巻号一覧
8 巻 (1977)
- 4 号 p. 421-
- 3 号 p. 265-
- 2 号 p. 137-
- 1 号 p. 1-
8 巻, 2 号
選択された号の論文の11件中1～11を表示しています
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斉藤 章二1977 年 8 巻 2 号 p. 137-138
発行日: 1977/06/30
公開日: 2010/06/28
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至適濃度の検討高梨 雄藏, 柳田 英夫, 吉田 貞夫, 杉田 暉道1977 年 8 巻 2 号 p. 139-154
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーA double blind controlled study was conducted to compare the efficacy of 0.25% desoximetasone and 0.05% desoximetasone. 72 patients with the same skin lesion (acute eczema-like dermatitis or atopic dermatitis) on both sides of the body were selected for the study. One preparation was randomly chosen to be applied to the right side and the other was then applied to the left side two or three times a day. No occlusion was used. The data collected according to the degree of general improvement in each patient's skin condition, the posttreatment severity of his symptoms and the degree of utility was analyzed by the analysis of variance method. Data concerning relative effectiveness and relative utility was analyzed by Scheffë's paired comparison method.
For patients with acute eczema-like dermatitis, 0.25% desoximetasone proved to be statistically superior to 0.05% desoximetasone in such evaluation items as relative effectiveness, relative utility and posttreatment papule severity. With atopic dermatitis patients, no significant difference between the two concentrations was noted in any of the evaluation items.
Neither of the two concentrations produced any side effects. Both preparations proved to have an excellent therapeutic effect. 0.25% desoximetasone is considered to be more useful than the 0.05% concentration, however, particularly when the two preparations are used against the early stages of eczematous dermatitis.抄録全体を表示PDF形式でダウンロード (2393K) -
松本 慶蔵, 斉藤 玲, 横山 紘一, 楠 正, 小里 芳顕1977 年 8 巻 2 号 p. 155-168
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーPatients with pneumonia have a variety of symptoms such as dyspnea, cyanosis, cough, rales, fever, chest pain, leukocytosis, increase of erythrocyte sedimentation rate, all of which do not appear, deteriorate or improve in a parallel manner. For making objective assessments in adequate and well controlled clinical investigations, it is favorable to use a rating scale which is well characterized both by the assessment criteria of the individual symptoms and by the investigation on the relationship between the various symptoms. Although some works on this subject have been done, the assessment method is not well established.
In this paper, data on 72 cases with bacterial pneumonia being applied, assess ment criteria for chest X-ray films is discussed, and factor analytic approach is adopted to examine the basic structure of symptoms including findings on X-ray films. Three factors were extracted, each of which was characterized by a corresponding group of symptoms such as cyanosis, rales etc. for the first factor, cough and sputum for the second, fever and other general symptoms for the third. It was turned out that the first followed by the second symptom group showed speedy recovery, whereas improvement of the third group was clearly delayed; the disappearance ratio after two-week treatment was 78.6%, 81.8%, 13.9% in the first, second and third symptom group respectively. Correlation of subjective global judgement with these characteristic inclinations of each symptom group observed here was also investigated, and finally, a tentative rating scale for the assessment of chemotherapy on pneumonia is proposed.抄録全体を表示PDF形式でダウンロード (7754K) -
佐久間 昭, 石神 嚢次, 三田 俊彦, 楠 正, 田島 広久1977 年 8 巻 2 号 p. 169-181
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーIn clinical evaluations of chemotherapy, operational rating scales for clinical states or their changes have usually been employed to integrate and summarize several symptoms or signs.
This report describes an attempt to establish a rating scale for chemotherapy on simple acute cystitis. The data applied here were taken from a double blind study which was carried out lately to evaluate the efficacy of pivmecillinam including 216 cases with simple acute cystitis. For this study, subjective global judgement on the effect of chemotherapy was available together with data of four target symptoms: urinary frequency, pain during urination, WBC in sediment and bacterial count in urine.
Statistical analyses on interrelationship revealed considerable high correlation between global judgement and individual changes in symptoms, strongly suggesting that global judgement could be validly explained by these symptoms. Since changes in symptoms correlated with each other, one of them, pain during urination, could be dropped without loss of statistical efficiency. In adopting the remaining three symptoms, the squared multiple correlation coefficient R2 was 0.835, the correlaton ratio in Hayashi's quantification theory η2 was 0.880, and WBC had the largest weight in the estimation. As the result of these analyses, a simple scale of scores 0-8 was tentatively established, which agreed satisfactorily with global judgement; the agreement ratio was 87.7%.抄録全体を表示PDF形式でダウンロード (1551K) -
奥村 英正1977 年 8 巻 2 号 p. 183-184
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーPDF形式でダウンロード (358K) -
前臨床研究についてWilliam D' Aguanno1977 年 8 巻 2 号 p. 185-191
発行日: 1977/06/30
公開日: 2010/06/28
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FDA AND PMA COMMITTEES1977 年 8 巻 2 号 p. 193-201
発行日: 1977/06/30
公開日: 2010/06/28
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英国Medico-Pharmaceutical Forum委員会October 19741977 年 8 巻 2 号 p. 203-218
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーPDF形式でダウンロード (3343K) -
1977 年 8 巻 2 号 p. 219-234
発行日: 1977/06/30
公開日: 2010/06/28
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「薬品管理の臨床薬理学的評価」シンポジウムを中心として鈴木 哲哉1977 年 8 巻 2 号 p. 235-242
発行日: 1977/06/30
公開日: 2010/06/28
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アメリカ臨床薬理学会のシンポジウム山岡 静三郎, 加藤 昭, 高階 経和1977 年 8 巻 2 号 p. 243-247
発行日: 1977/06/30
公開日: 2010/06/28
ジャーナル フリーPDF形式でダウンロード (899K)
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