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[in Japanese], [in Japanese]
1976 Volume 7 Issue 1 Pages
1-2
Published: March 30, 1976
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Masatoshi TANAKA, Hiroshi ISOZAKI, Kazutoyo INANAGA
1976 Volume 7 Issue 1 Pages
3-12
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It is very important for knowing the drug effects on sleep to search for not only the self-assessments of sleep on the nights when the drugs were administered but also the electrophysiologically recorded sleep on these nights. Concerned with these studies, many kinds of experimental designs have been used.
The authors undertook the cross over design for investigating the effects of the new triazolobenzodiazepine derivative, estazolam on the all-night sleep pattern. In the present study, problems on choice of the baseline nights and the values of sleep parameters which offered more suitable informations on drug effects, were reported.
Four healthy, male adults, ranging in ages from 29 to 40 years, were subjected to this study. The subjects were administered placebo on the first and the second nights and the active drugs on the third night and placebo on the fourth night, again by double-blind method.
Sleep records were obtained on these four consecutive nights. These trials were repeated four times for each subject.
In the second placebo nights (P
2), total sleep time and stage REM tended to increase and stage 4 tended to decrease, compared with the first placebo nights (P
1). So, it was suggested to be more suitable to choose P
2 as baseline value rather (P
1 + P
2) /2, for P
1 was more biased than P
2.
The two values: (D-P
2) /P
2 (D: drug night) and (D-P
2) were compared to obtain such values that offered more abundant informations on drug efficacies.
There were no great differences between these two values. But, (D-P
2) /P
2were unlikely to be suitably corrected, because for example, as to total sleep time, P
2 was inversely correlated to (D-P
2).
From these results, it is concluded that in the present study it is suitable to use P
2 as the baseline values and to use (D-P
2) for studying the drug efficacies.
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1976 Volume 7 Issue 1 Pages
15-16
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1976 Volume 7 Issue 1 Pages
17-18
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1976 Volume 7 Issue 1 Pages
19-20
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1976 Volume 7 Issue 1 Pages
21-22
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1976 Volume 7 Issue 1 Pages
23-24
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1976 Volume 7 Issue 1 Pages
25-26
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1976 Volume 7 Issue 1 Pages
27-28
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1976 Volume 7 Issue 1 Pages
29-30
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1976 Volume 7 Issue 1 Pages
31-32
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1976 Volume 7 Issue 1 Pages
33-34
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1976 Volume 7 Issue 1 Pages
35-36
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1976 Volume 7 Issue 1 Pages
37-38
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1976 Volume 7 Issue 1 Pages
39-40
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1976 Volume 7 Issue 1 Pages
41
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1976 Volume 7 Issue 1 Pages
43-44
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1976 Volume 7 Issue 1 Pages
45-46
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1976 Volume 7 Issue 1 Pages
47-48
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1976 Volume 7 Issue 1 Pages
49-50
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1976 Volume 7 Issue 1 Pages
51-52
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1976 Volume 7 Issue 1 Pages
53-54
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1976 Volume 7 Issue 1 Pages
55-56
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1976 Volume 7 Issue 1 Pages
57
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1976 Volume 7 Issue 1 Pages
59-60
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1976 Volume 7 Issue 1 Pages
61
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1976 Volume 7 Issue 1 Pages
63-64
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1976 Volume 7 Issue 1 Pages
65-66
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1976 Volume 7 Issue 1 Pages
67-68
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1976 Volume 7 Issue 1 Pages
69-71
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1976 Volume 7 Issue 1 Pages
73-74
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1976 Volume 7 Issue 1 Pages
75-76
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1976 Volume 7 Issue 1 Pages
77-78
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1976 Volume 7 Issue 1 Pages
79-80
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1976 Volume 7 Issue 1 Pages
81-83
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1976 Volume 7 Issue 1 Pages
85-86
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1976 Volume 7 Issue 1 Pages
87
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1976 Volume 7 Issue 1 Pages
89-90
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1976 Volume 7 Issue 1 Pages
91-92
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1976 Volume 7 Issue 1 Pages
93-94
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1976 Volume 7 Issue 1 Pages
95-96
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1976 Volume 7 Issue 1 Pages
97-98
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[in Japanese]
1976 Volume 7 Issue 1 Pages
99-102
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1976 Volume 7 Issue 1 Pages
103-116
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1976 Volume 7 Issue 1 Pages
117
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1976 Volume 7 Issue 1 Pages
118-119
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1976 Volume 7 Issue 1 Pages
120-121
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1976 Volume 7 Issue 1 Pages
122-123
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1976 Volume 7 Issue 1 Pages
124-125
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[in Japanese]
1976 Volume 7 Issue 1 Pages
126-129
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