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Volume 34, Issue 4
Displaying 1-10 of 10 articles from this issue
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GENERAL ARTICLE
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Youkou Ohmaru, Koichi Ohmaru, Mina Ohyama, Kensuke Kiyokawa, Yumi Naga ...2014 Volume 34 Issue 4 Pages 367-371
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSSevere female infertility is almost always related to the malfunction of the ovaries. The use of assisted treatment of Assisted Reproductive Technology (ART) is important for overcoming infertility. Low reactive Level Laser Therapy (LLLT) has been shown to improve the blood circulation. A total of 337 females with severe infertility were treated with LLLT assisted for ART. Of these, 110 cases became pregnant and the fertility rate was 32.6% for patients receiving ART and LLLT. Compared with the conventional assisted treatment for ART, such as Chinese herbal medicine or melatonin, LLLT had almost the same treatment outcome. In the future, LLLT with the conventional assisted treatments may lead to an increased fertility rate for ART.View full abstractDownload PDF (1028K) -
Saki Nozoe, Norihiro Honda, Katsunori Ishii, Kunio Awazu2014 Volume 34 Issue 4 Pages 372-381
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSEndovenous laser ablation (EVLA) has become a minimally-invasive treatment of varicose veins. EVLA with the Japanese clinical trial was approved by the Japanese health and welfare ministry on January, 2011. However, there remain still some unsolved problems, such as pain and bruising of the treated vein. To our knowledge, there are few reports on the comparison of EVLA effects between the irradiation conditions to evaluate safety and efficacy quantitatively. The purpose of this study is to estimate the optimal irradiation conditions by ex vivo investigation. An ex vivo laser irradiation experiment was set up for various laser wavelengths, fiber types, and irradiation powers. The optical properties of samples were determined. Absorption coefficient of vein tissue at the wavelength of 1470 nm was 7 times larger than 980 nm. From the result of absorption coefficient, the laser with a wavelength at 1470 nm is more efficiency than the laser with a wavelength at 980 nm. A 2ring fiber gives rise to a sufficiently high shrinkage rate with less variability at each laser power. From the results of histological analysis, extensive necrosis from the tunica intima to tunica externa due to laser irradiation was observed. EVLA with a laser wavelength of 1470 nm and a 2ring fiber offers advantages.View full abstractDownload PDF (1932K)
TOPICAL ARTICLE: Current state in low reactive level laser therapy
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[in Japanese]2014 Volume 34 Issue 4 Pages 382-383
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSDownload PDF (373K) -
Toshihiro Kushibiki, Takeshi Hirasawa, Shinpei Okawa, Miya Ishihara2014 Volume 34 Issue 4 Pages 384-393
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSLow reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty decades, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term “low reactive level laser therapy (LLLT)” has become widely recognized. In this review, we will describe the mechanisms of action of LLLT at a cellular level. Finally, our recent research results that LLLT enhanced the cells differentiation will also be described.View full abstractDownload PDF (1044K) -
Toshihiro Kushibiki, Shinpei Okawa, Takeshi Hirasawa, Miya Ishihara2014 Volume 34 Issue 4 Pages 394-401
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSIn this review, we introduce the recent developments of optogenetics, novel methods for controlling gene expression, cell morphology and signaling pathways by using the light technology and genetic engineering. The channelrhodopsins, LOV (light oxygen voltage) domain, and these applications are described. The optogenetics is maturing towards elaborate applications in basic research, in the production of biopharmaceuticals and in biomedicine.View full abstractDownload PDF (1237K) -
Masanori Yamato, Akira Kaneda, Yosky Kataoka2014 Volume 34 Issue 4 Pages 402-405
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSWe demonstrated the anti-inflammatory effect of daily external low-reactive level laser irradiation (LLLI) in an animal model of crescentic glomerulonephritis. Crescentic glomerulonephritis was induced in rats by intravenous injection of antibody for glomerular basement membrane (GBM). The rats were irradiated with a low-reactive level diode laser with an infrared wavelength of 830 nm from the shaved skin surface once a day for 14 days (irradiation spot size on the skin surface, 2.27 cm2; power intensity, 880 mW/cm2; irradiation mode, continuous mode; irradiation time, 250 s; energy, 500 J; energy density, 220 J/cm2). After laser irradiation for 14 days, the kidneys were taken, and the extent of inflammation was evaluated. LLLI showed anti-inflammatory effect on the renal tissue.View full abstractDownload PDF (926K) -
