Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
Search
Advanced search
OR
Browse
Search
Volume 40, Issue 3
Displaying 1-36 of 36 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Original
  • Pharmacokinetics of Ephedrine and Pseudoephedrine after Oral Administration of Kakkonto to Healthy Male Volunteers
    Nobuo INOTSUME, Shoji FUKUSHIMA, Toru HAYAKAWA, Shuichi KISHIMOTO, Hit ...
    2009 Volume 40 Issue 3 Pages 79-83
    Published: 2009
    Released on J-STAGE: August 12, 2009
    DOIhttps://doi.org/10.3999/jscpt.40.79
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The pharmacokinetics of serum ephedrine and pseudoephedrine as the indexed reference ingredients of Kampo Kakkonto (ge-gen-tang in Chinese) were compared after the oral administration of 2.5 g and 3.75 g of Kakkonto extract. The mean maximal serum concentrations of ephedrine and pseudoephedrine obtained after the administration at 3.75 g were 1.50- and 1.58-fold higher (p<0.05), respectively, than those obtained after the administration of 2.5 g, whereas the time required to reach the maximal concentration did not significantly differ between the two doses. The mean areas under the concentration-time curves of ephedrine and pseudoephedrine obtained after the 3.75 g of Kakkonto were 1.31- and 1.48-fold higher (p<0.05), respectively, than those obtained after the 2.5 g dose, while no significant differences were observed in the mean residence time and elimination rate constant of the terminal phase between the doses. Disposition profiles showed that the kinetic behavior of ephedrine and pseudoephedrine were largely linear at the doses examined.
    View full abstract
    Download PDF (58K)
Proceedings of the 15th Training Course in Clinical Pharmacology : Reliability Activity in Clinical Study
Proceedings of the 29th Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
Symposium 1 “How to Conduct Early Phase of Clinical Trial”
Symposium 8 “Adverse Effects and Adverse Drug Reactions”
Symposium 11 “Roles of Randomised Clinical Trial and Observational Study in Solving Clinical Questions”
Symposium 13 “Consideration on Study Design”
Workshop 2 “Case Studies of Clinical Pharmacological Approaches to Patients with Therapeutic Dilemmas”
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top