昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
16 巻, 1 号
選択された号の論文の8件中1~8を表示しています
  • 木島 博保
    1956 年 16 巻 1 号 p. 1-7
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    A strain of mutabile type (M) variant was obtained from each of the 3 strains of E. coli. When these M variants were cultivated in galactose peptone (GP) water, they were divided into 3 groups: (a) difficult to produce galactose fermenting daughter type variant (RT), (b) relatively easily produce them and (c) very easily produce them. Employing the last one, the author investigated as to whether the RT variant is derived from M variant or from daughter mutabile type (MT) variant. The results thus obtained revealed that RT variant is derived from M variant. When the above stated 3 strains of M variant were cultivated on galactose casamino medium containing B. T. B., which is extremely inhibitory to the growth of M variant, yellow colonies grew on the plate in addition to those of MT variant. This yellow growth was proved to be what Fukutome and his co-workers have named RT variant. The rate of appearance of RT variant was found related to the degree of the fermentation of GP water by M variant, The number of colonies of RT was in proportion to the bacterial number of the inoculum. For instance, when the bacterial concentration of the 10-3 dilution of M variant suspension was at the order of 100, 000 per cc, several colonies of RT variant appeared. In other words, RT variant appeared at the rate of 1/100, 000 of the bacterial number of M variant. When the dilution was more than 10-4, RT variant hardly appeared. Furthermore, the number of colonies appeared was not found increased according to the lapse of incubation period. Reviewing the results of the present work, the author found that his findings well coincide with the observations by Ushiba and his co-workers on MT variant, excepting that the rate of mutation differs according to varying strains. Generally, in most cases, the rate was much lower compared with that of the mutation to MT variant. This problem will be further investigated in a later report.
  • 木島 博保
    1956 年 16 巻 1 号 p. 8-14
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    When the mutabile type variant of E. coli (Murase) was cultivated on the medium containing galactose, galactose fermenting daughter type variant (RT) grew beside Murase's daughter type mutabile variant (MT) . Consequently, a series of experiments were conducted by the author on the carbohydrate fermentation, various reactions, findings on tcolonies, comparisons in S-R, re-mutability, immunological properties and the comparison with MT variant and RT variant. When RT variant was compared with the original strain, M variant and MT variant, it was found to be most closely resembling to the original strain. Furthermore, it was derived from M variant which possesses different properties from the original strain. When this RT variant was cultivated in the broth for a long period of time, M variant appeared again, and the pattern of the appearance was found quite closely resembling to the case of the original strain being almost indistinguishable from each other. It is needless to state that MT and RT variants appeared again from this M variant. These M, MT and RT variants were all indistinguishable from those derived from the M variant of the original strain. Consequently, it apparently looked like a cyclic mutation phenomenon showing a revert of M variant to the original strain which again produce M variant. However, this problem is still under further investigations.
  • 矢部 祐一
    1956 年 16 巻 1 号 p. 15-32
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    As to the fate of cocaine in the living subject, many points are still considered not necessarily clear. The author attempted the reinvestigation relative to the toxicity and excretion of cocaine employing animals in embryonal stage, i.e. chick embryo, which are different in nature from those hitherto employed in the similar attempts.
    The influence of cocaine on the general development of chick embryo was first investigated, and the histological investigation on the liver of the embryo were then performed. Furthermore, the pattern of the excretion of cocaine into the allantoic fluid and the hydrolysis of cocaine by liver extract were also investigated, thereby the author attempted to help clarification of the fate of cocaine in the living subject. The followings are the results thus obtained.
    (1) The development of the chick embryo from eggs which received cocaine was, found inhibited when compared with that from the control eggs. Specifically, the inhibition was found eminent in proportion to the concentration of cocaine given.
    (2) In the cases where 5 mg or 10 mg of cocaine was given, mulformations were recognized in the chick embryo, and in all cases where 20 mg of cocaine was given, the chick embryos were found dead.
    (3) More favorable development was observed in the cases tested during the summer when compared with those tested during the winter.
    (4) The histopathological changes in the liver of the chick embryo, which receivedd cocaine, became stronger in proportion to the concentration of cocaine. Such changes were found specifically stronger in the latter half of the incubation period compared with the first half.
