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Volume 3 (1972)
- Issue 4 Pages 281-
- Issue 3 Pages 179-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 3, Issue 2
Displaying 1-15 of 15 articles from this issue
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[in Japanese], [in Japanese]1972 Volume 3 Issue 2 Pages 89-90
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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Zenichi Umene, Kazusuke Uriu, Midori Kurata, Masao Minagawa, Takashi N ...1972 Volume 3 Issue 2 Pages 91-102
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSA double-blind controlled study of therapeutic effects of pimozide were made in comparison with those of chlorpromazine.
Subjects were 92 hospitalized schizophrenics, setting up in 46 pairs of the same sex, similar clinical conditions and with less than ten years disparity in age.One patient receiving chlorpromazine was dropped out after 4 weeks.
After a one-week wash-out period, patients were first given daily 3 tablets (1 mg/tab.) of pimozide in a single dose or 6 tablets (25 mg/tab.) of chlorpromazine in three divided doses. The dose was then individualized depending on the symptoms in ratio of 1 tablet pimozide and 2 tablets chlorpromazine, within thelimits of 12 tablets or 24 tablets a day respectively.
Global Comparative Judgement after 4 and 8 weeks' administration revealed no statistically significant difference between two drug groups in the sequential analysis. In General Improvement Rating after 8 weeks' administration, pimo zide caused improvement slightly better than chlorpromazine . Pimozide showed higher improvement rate than chlorpromazine after 8 weeks in items of “hal lucination”, “contact”, “working ability” and “care of clothing”.
Incidence of side effects revealed no statistically significant difference between two except for salivation. Laboratory tests were also performed in all the subjects.View full abstractDownload PDF (1586K) -
Investigations of dose-response relationshipTomohide Nagatomo1972 Volume 3 Issue 2 Pages 103-107
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSTwenty healthy male and female volunteers received at random and a new antispas-modic agent, SA-504, at the i.v. dose levels of 0.3, 0.9, 2.7, and 8.1 mg/body under the double blind conditions, and gastric motility and gastroduodenal tone were compared roentgenographically with those of the same subjects before treatment. The ED 50 and ED 80 of SA-504 were determined from the dose-response relationship. SA-504 did not show the inhibitory action on the gastric motility and gastroduodenal tone at the dose of 0.3 mg/body. Inhibitory action was observed at 0.9 and 2.7 mg/body in about a half of the subjects, and at 8.1mg/body remarkable action was seen in almost all subjects. With an in-hibitory action of more than_??_ being regarded as clinically effective, the ED 50 and ED 80 of SA-504 (mg/body) were calculated to be 2.66 and 8.21 on the gastric motility, 2.40 and 7.2 on the tone of the stomach, and 2.17 and 6.56 on duodenal tone, respectively. The optimal effective dose of SA-504 was estimated to be 7-8 mg/body in functional gastrointenstinal disorders. No side effects were noted except dizziness in one case given the maximum dose and dizziness and palpitation in another case receiving 0.9 mg/body.View full abstractDownload PDF (595K) -
Shoichi Sakamoto, Hitoshi Fujii, Masanobu Hogaki, Tsuyoshi Inoue, Masa ...1972 Volume 3 Issue 2 Pages 108-117
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSA double blind controlled study on the analgesic effect of dextropropoxyphene napsylate (DPN) was carried out in 65 postpartum patients. Patients were given a single oral dose DPN 100 mg/kg or“Sedes” 0.5g (contains cyclobarbital aminopyrine 92 mg, aminopyrine 54mg, phenacetin 200mg, and caffeine 70 mg in each 0.5 g) and pain intensity, classified into 4 grades, was statistically compared. The results obtained were as follows:
1) An analgesic effect of DPN on uterine pain was clearly observed, but the potency was significantly lower than that of “Sedes”.
2) For postepisiotomy pain, DPN was superior to“Sedes”, but the difference was not significant.
3) In side effect observation, only drowsiness was observed with both drugs, in 2 cases for each drug.View full abstractDownload PDF (1337K) -
[in Japanese]1972 Volume 3 Issue 2 Pages 118-121
Published: June 30, 1972
Released on J-STAGE: February 25, 2011
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[in Japanese]1972 Volume 3 Issue 2 Pages 122-123
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 124-128
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 129-133
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 134-145
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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Fuminae Kubo1972 Volume 3 Issue 2 Pages 146-151
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 152-157
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 158-162
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 163-169
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 2 Pages 173-175
Published: June 30, 1972
Released on J-STAGE: June 28, 2010
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1972 Volume 3 Issue 2 Pages 175
Published: 1972
Released on J-STAGE: February 25, 2011
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