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Volume 34 (1979)
- Issue 6 Pages 779-
- Issue 5 Pages 713-
- Issue 4 Pages 631-
- Issue 3 Pages 477-
- Issue 2 Pages 357-
- Issue 1 Pages 31-
Volume 34, Issue 4
Displaying 1-6 of 6 articles from this issue
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Morihiro MATSUDA1979 Volume 34 Issue 4 Pages 631-665
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSDownload PDF (11626K) -
Kaneo NOGAKI1979 Volume 34 Issue 4 Pages 667-676
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSThis report deals with the effects of cyclic nucleotide derivatives and immunostimulators on phagocytosis of Staphylococcus aureus and other opportunistic pathogens by polymorphonuclear leucocytes and macrophages.
1) Mice infected intraperitoneally with diffuse-type staphylococci showed an increase fatality when pretreated with 10mg/mouse of DBcAMP and 20ng/mouse of cholera toxin, but a slight decrease when pretreated with 0.25mg/mouse of 8-Br-cGMP.
2) When mice were pretreated intraperitoneally with 1KE of OK-432, an immunostimulant prepared from the Su strain of streptococci, none or less than 20% of them died from infection with Smith diffuse staphylococci. Pretreatment of mice with 1KE of OK-432 was more effective than pretreatment with 10 or 100μg of the heat-killed Su strain of streptococci, which corresponded to 0.1 or 1.0KE of OK-432, respectively, or with 100μg of zymosan particles.
3) Pretreatment by intravenous injection with OK-432 protected mice from intraperitoneal challenge not only with Staphylococcus aureus but also with some other opportunistic pathogens, such as Serratia marcescens TO-5, Pseudomonas aeruginosa and Candida albicans.
4) Intravenous injection with 1KE of OK-432 for 7 days prevented mice from decreasing in resistance to intraperitoneal infection with Smith diffuse staphylococci. This resistance had been developed in these mice by intraperitoneal injection with 10μg of water-soluble dexamethasone phosphate ester for 7 successive days.
5) Macrophages derived from OK-432 treated rabbits had stronger phagocytic activity in vitro than those derived from untreated rabbits.View full abstractDownload PDF (3080K) -
Investigation with cells of Group F streptococcal reference strain O'Mahoney (Colindale)Yasuhiko NAKAYAMA, Shizue MAEKAWA1979 Volume 34 Issue 4 Pages 677-684
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSBy the aid of Ouchterlony's agar diffusion and immunoelectrophoretic techniques, it was found that cells of Group F streptococcal reference strain “O'Mahoney (Colindale)” contained at least three protein antigens having specificities different serologically from one another.
The three protein antigens should be considered as R-protein antigens on the basis of the following characteristics.
(1) They were resistant to trypsin-digestion, by which streptococcal M-protein antigen will be affected. (2) They were also resistant to heating at 100C for 15min at pH 2.0, by which streptococcal T-protein antigen will be affected. (3) They were inactivated by pepsin-digestion, by which T-protein antigen will not be affected.
It should be considered that one of the three protein antigens corresponds partially to 28R-protein antigen which was initially reported by Lancefield in 1943, since the precipitation line between that protein antigen and anti-28R-protein serum showed a remarkable spur formation on agar gel plate. From the results of Ouchterlony's agar diffusion test, it is inferred that the other two protein antigens contained in the definite strain may be specific antigens entirely different from any of the protein antigens, i.e., 28R, M, T and Group B Ibc.View full abstractDownload PDF (3649K) -
Masa-aki HAYAMI1979 Volume 34 Issue 4 Pages 685-692
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSLipid compositions in the stable L-form and the autoplast (protoplast made by autolysis) derived from Staphylococcus aureus 209P were studied in correlation to an adaptational change of the plasma membrane against the loss of cell wall.
Cardiolipin content comprised over 50% of the total phospholipids (parent, 10%) both in L-form and autoplast, while phosphatidylglyceride, the precursor of cardiolipin, lowered the content to 30% (parent, 76%). The increase of cardiolipin was resulted clearly from the removal of cell wall. Cholesterol was found in stable L-form at the amount of 0.75% of total lipids. The synsthesis activity of cholesterol seemed to be expressed by the L-form transformation.
The role of cardiolipin and cholesterol in a wall lacking cell was discussed in the light of adaptational changes in lipid composition of plasma membrane.View full abstractDownload PDF (6074K) -
Hayashi AWANO1979 Volume 34 Issue 4 Pages 693-695
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSDownload PDF (1802K) -
1979 Volume 34 Issue 4 Pages 697
Published: July 25, 1979
Released on J-STAGE: February 19, 2009
JOURNAL FREE ACCESSDownload PDF (33K)
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