Hiroshi Ueno, Keita Fukazawa, Akiho Harada, Toyoshi Hosokawa2014 Volume 34 Issue 4 Pages 406-412
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSThe diabetic neuropathy is the most frequent complication in diabetic patients, and the neuropathic pain and numbness of the limbs tip are the main symptom. It is thought that the essential mechanisms of the neuropathy are the direct neuronal damage, the nerve damage due to perineural vascular disorder, and a neurologic reproduction disorder by the hyperglycemia. As for the treatment of the neurologic symptom, drug therapy with an aldose reductase inhibitor and the analgesic adjuvant is first-line. Moreover, the effectiveness of the treatment by the low reaction level laser irradiation therapy with vasodilatation action and nerve regeneration action has been confirmed.View full abstractDownload PDF (1350K) -
Kenji Yoshida2014 Volume 34 Issue 4 Pages 413-421
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSLow reactive Level Laser Therapy (LLLT) has become a widespread method of the non-invasive treatment for accelerated wound healing, pain control, biostimulation and other beneficial applications. Its efficacy and evidence are already reported by the systematic review and meta-analysis in the literature. Recently the new concept of “ Low reactive Level Light Therapy ” has been proposed and has become acceptable. The “Light” includes not only the lasers but also LEDs (Light-emitting diodes) and other sources. On the basis of this concept, new phototherapy equipment has been developed in clinical use. In the field of dental and oral surgery, LLLT (i.e., laser therapy) has been applied in many areas such as the reduction of oral mucosititis, orthodontic treatment, pain control of temporomandibular joint dysfunction and many others. This review article presents the current state of research into LLLT in the field of dental and oral surgery.View full abstractDownload PDF (1105K) -
Hideko Arita, Jitsu Kato, Setsuro Ogawa, Kazuo Hanaoka2014 Volume 34 Issue 4 Pages 422-428
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSAs society ages, the number of patients with chronic pain keeps increasing at a rapid rate. In addition to the main treatment methods at a pain clinic including nerve blocks and pharmacotherapy, light therapy is indispensable as well. It is efficacy, however, has not been so clear as nerve block. In the present study, the intensities of pain in patients with chronic pain before and after a session of light therapy were measured using the visual analogue scale and the degree of pain to confirm the efficacy of light therapy. The study also discusses how to interpret intensity of pain complained by patients concerning two diseases.View full abstractDownload PDF (909K) -
Haruna Sugawara, Keiko Iwamoto, Yurika Kotani, Keiko Ono, Kaho Kurosak ...2014 Volume 34 Issue 4 Pages 429-435
Published: March 15, 2014
Released on J-STAGE: April 16, 2015
JOURNAL FREE ACCESSIt has been reported that low-power laser irradiation (LLI) can modulate various biological processes including the cell proliferation. However, mechanisms underlying the LLI effects remain unclear. We have demonstrated the following effects using three types of LLIs: The blue 405 nm LLI caused the human-derived glioblastoma (A-172) to the cell death, green 532 nm LLI significantly promoted the cell proliferation, and near-infrared 808 nm LLI potentially suppressed the cell proliferation. To reveal the mechanism of wavelength-specific LLI effects, the present study was designed to examine those LLI effects with focusing on mitochondrial morphology. 532 nm LLI significantly increased a small and granule type of mitochondria while decreased a large fusion type of them, compared with those of control (non-LLI) group. In contrast, 808 nm LLI significantly decreased the former type of mitochondria while increased the latter type. In the case of 405 nm LLI application, it induced live (spindle-type) cells and also apoptotic (round-type) cells. Mitochondrial morphology in the spindle-type of cells showed almost the same tendency as 532 nm case. We conclude that the wavelength-specific LLI effects are based on the mitochondrial morphological changes.View full abstractDownload PDF (1234K)
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