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Volume 3, Issue 3
Displaying 1-8 of 8 articles from this issue
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Junichi Yata1980 Volume 3 Issue 3 Pages 113-120
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSDownload PDF (474K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1980 Volume 3 Issue 3 Pages 121-132
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESS -
Multiple skin tests of benign diseasesKon Min Chen, Kenji Ogino, Hiroyuki Soga, Shin Matsumoto, Tetsuro Okaz ...1980 Volume 3 Issue 3 Pages 133-139
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSTwo hundred and twenty two patients with various benign diseases were tested with 4 types of delayed hypersensitive skin tests (PPD, PHA, Candida and SK-SD) and evaluated their nutritional status by hemoglobin, lymphocyte, serum albumin and ratio of weight to height before operation. The skin test index was calculated by using an equation: STI=log DT+log DC+log DP+log DS-0.4/4 (DT, DC, DP, DS: mean diameter of PPD, PHA, Candida and SK-SD). The STI was compared with nutritional parameters using linear regression.
The following results were obtained:
1) Subnormal response, namely, STI smaller than 1.0, existed in 42% of heart diseases, 23% with digestive benign diseases and 12.5% with other benign diseases.
2) STI was well related with hemoglobin and albumin in the heart diseases and digestivebenign diseases.
3) STI was significantly depressed in patients with NYHA classificationIII-IV.View full abstractDownload PDF (304K) -
Norio Shimizu, Hiroshi Yoshioka, Akio Izumi, Ryuichi Hamazoe, Yukio Os ...1980 Volume 3 Issue 3 Pages 140-145
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSIn cancer patients, surgical intervention has been reported to depress cellular immune competence in the early postoperative phase, thereby enhancing the proliferation of cancer cells scattered during surgery or the growth of residual cancer.
Immunopotentiators such as PSK, Levamisole and Lentinan were administered to gastric cancer patients one or two weeks prior to surgery to prevent depression of postoperative
cellular immunity.
PSK was administered 3g/day perorally for seven consecutive days one week before surgery, Levamisole was also administered 150 mg/day perorally for three consecutive days one or two weeks before surgery and Lentinan was injected intravenously 0.5, 1 or 5mg twice a week one or two weeks before surgery.
Numbers of leucocytes and lymphocytes were counted before and one week after immunopotentiator administration. Phytohemagglutinin (PHA) and Purified Protein Derivative (PPD) skin tests and PHA-induced lymphocyte transformation rate were examined before and one or two weeks after immunopotentiator treatment and one or two weeks after surgery.
These immunological parameters showed preoperative immunopotentiator administration could prevent the depression of cellular immunity in the postoperative early phase.View full abstractDownload PDF (313K) -
Toshio Arao, Kazuo Kura1980 Volume 3 Issue 3 Pages 146-151
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSLevels of circulating immune complexes in the serum of patients with connective tissue diseases were measured by the 125I-protein A-PEG procedure. These included 21 patients with systemic lupus erythematosus (SLE), 20 rheumatic arthritis (RA), 11 sicca syndrome (SS), 9 progressive systemic scherosis (PSS), 9 mixed connective tissue diseases (MCTD) and 10 healthy individuals. The groups of connective tissue diseases except for SS had increased levels of immune complexes in serum compared to a group of healthy individuals. In particular, patients with SLE and RA were high levels of immune complexes. No correlation was found between the levels of circulating immune complexes and serum complement (CH50, C3 and C4). Also, there was no correlation with the titers of IgM-rheumatoid factor in the sera of patients with seropositive RA.
125I-protein A-PEG procedure is a sensitive, simple and not complement dependent.View full abstractDownload PDF (266K) -
Keigo Ono, Hirohide Ino, Jun Akimoto, Shigeru Sho, Takeo Kuroyanagi1980 Volume 3 Issue 3 Pages 152-158
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSA 34 year old male was admitted to the hospital with polydipsia, polyuria, severe bone pain and deformity of thorax. Twelve years previously, glycosuria and proteinuria had been established.
He had a severe Bence-Jones proteinuria. The presence of κ-type light chain in serum and urine was demonstrated by tne immunoelectrophoreses. Residual immunoglobulins were markidly decreased. However, the percentage of plasma cells in the bone marrow was less than 10% and few atypical plasma cells were found. Therefore, it seems likely that he has not yet developed multiple myeloma but has been in the premyelomatic state.
He had also the Fanconi's syndrome, the distal renal tubular acidosis and the renal diabetes inspidus.
Therefore, the diagnosis of the light chain (κ) disease associated with the combined light chain nephropathy was made. Until recently only 8 cases of the combined light chain nephropathy (Smithline, 1976) have been reported in literatures.View full abstractDownload PDF (2428K) -
Hajime Kawamura, Akira Takeda, Nobuyuki Gonda, Morito Sumiya, Kazuo Os ...1980 Volume 3 Issue 3 Pages 159-165
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSDysphagia developed in a 39-year-old woman with 10 years' history of recurrent fever, arthralgia and erythema, nasopharyngeal ulcer, otitis media and migratory reticulonodular pulmonary shadows.
A localized esophageal stenosis at the level of 7th cervical vertebra was demonstrated by esophagogram. Biopsies of the erythema and nasopharyngeal lesion revealed necrotic arteriolitis. Urinalysis on admission was normal. The diagnosis of Wegener's granulomatosis, limited form, was made. Eight months after admission, proteinuria and granular cast appeared and serum creatinine level was increased. She was treated with high dosis of cyclophosphamide and the level of serum creatinine returned to normal.
Esophageal involvement in Wegener's granulomatosis is rare. There is only one case report in the literature, in which there was circumferential erosion in the esophagus, the histological examination of which revealed vasculitis. We thought the esophageal stenosis in this case is most probably due to Wegener's granulomatosis itself, because dysphagia appeared when Wegener's granulomatosis was active and there was no other apparent cause of esophageal stenosis such as ingestion of corrosive substance.View full abstractDownload PDF (3342K) -
Nobuyuki Gonda, Shogo Kano, Morito Sumiya1980 Volume 3 Issue 3 Pages 166-171
Published: July 30, 1980
Released on J-STAGE: January 22, 2009
JOURNAL FREE ACCESSThe virus plaque assay for enumerating activated T lymphocytes were applied to studies of human lymphocytes in young and older subjects.
The production of virus plaque-forming cells (V-PFC) in con A-stimulated and unstimulated cultures was reproducible in five repeated experiments, whereas that in PHA-stimulated cultures was highly variable. Since the stimulation of 3H-thymidine incorporation by PHA in the parallel cultures was reproducible, the aggregation of PHA-stimulated lymphocytes may account for the variability in the number of V-PFC. The treatment with carbonyl iron and magnet to remove monocytes did not affect the production of V-PFC. When the virus plaque assay was applied to the study of mitogen responses of peripheral blood lymphocytes in 8 old subjects (betweeh the ages of 68 and 87) and in young controls (under the age of 38), con A-and PHA-responsive V-PFC were significantly reduced (p<0.01) in old subjects as compared with those in young controls. Similarly, the level of mitogen-induced 3H-thymidine incorporation was significantly lower (p<0.01) in old subjects than that in young controls. These findings may indicate that the number and the proliferative capacity of mitogen responsive T cells are reduced in old subjects.View full abstractDownload PDF (315K)
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