    (5) The excretion of cocaine into the allantoic fluid was found extremely minute, and the major part of cocaine is hydrolysed within the egg or the body of the chick embryo.
    (6) Cocaine is hydrolysed by the liver extract of chick embryo, and the inactivation by the liver extract from the chick embryo, which received cocaine, was foundd stronger compared with that from the controls.
  • 角尾 滋, 関谷 雄孝, 室塚 英夫, 相沢 廉, 中村 倫彬, 長谷川 圭吾, 宮下 幸夫
    1956 年 16 巻 1 号 p. 33-43
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    The author investigated the influences of Cytochrome-C on the general development and various metabolisms of the chick embryo by giving Cytochrome-C to developing hen's eggs. The present work is divided into two parts. In the Exp. (I), the drug was administered prior to the incubation, and in the Exp. (II), the drug was administered on the 5 th day of incubation. The followings are the results thus obtained.
    (1) In both of the Exp. (I) and Exp. (II), no systematic influences on the general development of the chick embryo were found exercised by the administration of Cytochrome-C.
    (2) The Pyruvic acid contents in the allantoic fluid in the latter half of the incubation in the case treated with 300γ and on the 15 th day of incubation in the case treated with 600γ of Cytochrome-C in the Exp. (I) were evidently larger compared with those of the control eggs.
    (3) The N-contents in the allantoic fluid in the cases treated with 300γ and 600γ of Cytochrome-C in the Exp. (I) were larger compared with those of the control eggs on the 12 th and 15 th day of incubation. In the Exp. (II), in the first half of the incubation period of the cases treated with 300γ of Cytochrome-C and on the 12 th and 18 th day of incubation in the cases treated with 600γ of Cytochrome-C, the N-contents in the allantoic fluid were found larger compared with the control.
    (4) The Vitamin B1 contents in the allantoic fluid were investigated only in the Exp. (II) . They were found larger compared with the control on the 15 th day of incubation in both of the cases treated with 300γ and 600γ of Cytochrome-C.
  • 角尾 滋, 関谷 雄孝, 室塚 英夫, 相沢 廉, 長谷川 圭吾, 中村 倫彬, 宮下 幸夫
    1956 年 16 巻 1 号 p. 44-49
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    In their first report, the authors investigated the influences of the single administration of cytochrome-C on the general development and various metabolism of chick embryo. In the present work, however, the authors investigated the actions of the combined administration of cytochrome-C on various metabolic anomalies in chick embryo induced by the pre-incubation administration of Pentobarbital-Na. The following is the results thus obtained.
    No systematic differences in the metabolism of N or Vitamin B1 were observed between the groups of eggs treated with single Pentobarbital-Na and those with Pentobarbital-Na combined with cytochrome-C. The Pyruvic acid content in the allantoic fluid in the group treated with combined administration was lower in concentration and more scanty in quantity compared with the single administration during the whole period of incubation, excepting on the 9 th day of incubation.
  • 市原 正雄
    1956 年 16 巻 1 号 p. 50-52
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    Chronic sinuitis posses various specificities, which cannot be observed in other diseases. Moreover, in certain instances, it occurs possibly through extremely complicated processes. Therefore, the author considers it essential to find out a suitable treatment case by case, in addition to the thorough performance of various examinations considering its psychological effects simultaneously.
  • 三浦 栄太郎, 原田 直孝, 和田 俊輝
    1956 年 16 巻 1 号 p. 53-57
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
    1. The present paper is an autopsy report on a 53 years old female, who has died under the diagnosis of gangraenous progressive rhinitis after a clinical history covering a period of an approximately 1 year.
    2. Considering the entity of the present disease, there are two possible explanations : infection and tumor. The present case is assumed as a sort of tumorous lesion which would have derived from an osteogenenic tumor, probably atypical myeloma.
    3. Bacillus proteus and Staphylococcus aureus have been detected from the nasal focus by bacteriological procedures.
  • 野口 英世, 荒井 十三男, 柳沢 裕, 中村 暁史, 唐沢 洋一, 佐川 文明, 浅利 周美夫, 三宅 正高, 中沢 進, 沼尾 欣一, ...
    1956 年 16 巻 1 号 p. 58-59
    発行日: 1956/03/30
    公開日: 2010/09/09
    ジャーナル フリー
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