In this study, we propose a test procedure for testing sequentially whether the response can be expressed by a linear trend with increasing dose levels in a dose response experiment. For realizing our sequential test procedure, we apply group sequential procedure to test sequentially the hypotheses of orthogonal contrasts among the population means to express a linear trend of the response. If we can first detect a linear trend at an early stage in the sequential test, it is possible to terminate the procedure with a few data up to the stage. Thus, the procedure is useful from an economical point of view when high costs are involved for obtaining the data.
In the procedure, we give an integral formula to determine the clitical limits for satisfying a predefined type I familywise error rate. Furthermore, we show how to decide a required sample size at each dose with guaranteeing the power of the test. In our simulation studies, we compare the superiority among the test procedures based on three α spending functions for various configurations of population means in terms of the power of the test and the required sample size.
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