Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
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Volume 38, Issue 6
Displaying 1-9 of 9 articles from this issue
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Feature Articles : Present Status and Future Prospect of Molecular Targeting Therapy
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  • The Effect of Loratadine on Psychomotor Function in Healthy Japanese Subjects : Comparison with d-Chlorpheniramine Maleate and Placebo in a Double-Blind 4-Way Crossover Study
    Shigeyuki NAKANO, Yukiko SUNAMI, Shin IRIE, Kyoko MATSUGUMA, Hiroshi T ...
    2007 Volume 38 Issue 6 Pages 401-407
    Published: November 30, 2007
    Released on J-STAGE: October 31, 2008
    DOIhttps://doi.org/10.3999/jscpt.38.401
    JOURNAL FREE ACCESS
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    The effect of loratadine, a new antihistamine, on psychomotor function was investigated in healthy Japanese volunteers using accuracy of typing figures into a personal computer as the index in a Latin-square double-blind crossover study with d-chlorpheniramine maleate as positive control and placebo as negative control. Twenty subjects typed figures for 15 minutes at 2 hours after receiving a single dose of 10 mg or 20 mg of loratadine after breakfast. The number of correct entries was counted automatically per subject as the primary variable. In the chlorpheniramine group the number of correct entries was significantly less than in the placebo and loratadine 10 mg and 20 mg groups (p<0.05, p<0.05, and p<0.01, respectively). No significant difference was observed between the placebo, loratadine 10 mg, and loratadine 20 mg groups. The results suggest that loratadine, unlike d-chlorpheniramine maleate, does not affect psychomotor function at either the usual dose of 10 mg or at twice the usual dose (20 mg).
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