The postural blood pressure reflex after a change of posture has been studied by Prof. K. Hukuda and his associates. It has been revealed by them that the pattern of the postural blood pressure reflex was modified by fatigue and constitution of individuals. The present authors studied the change of various measures on the postural blood pressure reflex in healthy Japanese males and females ranging in ages from six to fifty-four years. The time for restoration of the brachial blood pressure after the change of posture decreases with age up to forties, while it increases somewhat above fifty. The irregular undulation of the blood pressure in the time course of restoration is more marked in children and the aged than adults. There was found no difference between males and females in the reflex pattern. It is revealed from the results that adjustment of the blood pressure to the postural change developed with advancing age up to forties but began to fail over fifty.
1. Infants with nutritional disturbance due to rice flour feeding were studied from the viewpoint of etiology of beriberi. As the result it became clear that those infants showing the symptoms of infantile beriberi had taken (i) a great quantity of so-called secondary carbohydrates, (ii) an extremely small quantity of primary carbohydrates i. e. sugars, and (iii) some quantity of vitamin B1. 2. Coli communior and Coli communis were cultured on protein-free media added with polished rice paste, and bacteria-free filtrate of the culture was found virulent to mice, when the pH of the media was on the alkaline side. Paralysis and heart dilation were observed in the mice injected with such culture filtrate. The effect was proportional to the duration of the culture. Cocci did not produce such poisonous material. 3. Similar cultures obtained without addition of polished rice paste did not produce such poison. 4. This poison was detoxicated by the liver to a certain extent. There were evidences that suggest vitamin B1 is a powerful detoxicating agent for this poison. 5. A working hypothesis of the authors on the 'nature of beriberi is formulated as follows: Unbalanced habitual eating of polished rice starch lowers the acidity of the intestinal content which allows proliferation of Con, group. When excessive amount of starch is taken in such individuals, it cannot be hydrolysed away, and the stagnant starch may represent suitable media for Coli communior or Coli communis to prodce a certain poisonous subtance, which, absorbed across the intestinal wall, causes beriberi. Antiberiberic action of vitamin B1 consists in detoxication. Briefly, the authors regard the beriberi as a intoxication instead of a deficiency disease.