The Journal of Japan Society for Laser Surgery and Medicine
Online ISSN : 1881-1639
Print ISSN : 0288-6200
ISSN-L : 0288-6200
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Volume 19, Issue 3
Displaying 1-7 of 7 articles from this issue
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  • Photodynamic processes of cholesteryl oleate using IRFELs
    Yuko FUKAMI, Yoshihito MAEDA, Kunio AWAZU
    1998 Volume 19 Issue 3 Pages 123-130
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_123
    JOURNAL FREE ACCESS
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    Photodynamic processes induced by an infrared free electron laser (IRFEL) were examined by Raman spectroscopy and Fourier transform infrared microspectroscopy (FT-IR) for cholesteryl oleate which is specifically accumulated in the arteriosclerotic region on the arterial walls as a function of the FEL exposure time. We found that the exposure of 5.79μm-FELs induces not only dissociation of ester (RCOOR') bonds but also chemical changes of the ester (RCOOR') bonds to aldehyde (RCHO), carboxylic acid (RCOOH), carboxylate (RCOO-) or ketone (R2C=O) bonds.
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  • Fundamental study of lithotripsy with FEL
    -an expriment for bilirubin stone
    H. KAJIWARA, Y. SUMIYAMA, M. WATANABE, M. NAKAMURA, J. NAKAMURA, H. TA ...
    1998 Volume 19 Issue 3 Pages 131-138
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_131
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    Percutaneous transhepatic lithotripsy (PTCSL) has become the preferred approach in patients with biletract stones. On a basis of the current trend, we investigated early elimination of bilirubin stones using the latest free-electron laser (FEL).
    Infrared absorption spectra of gallstones that were removed surgically from the gallbladder and common bile duct were analyzed, and each absorbed dose was measured. The peak wavelength of absorption was at 5.75μm (wave number 1734cm-1).
    The experimental wavelength was settled at 5.75μm and 5.9μm (wave number 1695cm-1), and non-contact photoirradiation was performed with average outputs of the beam at 10mW, respectively. Photoirradiation at 5.75μm for 20seconds showed complete elimination of bilirubin stones, and no effects on surroundings were found, while photoirradiation at 5.9μm showed no response in treating bilirubin stones.
    Lithotripsy with FEL will be a useful treatment, since risks, such as recurrence due to remnant stones or damage to the duct wall, can be reduced.
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  • Ion irradiation-assisted specific immobilization of heparin on PSF by FEL illumination
    Y. HIBINO, G. C. XU, Y. SUZUKI, M. TANIHARA, Y. IMANISHI, K. AWAZU
    1998 Volume 19 Issue 3 Pages 139-147
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_139
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    Immobilization of heparin on polysulfone (PSF) was performed via Laser illumina-tion at wavelength of 6.18 micrometer, the typical absorption band of carboxyl group of heparin. This modification resulted in the surface hydrophilicity and resistance to adhesion o f platelets. Comparing the effects on virgin sample to the ion irradiated, the ion irradiated surface offered more suitablesites for the immobilization of heparin in the experimental range. This irradiation-assistant effect was probably raised from the broad adsorption band formed around laser wavelength after ion irradiation.
    The excited newly formed bonds reacts easily with the excited heparin molecules.
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  • FEL-induced Gene injection
    E. TAMIYA, K. AWAZU, N. NAGASHIO
    1998 Volume 19 Issue 3 Pages 149-153
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_149
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    The Free Electron Laser (FEL) has potential for various biomedical application due to its advantages such as flexible wavelength tunability, short pulse and high peak power. We could successfully introduced the PAN-7 plasmid DNA into E. coli DH5α strain by irradiation of 6.1μm FEL. 6.1μm-FEL irradiation was estimated to cause the selective ablation of biomolecules in cell membrane.
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  • Functional adaptation of skeletal muscle cells irradiated by a free electron laser
    Kunio AWAZU, Eiji NAKAMACHI
    1998 Volume 19 Issue 3 Pages 155-161
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_155
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    It is well known that muscles change their shape and strength by the mechanical stress. In this paper, tension test and compression test were done for skeletal muscle cells. We observed how a cell changed its direction. An infrared free electron laser was irradiated to skeletal muscle cells, and influence given to dynamic adaptation of a cell was examined.
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  • The Basis of Free Electron Laser in Medicine
    Kunio AWAZU
    1998 Volume 19 Issue 3 Pages 163-175
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_163
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    [in Japanese]
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  • [title in Japanese]
    1998 Volume 19 Issue 3 Pages 177-179
    Published: 1998
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.19.3_177
    JOURNAL FREE ACCESS
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