Seasonal variations of mineral metabolism of calcium, magnesium, phosphor and nitrogen were examined for seven patients at a hospital and for 36 aged persons at a nursing home. Chemical analyses were made of food, feces and urine for 20 days period at the hospital and 5 days period at the nursing home in each season of summer and winter. And the balance between the intake and the excretion was compared between the two seasons. 1. As for calcium metabolism of the patients, the balance was higher in summer. And about the aged persons, both balance and storage seemed to be higher in summer. 2. Magnesium metabolism of the patients and also of the aged persons showed significantly higher level in summer from the view-points of the balance and the storage studies. 3. As for phosphorous metabolism, the patient group showed higher values in the balance and the storage in summer at the 5% level. However, the difference of these values of the aged persons between the two seasons did not reached to the significant level. 4. Nitrogen analyzed as an indication of protein metabolism showed positive balance in the two seasons for the hospital patients, and the storage rate was higher in summer with the significant level of 1%. For the asylum people the difference was not seen between the two seasons.
From the middle of August, 1968 to the end of February, 1969, alkaline ionized water (PH 10.2) was administered to 10 patients (500cc in a day for adults and less for children) every day for more than two months and to 20 patients for more than two weeks, with the following results. 1) The temperature showed a downward curve and the pulse showed a decreasing tendency. 2) As to the blood picture, both the number of erythrocytes and the amount of hemoglobin increased, and the blood making function was remarkable especially in anemic patients. 3) The blood pressure showed a descending tendency in patients of high pressure and an ascending tendency in patients of low pressure. As to the blood precipitation, a remarkable improvement was observed in one patient. 4) As to the liver function, no distinct tendency was observed because of lack of items and low frequency of measurement. 5) According to the gastrotest, control and improvement were observed in hyperacidity and hypoacidity respectively. 6) According to the examination of urine, glycosuria disappeared and albuminuria disappeared or lightened. 7) As to the result of medical treatment, remarkable or moderate effect was observed in 17 (85.0%) of 20 cases.
Silicosis poses a problem in the field of public welfare now. A member of reports indicate that silica causes arteriosclerosis. From the viewpoints of public hygiene, the author investigated the in vivo effects of silica taken by the oral route, namely by determining the quantity of silica contained in drinking water and its pattern of absorption in the living body. The results obtained were as follows : 1. Determinations were made on the quntities of silica containd in those drinking water samples collected in Kyogok Ucho, Hokkaido, in Tokyo-to, in Akiyama Muro, Yamanashi Prefecture, and in Gotenba City, Shizuoka Prefecture, with the result that apparent differences in the content of soluble silica were noted among the drinking water samples tested, In particular, the silica content of the drinking water sample collected in Kyogok Ucho, Hokkaido, was conspicuously high. 2. Each of the drinking water samples above indicated a high linear coefficient in the correlation between the soluble silica content (determined by means of the colorimetric silicomolybidate method) and the total silica content (determined by means of the gravimetric method). In the regression line, furthermore, these were significant differences noted among the drinking water samples tested. 3. In normal rabbits, a silicate (Na2SiO3) solution was immediately absorbed from the stomack and serum levels of SiO2 were increased. Also, its rapidly excretions into the urine were observed. 4. In normal rats, a silicate (Na2SiO3) solution was absorbed from the small intestines, particularly well from the duodenum. 5. Rats were given Na2SiO3 solution at dosages of 1mg. daily over a perioa of 25 weeks. They did not develop any differences from control rats in terms of the pattern of growth. Pathological findings on the artery were normal.