In view of the fact that bile or biliary acid enhances the absorption of calcium from large intestine, thus extremely increases the calcium content in the blood causing acute intoxication death of rabbit, the author believed that, if the absorption of calcium is enhanced by substances other than bile or biliary acids, it will be of extreme significance in the elucidation of the absorption mechanism, and he also presumed that it will further clarify the calcium absorption enhancing activity of bile or biliary acid in the large intestine. Hence he attempted the following experiments.
In the first place, glycocoll and taurin as amino acids, which are presumed to be easily absorbed from the large intestine when administered alone as enema, glucose and sucrose as sugars, peptone and gelatin and starch as substances hardly absorbed, were selected and each of them was administered respectively combined with calcium preparation as enema. In addition, blood pressure and respiration rate were observed in order to note the effect of the enhanced 'calcium absorption from the large intestine on the circulatory system of the rabbits.
1) In the cases of glucose, sucrose or starch solution given alone as enema, no significant change of calcium content in the serum was observed.
2) In the case of glucose combined with calcium chloride, the calcium content in the serum extremely increased indicating the enhanced absorption of calciu.n from the large intestine. The enhanced absorption of calcium sulfate or calcium lactate were not clearly noted.
3) In the case of sucrose combined : with calcium chloride, calcium content in the serum was increased when a highly concentrated solution of sucrose was used. Absorption of calcium sulfate or calcium lactate were generally not affected.
4) In the case of starch combined with calcium chloride, the calcium content in the serum was distinctly increased and intoxication symptoms were observed in the rabbits. The absorption of calcium sulfate or calcium lactate were almost not affected.
5) In the case of glycocoll combined with calcium chloride, the calcium content in the serum was extremely increased, and intoxication death was also noted. The absorption of calcium sulfate was not affected, but that of calcium lactate was enhanced.
6) In the case of taurin combined with calcium chloride, the calcium content in the serum was increased, and intoxication symptoms and intoxication death were also observed. The absorption of calcium sulfate and calcium lactate were not affected.
7) In the case of peptone combined with calcium chloride, the calcium content in the serum was increased and intoxication death was also observed. The absorption of calcium sulfated and calcium lactate were almost not affected.
8) In the case of gelatin combined with calcium chloride, gelatin did not clearly affect the absorption of calcium from the large intestine.
9) when calcium preparation combined with the mixture of glycocoll and glucose was administered as enema, the absorption of calcium chloride as well as of calcium sulfate and calcium lactate were remarkably enhanced, and intoxication death of rabbits were also frequently observed.
10) AA remarkable lowering of blood pressure was caused by the administration of calcium chloride combined with glucose or glycocoll as enema. Further, in the case of the mixture of glucose and glycocoll combined with calcium chloride, the blood pressure was remarkably lowered, and the respiration rate was also decreased in he course of time.
In short, the acute intoxication death seen in rabbits when calcium preparation combined with amino acids or glucose was administered as enema, is considered to be induced by rapid absorption of calcium from the large intestine followed by the remarkable lowering of blood pressure. Further, the absorption of amino acid and glucose, which were administered in combination, was also considered to be enhanced.
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