Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
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Volume 2, Issue 2
Displaying 1-17 of 17 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 107-112
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.107
    JOURNAL FREE ACCESS
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  • A Rapid and Sensitive Method for Simultaneous Determination of Epinephrine and Norepinephrine in Human Plasma (Report II)
    Hideya Saito
    1971 Volume 2 Issue 2 Pages 113-118
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.113
    JOURNAL FREE ACCESS
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    As previously reported, a preliminary experiment was set up in order to run a comparision among various methods using trihydroxyindole reaction with respect to the recovery, accuracy and rapidity. The present work deals with an improvement of Price's method for simultaneous determination of epinephrine and norepinephrine in human plasma. The improvements were as follows.
    1) Purification of acid washed aluminum oxide (Merck #71695 acid washed)
    2) Addition of a large amount of EDTA disodium.
    3) Prevention of change in fluorescence intensity arising from progressive decay of fluorescence of trihydroxyindole compounds formed.
    Thus, the determination method was considerably improved in accuracy and rapidity. Using this method, it was shown that while in normal subjects almost no plasma catecholamine was detected, in the patients investigated sporadic detection was made in some diseases, in which catecholamine detection hitherto may have been difficult.
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  • Drug Dependence Liability of Calcium N-2-ethylhexyl-β-oxybutyramide semisuccinate (M-2) Tested in Rhesus Monkeys
    Tomoji Yanagita, Saburo Takahashi
    1971 Volume 2 Issue 2 Pages 119-125
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.119
    JOURNAL FREE ACCESS
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    Barbiturate-like drug dependence liability of Calcium N-2-ethylhexyl-β-oxybutyramide semisuccinate (M-2), a new synthetic sedative-hypnotic agent, was studied in rhesus monkeys.
    In gross behavior observation of acute CNS effects, the compound did not show as strong CNS depressant effects in monkeys as it had in small animals.
    A physical dependence producing test was conducted by oral administration of the compound 4 times a day, for 4 weeks at dose levels of 100, 200, or 400 mg/kg/day, with 2 naive monkeys for each dose level. At the end of 4 weeks, administration was terminated and a withdrawal test was conducted for 5 days. No meaningful withdrawal signs were observed. On the other hand, oral administration of barbital for 4 weeks produced intermediate to severe grade withdrawal signs in other monkeys.
    In cross intravenous self-administration of M-2, a CNS stimulant and saline in self-administration conditioned monkeys, the compound did not show drug seeking behavior reinforcing effects at unit doses of 0.25, 1.0, and 4.0 mg/kg/inj..
    Because of the lack of CNS depressant effects, ability of producing physical dependence and drug seeking behavior reinforcing effects, the potency of dependence liability of M-2 was concluded as practically none.
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  • Drug Dependence Liability of 4β-Methoxy-1-methyl-4α-phenyl-3α, 5α propanopiperidine hydrogen citrate (Azabicyclane) Tested in Rhesus Monkeys
    Tomoji Yanagita, Saburo Takahashi, Nagaoki Oinuma
    1971 Volume 2 Issue 2 Pages 126-134
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.126
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    Morphine-like drug dependence liability of Azabicyclane, a new synthetic analgesic compound, was studied in rhesus monkeys.
    In gross behavior observation of acute CNS effects, the compound showed CNS depressant and toxic effects which were more similar to those of pethidine than to those of morphine.
    In the cross physical dependence test in monkeys, made physically dependent on morphine and then withdrawn, the compound did not support the dependence when it was substituted for morphine. Furthermore, the compound was antagonistic to morphine and precipitated withdrawal signs in morphine-dependent, non-withdrawn monkeys. However, when the compound was repeatedly administered to naive monkeys for a period of 31 days, severe grade withdrawal signs were observed in the levallorphan withdrawal and natural withdrawal tests.
    In cross intravenous self-administration of the compound, a CNS stimulant, and saline in self-administration conditioned monkeys, the compound showed obvious drug seeking behavior reinforcing effects at an appropriate unit dose range.
    When both naive and self-administration conditioned monkeys were allowed to self-administer the compound intravenously, without time or dose limitation, the animals voluntarily initiated self-administration, gradually increased the daily dose, and continued self-administration for longer than 6 weeks. The monkeys manifested marked CNS effects during this period. However, pethidine-like, psychotonaimetic effects were not observed.
    Therefore, although the pharmacological properties of Azabicyclane in connection with drug dependence, were not identical with those of pethidine, the potency of dependence liability, both physical and psychological, was similar to that of pethidine.
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  • Compartment theory
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 135-146
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.135
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 147-156
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.147
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 157-168
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.157
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 169-174
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.169
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 175-178
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.175
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 179-188
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.179
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 189-195
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.189
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 196-200
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.196
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 201-207
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.201
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 208-211
    Published: April 30, 1971
    Released on J-STAGE: February 25, 2011
    DOIhttps://doi.org/10.3999/jscpt.2.208
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 212-215
    Published: April 30, 1971
    Released on J-STAGE: June 28, 2010
    DOIhttps://doi.org/10.3999/jscpt.2.212
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1971 Volume 2 Issue 2 Pages 216-221
    Published: April 30, 1971
    Released on J-STAGE: February 25, 2011
    DOIhttps://doi.org/10.3999/jscpt.2.216
    JOURNAL FREE ACCESS
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  • Erratum
    1971 Volume 2 Issue 2 Pages 223
    Published: 1971
    Released on J-STAGE: February 25, 2011
    DOIhttps://doi.org/10.3999/jscpt.2.2_223
    JOURNAL FREE ACCESS
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