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Volume 14, Issue 4
Displaying 1-7 of 7 articles from this issue
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[in Japanese]1994 Volume 14 Issue 4 Pages 1-2
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (183K) -
Junichi HAYASHI, Katsuo AIZAWA1994 Volume 14 Issue 4 Pages 3-9
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPhotodynamic therapy and diagnosis mainly developed in the field of cancer research. With the advancement of laser science and laser equipments such as a diode laser, photobiology have been introduced into the cardiovascular field. Mono-L-aspartyl chlorin e6 (NPe6) is one of newly developed photosensitizers which overcame the first generation photosensitizer, hematoporphyrin derivative. NPe6 was recently applied for photodynamic treatment and diagnosis of the atheroma with good results. This article reviews new trends in photodynamic therapy and diagnosis for the atherosclerotic disease.View full abstractDownload PDF (841K) -
Hirofumi KAWABE, Takuzo OHTANI, Youzo FUKUDA, Tomohiro ISHII, Katsuo A ...1994 Volume 14 Issue 4 Pages 11-14
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPH-1126 was synthesized for photosensitizer using PDT.
Its photodynamic potensial was investigated as well as its uptake in transplanted tnmor.
Further, we demonstrated that PH-1126 possesed the photodynamic effect to transplanted tumor using the Kr+laser.
These results led to the following conclusion: 1) The accumulation of PH-1126 in tumor was 4.3μg/g at 48hour after administration (10mg/kg). 2) After PDT with Kr+laser (50mw/cm2, 60J/cm2) following administration of PH-1126 (10mg/kg), the tumor was disappeared.View full abstractDownload PDF (385K) -
Tetsu TAKENO, Tsuyoshi NISHISAKA, Ichiro OKURA1994 Volume 14 Issue 4 Pages 15-20
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWater-soluble zinc phthalocyanines substituted with different number of sulfonic acid groups were synthesized. ZnSPcmix was readily incorporated in HeLa cells. Irradiation of HeLa cells with ZnSPcmix resulted in cell damaged. The cellular morphological changes due to irradiation were observed using SEM.View full abstractDownload PDF (703K) -
Takeshi TAKEMURA, Susumu NAKAJIMA, Isao SAKATA1994 Volume 14 Issue 4 Pages 21-29
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSNew photodynamic therapeutic agents ATX-70, ATX-S10 and fluorescent diagnostic agent HAT-D01 for tumor have been discussed in terms of the photophysicochemical porperties, especially, the selective tumor affinity and photoreactivity.View full abstractDownload PDF (860K) -
Isao SAKATA, Susumu NAKAJIMA, Takeshi TAKEMURA1994 Volume 14 Issue 4 Pages 31-38
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSNew chlorin derivatives are synthesized via photoxidation from protoporphyrin dimethyl ester at 3 steps.
The resulting addition and condensation new chlorins have a strong absorption (ε>104) at longer wavelengths (>670nm) and good water-solubility, and the photosensitivity (dansyl methionine test) and the tumor affinity (albumin test) of them were satisfactory.
It is noteworthy that their photoxidations were concomitant with both type I and type II reaction mechanism. thus, new chlorins seem to be more useful for PDT.View full abstractDownload PDF (629K) -
1994 Volume 14 Issue 4 Pages 39-45
Published: 1994
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (10658K)
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