Animal Eye Research
Online ISSN : 2185-8446
Print ISSN : 0286-7486
ISSN-L : 0286-7486
Volume 24, Issue 1-2
Displaying 1-2 of 2 articles from this issue
Original Report
  • Takeshi SHIRAKI, Masaki SHIGETA, Noriko TAHARA, Hatsue FURUKAWA, Hiroh ...
    Article type: Original Report
    2005 Volume 24 Issue 1-2 Pages 1-2_1-1-2_5
    Published: June 20, 2005
    Released on J-STAGE: March 28, 2015
    JOURNAL FREE ACCESS
    Effects of atropine and pilocarpine on a tear production were assessed in mice, rats and dogs by using commercialized Schirmer tear test strips. The test strips were cut into strips of 1.5 mm width for mice, 3.0 mm width for rats and 5.0 mm width for dogs. Atropine was injected subcutaneously at 1 mg/kg for mice, rats and dogs, and pilocarpine was injected subcutaneously at 30 mg/kg for mice and rats or at 3 mg/kg for dogs. In all species, this Schirmer tear test was detected a decrease in tear production after the treatment of atropine and an increase after the treatment of pilocarpine. These results suggest that measurement of the tear production can be performed in various species by a use of variable width of the commercialized Schirmer tear test strips, and this modified method is useful for assessment of visual toxicity.
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