Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics

Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601

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Volume 10, Issue 1

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[title in Japanese]

[in Japanese]

1979 Volume 10 Issue 1 Pages 1-2
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.1

JOURNAL FREE ACCESS

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Effects of Acebutolol, a New Beta-receptor Blockade, on Premature Ventricular Contractions

Nobutaka DOBA, Yoshiaki INAGAKI, Shigeaki HINOHARA

1979 Volume 10 Issue 1 Pages 3-11
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.3

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The present study describes the anti-arrhythmic action of acebutolol, a new relatively cardioselective beta-adrenergic antagonist, on 19 patients with premature ventricular contractions, that was assessed with 24 hour ambulatory ECG monitoring. Total heart rate numbers in 24 hours were significantly reduced to 87% and 88% of control levels with 300 mg and 600 mg of acebutolol, respectively. While 300mg of acebutolol revealed significant reduction of total PVCs in 24 hours to 79% of control, 600mg of acebutolol did not show significant suppression of PVCs. As a group, diurnal variation of PVC revealed spontaneous reduction around noon and during sleep.Acebutolol, 300 mg/day, was effective in suppressing PVCs from 6 p.m. to 1 a.m. with average reduction of 43% . Double dose of acebutolol, 600 mg/day, was less effective and suppressed them only between 8 p.m. to 10 p.m. Plasma concentration of acebutolol measured by Collins' method did not correlate with the anti-arrhythmic effect of acebutolol . In conclusion, acebutolol, 300 mg/day was found to be effective in suppressing PVCs and was well tolerated without unmanageable adverse symptoms.

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Clinical Effect and Mechanism of a New Diuretic: Piretanide

Makoto MIYAMOTO, Yoshiko NAKANISHI, Hidehiro AMAMIYA, Fumio TAKAHASHI, ...

1979 Volume 10 Issue 1 Pages 13-19
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.13

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In order to clarify the mechanism of piretanide (PN), a new saluretic developed by Hoechst AG., PN 6 mg was intravenously injected to patients having at least 70 % of normal renal function and to healthy subjects as controls under the condi tions of water load and water restriction.
The following results were obtained by the renal clearance test:
1) Urine volumes markedly increased after PN administration. Peak diuresis was obtained 30 minutes following injection.
2) PN is considered to act on the diluting segment of the ascending loop of Henle, basing on the fact that CH₂O decreased under water load, whereas T^C_H2Odecreased under water restriction.
3) Urinary excretion of electrolytes increased following PN administration. The excretion of Na, Cl, K, and Ca, was particularly predominant.
4) Urine pH tended to decrease following PN administration. This loss of H⁺into the urine may potentially cause alkalosis of body fluids.

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[title in Japanese]

[in Japanese]

1979 Volume 10 Issue 1 Pages 23-24
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.23

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[title in Japanese]

[in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 25-26
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.25

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[title in Japanese]

[in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 27-29
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.27

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 30-32
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.30

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 33-34
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.33

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 35-36
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.35

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 37-39
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.37

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 40-42
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.40

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 43-44
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.43

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 45-46
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.45

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 47-48
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.47

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 49-50
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.49

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[title in Japanese]

[in Japanese], William Fennell, Leon Goldberg, [in Japanese], [in Japa ...

1979 Volume 10 Issue 1 Pages 51-54
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.51

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 55-56
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.55

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 57-58
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.57

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 59-60
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.59

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 61-62
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.61

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[title in Japanese]

[in Japanese]

1979 Volume 10 Issue 1 Pages 63-64
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.63

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 65-66
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.65

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 67-68
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.67

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[title in Japanese]

[in Japanese]

1979 Volume 10 Issue 1 Pages 69-70
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.69

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 71-73
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.71

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 74-76
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.74

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 77-78
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.77

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 79-80
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.79

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 81-82
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.81

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 83-84
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.83

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 85-86
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.85

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[title in Japanese]

[in Japanese]

1979 Volume 10 Issue 1 Pages 87-88
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.87

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 89-90
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.89

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 91-92
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.91

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 93-94
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.93

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[title in Japanese]

[in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 95-96
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.95

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 97-99
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.97

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 100-102
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.100

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 103-105
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.103

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 106-108
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.106

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 109-110
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.109

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 111-112
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.111

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 113-115
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.113

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 116-118
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.116

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 119-120
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.119

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[title in Japanese]

[in Japanese], [in Japanese], C. A. Dujovne, [in Japanese]

1979 Volume 10 Issue 1 Pages 121-122
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.121

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 123-124
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.123

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 125-126
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.125

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1979 Volume 10 Issue 1 Pages 127-128
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.127

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1979 Volume 10 Issue 1 Pages 129-130
Published: March 30, 1979
Released on J-STAGE: June 28, 2010

DOIhttps://doi.org/10.3999/jscpt.10.129

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