD).
This report compares the following hemodynamic parameters, to elucidate possible different hemodynamic attitudes, such as C. O., C. I., TPRI, BP and HR with the two procedures mentioned above. We finally obtained the following conclusions. 1) C. O. change during HF is classified into two different types of C. O. patterns, in accordance with patient's volume loading, such as Type A (Y=aX2+bX+c, a<0, b>0) and Type B (Y=aX+b, a<0) as we previously reported the same patterns during HD. 2) PA change during two procedures decreases linearly in spite of different C. O, patterns, which could be explained by a reduction in central blood volume and a slight augmentation in blood pH. 3) Hemodynamic parameters during HF are definitely more stable than those during HD. Progressive increase of TPRI during HF is especially important to prevent from hypotension. 4) The point of Dmax could be reached earlier than that of Fmax by a decreases of C. I. 5) Each unfavorable limb passing though Dmax and Fmax during HF and HD leads to hypotensive episode, and shock could be developed at the time of approximate values of 1.7l/min/m2 in C. I. and 1, 700 dyn· sec·cm-5/m2 in TPRI.抄録全体を表示PDF形式でダウンロード (825K) -
松尾 理, 西本 憲一, 丸岡 伸比古, 宮崎 洋1979 年 8 巻 5 号 p. 522-525
発行日: 1979/10/15
公開日: 2011/10/07
ジャーナル フリーSince dextran sulphate (DS) has enhancing action on fibrinolysis and suppressing action on platelets and coagulation, the effect of DS administration on the potency of vascular graft was investigated. The knitted dacron graft (13mm length, 6mm ID) was implanted into the abdominal aorta. DS (3g) was administered intravenously during the first 4 postoperative days and parentally following 9 days. The dogs were autopsied at 14 th postoperative day and potency of the implanted graft was measured. In the DS administered dog, fibrinolytic activity enhanced and coagulation activity was suppressed. On the other hand, in the control dog, fibrinolytic activity was not enhanced and coagulation activity was enhanced. However, on the potency of vascular graft, there was no significant difference between DS administered group and control group. This is probably due to early autopsy after the vascular graft implantation.抄録全体を表示PDF形式でダウンロード (496K) -
三田村 好矩1979 年 8 巻 5 号 p. 526-527
発行日: 1979/10/15
公開日: 2011/10/07
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1979 年 8 巻 5 号 p. 528-530
発行日: 1979/10/15
公開日: 2011/10/07
ジャーナル フリーPDF形式でダウンロード (456K)
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