臨床薬理
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
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40 巻, 2 号
選択された号の論文の38件中1～38を表示しています
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ORIGINAL
  • The Inhibitory Effect of Cranberry Juice on Phenytoin Metabolism by Human Liver Microsomes
    Kentarou USHIJIMA, Taka-aki KOSHIMIZU, Akio FUJIMURA
    2009 年 40 巻 2 号 p. 59-64
    発行日: 2009年
    公開日: 2009/08/12
    DOIhttps://doi.org/10.3999/jscpt.40.59
    ジャーナル フリー
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    CYP2C9 is involved in the metabolism of many drugs such as warfarin and phenytoin (PHT). It is well known that some foods cause pharmacokinetic alterations of drugs and lead to toxicity. Regarding the interaction caused by cranberry juice (CrJ), its influence on the metabolism of warfarin, a CYP2C9 substrate, is controversial. In addition, information concerning the influence of CrJ on the pharmacokinetics of other substrate drugs of CYP2C9 is not available. To examine the inhibitory effect of CrJ on the metabolism of PHT, we performed experiments using a baculovirus expression microsome system and human liver microsome assay. CrJ concentration-dependently inhibited the substrate metabolism both in a baculovirus-expressed microsome system and in human liver microsome assay. These data support the idea that CrJ inhibits CYP2C9 activity, and the subsequent metabolism of drugs metabolized by CYP2C9. In this study, we did not identify the specific substance(s) which inhibits CYP2C9 activity. However, as CrJ did not enhance the PHT accumulation in 3D-HepG2 cells, it is thought that the penetration into hepatic cells of inhibitory substances in CrJ seems to be small.
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第29 回日本臨床薬理学会年会記録
シンポジウム4　インフルエンザ罹患後の異常行動をめぐって
シンポジウム5　医薬品開発とバイオマーカー―抗がん薬を中心に―
シンポジウム6　CRC 研修のあり方：導入研修からadvanced 研修まで
シンポジウム9　第 4 回日本臨床薬理学会／日本薬理学会共催シンポジウム：アルドステロンをめぐって
シンポジウム12　新規ゲノム薬理学の展開
ワークショップ3　研究審査委員会委員の教育
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