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Volume 31 (2000)
- Issue 6 Pages 146E-
- Issue 5 Pages 633-
- Issue 4 Pages 547-
- Issue 3 Pages 45E-
- Issue 2 Pages 213-
- Issue 1 Pages 1-
Volume 31, Issue 4
Displaying 1-18 of 18 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2000 Volume 31 Issue 4 Pages 547-555
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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Katsutoshi OGAWA, Kayoko HASHIMOTO, Osamu MATSUOKA, Hisakuni SEKINO, S ...2000 Volume 31 Issue 4 Pages 557-563
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSThe rapid ACTH test is used to evaluate adrenocortical function in healthy subjects in phase I studies. Several criteria have previously been reported for patients. However, each of the evaluations are not necessarily applicable for healthy subjects.
The purpose of this study was to determine which criterion is the most suitable for healthy subjects in phase I studies. We enrolled 244 healthy male subjects, aged 20-39, who gave written informed consent before entering the study. They underwent the standard rapid ACTH test, consisting of measurement of plasma cortisol levels before and at 30 and 60 minutes after intravenous injection of 0.25 mg tetracosactide acetate (Cortrosyn ®). Cortisol levels were measured by GammaCoat antibody-coated tube radioimmunoassay.
When the adrenocortical function of healthy subjects was evaluated by the criteria of the increment (peak level minus initial cortisol level) or the ratio (peak level/initial level), unreasonable results were obtained in that those with a higher initial cortisol level, tended to fall outside of some of the criteria. Therefore these criteria do not seem suitable for healthy subjects in phase I studies. We consider that the criterion of the peak cortisol level is more applicable than the criteria, because at least it did not give unreasonable results. The findings suggest that a peak cortisol level of greater than or equal to 20μg/dl, as evaluated by the rapid ACTH test, is a sufficient criterion for healthy subjects in phase I studies.View full abstractDownload PDF (728K) -
[in Japanese]2000 Volume 31 Issue 4 Pages 567-568
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 569-570
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 571-572
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 573-574
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 575-576
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 577-578
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 579
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 581-582
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 583-584
Published: July 31, 2000
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[in Japanese], [in Japanese]2000 Volume 31 Issue 4 Pages 586
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 587-588
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese]2000 Volume 31 Issue 4 Pages 589-592
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 593-597
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 599-604
Published: July 31, 2000
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[in Japanese]2000 Volume 31 Issue 4 Pages 605-613
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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[in Japanese]2000 Volume 31 Issue 4 Pages 614-621
Published: July 31, 2000
Released on J-STAGE: June 28, 2010
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