Delayed-type hypersensitivity of
Candida albicans (
C. albicans) or
Sporothrix schenkii (
S. schenkii) was transferred specifically to nonimmune mice by intraperitoneal injection of dialysate of the spleen cell extract (Transfer Factor; TF) prepared from the immune mice. The mice treated with TF displayed significantly thickened footpads in the footpad swelling test. Morever, the
Candida TF-treated mice survived the infection with a lethal dose of
C. albicans. Fewer cells of
C. albicans were recovered from the lungs and kidneys of the
Candida TF-treated mice than from those of the mice treated with the dialysate of the spleen cells from nonimmune mice.
View full abstract