Preah Vihear in Cambodia is typically an isolated region that has been neglected for many decades. In 2008, when Preah Vihear was listed as World Heritage Site, the Cambodian government finally started to pay attention to this remote region. One of the most important issues is how Preah Vihear could be an economic and eco-cultural motor for the development in one of the poorest regions in the country. Preah Vihear can be an engine for the development of the region, if once its potentials of cultural heritage combine with its natural resources. This paper indicates that Preah Vihear and its region has various heritage values and regional cultural values, and its resources are able to generate development. These could lead to the road of sustainability, if once all the criteria for economic growth works well and the conditions for social progress are fulfilled. In that perspective, Preah Vihear must have a chance to achieve its final goal and reduce poverty gap by sustainable development.