Japanese Journal of Clinical Immunology

Japanese Journal of Clinical Immunology

Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300

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Volume 36, Issue 5

The 41st Annual Meeting of the Japan Society for Clinical Immunology

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[title in Japanese]

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2013Volume 36Issue 5 Pages 404a
Published: 2013
Released on J-STAGE: October 31, 2013

DOIhttps://doi.org/10.2177/jsci.36.404a

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2013Volume 36Issue 5 Pages 404b
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DOIhttps://doi.org/10.2177/jsci.36.404b

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2013Volume 36Issue 5 Pages 405a
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DOIhttps://doi.org/10.2177/jsci.36.405a

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2013Volume 36Issue 5 Pages 405b
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DOIhttps://doi.org/10.2177/jsci.36.405b

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2013Volume 36Issue 5 Pages 406a
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DOIhttps://doi.org/10.2177/jsci.36.406a

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2013Volume 36Issue 5 Pages 406b
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DOIhttps://doi.org/10.2177/jsci.36.406b

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2013Volume 36Issue 5 Pages 407a
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DOIhttps://doi.org/10.2177/jsci.36.407a

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2013Volume 36Issue 5 Pages 407b
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DOIhttps://doi.org/10.2177/jsci.36.407b

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2013Volume 36Issue 5 Pages 408a
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DOIhttps://doi.org/10.2177/jsci.36.408a

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2013Volume 36Issue 5 Pages 408b
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DOIhttps://doi.org/10.2177/jsci.36.408b

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2013Volume 36Issue 5 Pages 409a
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DOIhttps://doi.org/10.2177/jsci.36.409a

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2013Volume 36Issue 5 Pages 409b
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DOIhttps://doi.org/10.2177/jsci.36.409b

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P8-04 Immunological profile of plasmacytoid dendritic cells and mast cells in Sjogren's syndrome

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2013Volume 36Issue 5 Pages 410a
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DOIhttps://doi.org/10.2177/jsci.36.410a

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Although the role of lymphocytes in the pathology of Sjogren's Syndrome (SS) has been investigated, the role plasmacytoid dendritic cells (PDCs) and mast cells (MCs) remains poorly understood.Lip biopsy specimen from 178 SS and 7 Sicca syndrome (Sicca) were analyzed for histological scores and density of PDCs and MCs. Lymphocytes infiltration, acinar atrophy and intralobular fibrosis were observed with increased pDCs and MCs in SS compared to Sicca patients. Positive correlation was observed in pDCs density with lymphocytes infiltration and MCs density with intralobular fibrosis in primary SS but not in secondary SS. Within the primary SS, CXCL13+ cells density positively correlated with lymphocyte infiltration and pDCs density. Double staining with anti-CXCL13 and anti-CD68 revealed that majority of CXCL13+ cells are macrophages, and that pDCs and CXCL13+ cells are localized at the surrounding area of the duct. Our data suggests the role of PDCs in lymphocyte infiltration and MCs in intralobular fibrosis in primary SS. Moreover, CXCL13 expression suggests the involvement of multiple lineage cells in the early stage of the disease, and MCs in the mid to late stage.

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2013Volume 36Issue 5 Pages 410b
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DOIhttps://doi.org/10.2177/jsci.36.410b

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2013Volume 36Issue 5 Pages 411a
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DOIhttps://doi.org/10.2177/jsci.36.411a

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2013Volume 36Issue 5 Pages 411b
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DOIhttps://doi.org/10.2177/jsci.36.411b

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2013Volume 36Issue 5 Pages 412a
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DOIhttps://doi.org/10.2177/jsci.36.412a

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2013Volume 36Issue 5 Pages 412b
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DOIhttps://doi.org/10.2177/jsci.36.412b

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2013Volume 36Issue 5 Pages 413a
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DOIhttps://doi.org/10.2177/jsci.36.413a

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2013Volume 36Issue 5 Pages 413b
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DOIhttps://doi.org/10.2177/jsci.36.413b

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2013Volume 36Issue 5 Pages 414a
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DOIhttps://doi.org/10.2177/jsci.36.414a

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2013Volume 36Issue 5 Pages 414b
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DOIhttps://doi.org/10.2177/jsci.36.414b

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2013Volume 36Issue 5 Pages 415a
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DOIhttps://doi.org/10.2177/jsci.36.415a

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2013Volume 36Issue 5 Pages 415b
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DOIhttps://doi.org/10.2177/jsci.36.415b

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2013Volume 36Issue 5 Pages 416a
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DOIhttps://doi.org/10.2177/jsci.36.416a

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2013Volume 36Issue 5 Pages 416b
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DOIhttps://doi.org/10.2177/jsci.36.416b

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2013Volume 36Issue 5 Pages 417a
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DOIhttps://doi.org/10.2177/jsci.36.417a

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2013Volume 36Issue 5 Pages 417b
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DOIhttps://doi.org/10.2177/jsci.36.417b

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2013Volume 36Issue 5 Pages 418a
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DOIhttps://doi.org/10.2177/jsci.36.418a

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2013Volume 36Issue 5 Pages 418b
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DOIhttps://doi.org/10.2177/jsci.36.418b

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2013Volume 36Issue 5 Pages 419a
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DOIhttps://doi.org/10.2177/jsci.36.419a

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2013Volume 36Issue 5 Pages 419b
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DOIhttps://doi.org/10.2177/jsci.36.419b

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2013Volume 36Issue 5 Pages 420a
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DOIhttps://doi.org/10.2177/jsci.36.420a

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2013Volume 36Issue 5 Pages 420b
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DOIhttps://doi.org/10.2177/jsci.36.420b

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2013Volume 36Issue 5 Pages 421a
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DOIhttps://doi.org/10.2177/jsci.36.421a

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2013Volume 36Issue 5 Pages 421b
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DOIhttps://doi.org/10.2177/jsci.36.421b

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2013Volume 36Issue 5 Pages 422a
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DOIhttps://doi.org/10.2177/jsci.36.422a

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2013Volume 36Issue 5 Pages 422b
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DOIhttps://doi.org/10.2177/jsci.36.422b

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2013Volume 36Issue 5 Pages 423a
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DOIhttps://doi.org/10.2177/jsci.36.423a

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2013Volume 36Issue 5 Pages 423b
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DOIhttps://doi.org/10.2177/jsci.36.423b

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2013Volume 36Issue 5 Pages 424a
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DOIhttps://doi.org/10.2177/jsci.36.424a

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2013Volume 36Issue 5 Pages 425a
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DOIhttps://doi.org/10.2177/jsci.36.425a

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2013Volume 36Issue 5 Pages 425b
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DOIhttps://doi.org/10.2177/jsci.36.425b

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2013Volume 36Issue 5 Pages 426a
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DOIhttps://doi.org/10.2177/jsci.36.426a

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2013Volume 36Issue 5 Pages 426b
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DOIhttps://doi.org/10.2177/jsci.36.426b

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