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Volume 9 (1978)
- Issue 4 Pages 353-
- Issue 3 Pages 235-
- Issue 2 Pages 139-
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Volume 9, Issue 3
Displaying 1-15 of 15 articles from this issue
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[in Japanese]1978 Volume 9 Issue 3 Pages 235-236
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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A Double-blind Cross-over StudyRyotaro SAITO, Takashi HOSONO, Seiichi HIMENO, Masanori KUROKAWA, Suna ...1978 Volume 9 Issue 3 Pages 237-250
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSThe effect of trimebutine on the digestive tract motility was studied in 4 healthy male volunteers by means of a crossover technique under the double-blind condition. The subjects were administered each dose of trimebutine 0, 100, 200 and 300mg in randomly assigned order, respectively on different days. An X-ray study was performed to evaluate the effect of trimebutine on gastric emptying time, gastric motility and intestinal transit time.
The results obtained were as follows:
1) Gastric emptying time showed a dose dependent increasing tendency and statistical significance was observed in the case given 200 mg or 300 mg of trimebutine in comparison with the case of 0 mg.
2) No influence of trimebutine on gastric tonus and gastric peristalsis was observed
3) Intestinal transit time tended to be slightly shorten, irrespective as to wheather it is due to direct or secondary effect of the drug.View full abstractDownload PDF (3374K) -
Hideo FUKAZAWA, Masako HONDA, Hiroko ICHISHITA, Hirotoshi SHIMIZU1978 Volume 9 Issue 3 Pages 251-265
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSBlood level profiles of flunitrazepam and its N-desmethyl-metabolite were in vestigated after single and multiple administrations of flunitrazepam to groups of 5 healthy male adult volunteers. Urinary excretion of some major metabolites of flunitrazepam was also examined following oral doses of a single 4 mg.
Following the oral administration, the absorption of flunitrazepam was fairly rapid: the peak times were attained within 1-2 hr with peak levels of 9.6-16.0 ng/ml for 2 mg dose and 20.6-30.3 ng/ml for 4 mg dose. The drug then disappear ed from the blood biphasically. The rate of disappearance was independent of the doses, while the AUC for the unaltered drug was dose-related. Blood levels of N-desmethyl flunitrazepam were always lower than those of the unal tered drug. 7-Amino-flunitrazepam and 3-hydroxy-flunitrazepam were major urinary metabolites, comprising about 9% and 5% of the dose, respectively, in the initial 72-hr urine. During repeated administration of the drug at a daily oral dose of 2 mg, the blood level profiles showed gradual elevation during the first few days, and then the steady-state was attained within 3-5 days.
After i. v. injection of 2 mg, flunitrazepam was eliminated from the blood triphasically. The mean AUC for the unaltered drug obtained after the i. v. injection was about twice as much as that obtained after the oral administration of the identical dose.View full abstractDownload PDF (2158K) -
Setsuya TAKEUCHI, Tadao OKAMURA, Kazuhiro SHICHINOHE, Kazumasa NAKAMA1978 Volume 9 Issue 3 Pages 267-275
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSEffect of long term administration of tolbutamide was histopathologically studied in 36 male alloxan diabetes rabbits. After the continuous tolbutamide administration for 3-6 months, the heart and kidney were light-and electron microscopically examined. Severe focal degenerative lesions, consisting of damages in small blood vessel and cardiac muscle, were found in the heart from the alloxan rabbits, and not a few exudative lesions and sclerotic changes of nodular or diffuse forms were seen in their renal glomeruli. From the tolbutamide-ad ministrated alloxan rabbits, qualitatively similar findings to the above were obtained, but there were many severe cases in this group. Especially, the incidence of severe cardiac lesions significantly increased in the rabbits which received tolbutamide for 6 months.
It was suggested that tolbutamide might indirectly act on the diabetic process in the alloxan rabbits.View full abstractDownload PDF (7238K) -
Kazumasa NAKAMA, Tadao OKAMURA, Kou OKAMOTO, Yo FUJIE, Kyo FUJIE, Sets ...1978 Volume 9 Issue 3 Pages 277-287
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSElectro-retinogram in alloxan rats showed attenuation in the amplitudes of waves and significant attenuation or abolishment of oscillatory wavelet in agree ment with the findings for diabetes mellitus. Prolonged administration of tolbu tamide increased the wave amplitude of ERG for alloxan rats but failed to abolish oscillatory wavelet, a characteristic syndrome of diabetes. And the treatment of normal rats increased both the a-and the a+b wave amplitudes without changing the wave configuration of ERG. It is, thus, considered that the increase in the wave amplitude of ERG may not be an indirect effect of long term administration of tolbutamide through the improvement of diabetic process itself but rather its direct action on retinal cells. In mongolian gerbils (Meriones unguiculatus), the ERG did not show any changes which might be due to diabetic process as men tioned in the experiment on alloxan diabetes rats.View full abstractDownload PDF (4222K) -
An in Vitro StudyTatsushi FUJITA, Eiji MIYAKAWA1978 Volume 9 Issue 3 Pages 289-293
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 295-299
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese], [in Japanese]1978 Volume 9 Issue 3 Pages 301-309
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 311-315
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 317-322
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 323-328
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 329-333
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 335-342
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 343-346
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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[in Japanese]1978 Volume 9 Issue 3 Pages 347-349
Published: September 30, 1978
Released on J-STAGE: June 28, 2010
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