巻号一覧
11 巻 (1980)
- 4 号 p. 307-
- 3 号 p. 215-
- 2 号 p. 125-
- 1 号 p. 1-
11 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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赤木 公博, 村井 宏一郎, 志方 建, 山中 正義, 尾前 照雄1980 年 11 巻 2 号 p. 125-129
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーIn vitro effects of glycyrrhizin on the serum enzymes in chronic hepatitis patients were studied. Forty μg and 100 μg of glycyrrhizin per one ml of reaction mixture inhibited transaminase activity by about 10% and 32-37%, respectively, in a noncompetitive manner. The former concentration was comparable to the clinical dose by intravenous administration in the treatment of liver diseases. Glycyrrhizin also had inhibitory action on the activities of serum LDH and LAP, but not on MAO activity. Furthermore, this agent exhibited activation on acid RNase, but not on alkaline RNase.抄録全体を表示PDF形式でダウンロード (718K) -
八木橋 操六, 西平 守美, 柏村 英明, 得居 淳1980 年 11 巻 2 号 p. 131-139
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーTo study in vivo effect of methylcobalamin (CH3-B12) on the peripheral nerve structures, rats with experimental diabetes induced by streptozotocin were administered with daily intramuscular injection of CH3-B12 (500μg/kg). Improved general conditions such as an increase in body weight or ameliorated glucose intolerance were observed in the diabetic rats treated continuously with CH3-B12 for 16 weeks.
There were no definite morphometrical differences between the diabetic rats treated with CH3-B12 only for 8 weeks during the latter half of this experiment, and non-treated iabetic rats. However, the diabetic rats continuously treated with CH3-B12 for 16 weeks showed low incidence of degenerated nerve fibers and less reduction of myelinated nerve fiber density than those of npn-treated diabetic rats (p<0.01 and p<0.05).
The reduction of myelinated nerve fibers predominantly of large diameter (5-8μ) were prevente in the treated diabetic rats in contrast with those of nontreated diabetic rats on the histograms of the diameter of myelinated nerve fibers.
The results suggested that an early continuous treatment with CH3-B12 inhibited the evolution of peripheral nerve lesions in rats with experimental diabetes.抄録全体を表示PDF形式でダウンロード (1318K) -
肝硬変を対象としたPiretanide注射剤とBumetanide注射剤の等価用量の検討近藤 忠亮, 石川 泰祐1980 年 11 巻 2 号 p. 141-151
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーThe diuretic activity of piretanide injection was compared with that of bumetanide injection in 6 patients with liver cirrhosis. Drugs were allotted according to a single-blind Latin square design. The following conclusions were obtained:
1. For each drug the diuretic effect reached a maximun within 2 hours after intravenous administration, and in 4 hours the effect largely disappeared .
2. Six mg of piretanide was found to be almost equivalent to 0.5 mg of bumetanide with respect to the effects upon urinary volume and Na+ excretion.
3. The electrolyte excretion pattern obtained with piretanide was similar to that of bumetanide.
4. No changes in symptoms, abnormal laboratory data, or untoward effects were noted with either drug.抄録全体を表示PDF形式でダウンロード (1255K) -
大橋 一郎, 大谷 正洋, 公平 宏1980 年 11 巻 2 号 p. 153-159
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーThe plasmal level and urinary excretion of pirenzepine were investigated in man by radioimmunoassay after a single or multiple oral administration of pirenzepine tablets to healthy male volunteers. In a single administration (dose: 12.5, 25, 50 or 150 mg), the maximum plasma level appeared 2 hours after administration on average, the elimination half-life was about 13 hours on average, and urinary excretion rate within 96 hours was 7-12%. In multiple administration, three times a day (25 mg or 50 mg/time) for 4 days, the plasma level was observed to increase for the first 3 days of administration and to keep plateau thereafter. Also, the experimental values were in accordance with the simulation curve. These results suggested that the pharmacokinetic property of pirenzepine was not changed in different doses nor in multiple administration.抄録全体を表示PDF形式でダウンロード (696K) -
Haruki KATO, Nobuyoshi YOKOE, Shuhei TAKEMURA, Toshikazu YOSHIKAWA, Na ...1980 年 11 巻 2 号 p. 161-170
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーAnthelmintic drug levamisole, clinically used as an immunopotentiator, has been shown to restore the decreased cellular immune response. In this experiment, levamisole was found to increase serum complement level either in guinea pig or in human without malignancy, investigated by hemolytic assay using sensitized sheep erythrocytes (EA) for the classical pathway activity and unsensitized rabbit erythrocytes (RaE) for the alternative pathway activity. Assay of complement components revealed a mild increase in Clq, C4, C3, C9, and C1-inhibitor, while no specific tendency was observed in C5, properdin and C3 activator. Although leva misole provided no effect upon serum complement activation in vitro, these evi dences suggested that levamisole might potentiate immune response of the host by elevating serum complement level.抄録全体を表示PDF形式でダウンロード (1231K) -
PropranololとPindolの比較木之下 正彦, 福原 武久, 尾崎 信之, 川口 義広, 高山 幸男, 三ツ浪 健一, 加藤 正太郎, 木村 正一, 真城 巌, 河北 成一1980 年 11 巻 2 号 p. 171-179
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーThe effects of proranolol and pindolol on systemic hemodynamics at rest and during bicycle exercise with work load at 27 watts were studied in 22 outpatients. Cardiac output was measured by dye dulution method. Twelve lead electrocardiograms were taken and blood pressure was measured by cuff method. The dosages used were 20 mg of propranolol and 5 mg of pindolol. There was no significant difference in effect on heart rate between propranolol and pindolol. Propranolol significantly decreased blood pressure only on exercise, while pindolol did it at rest as well as on exercise. Propranolol decreased cardiac output on exercise to the same extent than at rest while pindolol did it only on exercise. There was no significant change in stroke index on administration of propranolol, but a significant decrease on exercise with pindolol. Propranolol decreased cardiac work index on exercise to the extent than at rest while pindolol decreased it only on exercise. There was no significant difference in effect on double products between propranolol and pindolol, both of which decreased double products at rest as well as on exercise. Although propranolol increased peripheral vascular resistance at rest as well as on exercise, pindolol did not significantly change it.
This data indicates that pindolol exerts more influence on hemodynamics on exercise than at rest except for blood pressure and double products, both of which are decreased at rest as well as on exercise.抄録全体を表示PDF形式でダウンロード (1161K) -
健常人におけるDiazepam, Placeboとの比較二重盲検試験成績柳田 知司, 加藤 伸勝, 稲永 和豊, 上山 満三1980 年 11 巻 2 号 p. 181-195
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリー中枢性筋弛緩薬afloqualoneのヒトにおける依存性の有無を検索する一法として, 本薬がヒトにおいてbenzodiazepine系薬物などの中枢抑制薬に類似する自覚的効果をもつか否かを, 年齢31～46歳の健常男子志願者8名を対象として, 3日間ずつ2回試験した.試験はdiazepamおよびplaceboを対照薬として用い, 二重盲検下に行った.本剤の割り付けは3日間ずつ2回のセッションのうち1回をafloqualone, 他をdiazepamおよびplaceboとし, afloqualoneセッションでは初日20, 2日目30, 3日目40mgを1日1回経口投与し, diazepam-placeboセッションではdiazepam5mgを初日もしくは3日目に1回経口投与した.本試験ではタッピング検査, クレペリン検査およびafloqualoneの血中濃度の測定も併せて実施した.その結果, 次の如き知見を得た.
1) Afloqualoneは20mg/1回 (常用量), 30mg/1回, 40mg/1回, diazepamは5mg/1回 (常用量) の投与でタッピング検査の上に筋弛緩作用が認められた.
2) Afloqualoneは, 大脳高次中枢には影響しないことが認められた.
3) 自覚的効果についてはdiazepamはPlaceboに比較し, アンケートI, II, IIIの項目のいくつかに統計学的に有意な肯定回答があったが, afloqualoneにはそのような傾向はほとんど認められなかった.好ましい自覚的効果の有無を質問したアソケートIVに対してはいずれの薬剤に関しても肯定回答はみられなかった.
以上の結果より, afloqualoneは常用量の倍量までの用量範囲では依存性に関連あると考えられる自覚的効果を発現せず, 本薬に精神依存性があることを示唆する知見は全く認められなかった.抄録全体を表示PDF形式でダウンロード (1790K) -
二重盲検法によるHydrocortisone Sodium Succinateとの比較山村 秀夫, 奥秋 晟, 小川 龍, 橘 直矢, 玉熊 正悦1980 年 11 巻 2 号 p. 197-205
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーThe effects of methylprednisolone sodium succinate (Solu-Medrole®) in shock were studied by the double blind technique at 32 medical centers, using hydrocor. tisone sodium succinate (Solu-Cortef®) as the active control drug. Either methylprednisolone sodium succinate or hydrocortisone sodium succinate was administered in an initial dose of 20-30 mg per kg of body weight to each of 135 patients. Any patients who failed to respond well to the initial doses were given additional doses. The effects of the steroids used were evaluated within 12 hours following the final doses.
The results obtained are as follows:
1. The general improvement rate was higher for the methylprednisolone sodium succinate group than for the hydrocortisone sodium succinate group.
2. The global utility rate was greater for the methylrednisolone sodium succinate group than for the hydrocortisone sodium succinate group.
3. Methylprednisolone sodium succinate group showed a greater improvement than the hydrocoritsone sodium succinate group in the post-treatment measurements of shock score, systolic blood pressure, pulse pressure, shock index, urinary output, arterial blood pH and Base Excess.抄録全体を表示PDF形式でダウンロード (1114K) -
安原 一, 渡部 泰久, 笠原 多嘉子, 坂本 浩二1980 年 11 巻 2 号 p. 207-213
発行日: 1980/07/30
公開日: 2010/06/28
ジャーナル フリーPharmacokinetics of amikacin (200 mg/body, im) was studied in the bedridden elderly patients, in comparison with those in normal healthy volunteers and elderly volunteers.
Elimination of amikacin from plasma was seen to follow the course of delete one compartment model system. Interindividual variations in serum concentration were observed in the bedridden elderly patients. Values for the following pharmacokinetic parameters were obtained: Elimination rate constant (Kel) =0.461±0.069 hr-1, biological half life (T1/2) =1.53±0.24 hr, volume of distribution (Vd) =0.236±0.025 1/kg for normal healthy volunteers (n=4), Kel =0.208±0.05 hr-1, T1/2 =3 .55±1.02 hr, Vd=0.376±0. 091 1/kg for bedridden elderly patients (n=5), Kel=0.303±0.026hr-1, T1/2=2.30±0.19hr, Vd=0.263±0.032 1/kg for elderly volunteers (n=3).
Cumulative renal excretion of amikacin was 36.3% of total dose by 6 hrs for bedridden elderly patients, 62.5% for elderly volunteers and 79.3% for normal healthy volunteers. Decreased renal excretion of amikacin was related to decreased renal function due to aging and increased Vd.抄録全体を表示PDF形式でダウンロード (890K)
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