A case, seventeen-years old male, was suspected on benign tumor of lung by X-ray examination. The case was reported because of rarity of such a large carnification found in lung and of its histological picture showing a transition form between epithelioidcell granuloma and giant-cell granuloma.
The ophthalmic examination was performed in Kotsubo Village, Zushi City on July 26 and 27, 1958. Then trachoma was investigated in Kotsubo Primary School and the following results were obtained: 1) The subjects were 116 boys, 43.7±3.1% of all pupils, 159 girls, 62.1±3.0% and 275, 52.7±2.1%, in total. 2) Infection rate: Boys were 5 (4.3±1.8%), girls 16 (10.0±2.0%), and 21 (7.6±2.5%) in total. 3) Infection rate by school years: The sixth-year pupils were 11 (13.9±4.1%), fifth-year 6 (13.0±5.2%), second-year 2 (8.0±5.1%), first- and fourth-year 1 and thirdyear 0. respectively 4) Distribution by stages: Thirteen pupils (62%) was in the I stage, 2 (9.5%) in II and 6 (28.5%) in III.
The etiology of infantile anal fistula is quite different from that of adult because the anus is still developing. It is (1) a subcutaneous fistula around the sphincter, (2) found always bilaterally and (3) more frequently in boys. It seems to be caused by the pressure of feces put to the narrow sphincter with incomplete contractibility. As the anus is moistened by evacuation all the time, there are often apt to be subjected to recurrences. No detailed report on its treatment have appeared since Ikeuchi's in 1953. This paper deals with two cases of infantile anal fistula successfully treated by small incision combined with antibiotics.
The inhibition of growth in chick embryo and the damage in their liver were observed by the administration of 1-methyl-2-mercaptoimidazole (Mercazole) to the fertile white leghorn eggs. The significance of struma parenchymatosa diffusa was noticed histopathologically in the thyroid of the chick embryo by the administration of Mercazole. I131 uptake-ratio in the entire thyroid was increased while its uptake per 1mg of the thyroid was decreased.
1. The development of specific and nonspecific cholinesterase (ChE) has been studied manometorically in brain and liver of the human fetus and the chick as their specific sub-strates, using Acetylcholine, Acetyl-β-Methylcholine and Benzoylcholine. 2. Specific ChE activity increased during the antenatal development in the human fetus, however, it decreased during the postnatal development in the chick brain. 3. Nonspecific ChE activity increased during the antenatal development in the human fetus and the postnatal development in the chick liver. 4. These two enzymes were completely different in character, and the pattern of their development was also quite different.
1) The syphilis were found in about 12% among people who were subjected to examination. 2) The syphilis positive ratios were as follows. O-group is 10% ( _??_: _??_≅2: 1), A-group is about 10% ( _??_: _??_≅ 2: 1), B-group is 15% ( _??_: _??_≅1: 1), AB-group is 13% ( _??_: ≅5: 1) . 3) The syphilis positive rate: The rate of the most sensitive syphilitic reaction is: Objectglass- : Murata's- : Ogata's- Method. ≅2: 1: 1. 4) It is inferred that those syphilis reactions have no effect on OAB-blood groups.
It is well known that facilitation or inhibition in spinal reflex occured usually which shows the participation of wide region of the spinal cord in the single spinal reflx. In this experiment, the upper parts of the spinal cord of Bufo ulgaris or Rana nigromaculata were disected, and the reflex discharges were tested at the ventral root of lower segment. It was elucidated that the reflex discharges were strengthened or weakened following disection of the spinal cord. The strength of facilitation or inhibition appeared in the reflex were changed occording to the position of disection in the spiel cord. From these facts, it was concluded that interneurons which took part in the facilitation or inhibition, distributed in wide region in the entire spinal cord.
M-type variants (Murase) were isolated from the strain 396 of Salm. enteritidis by old broth culture method. Strain mt1, was isolated from the daughter colony of M type variant, strain mt2 was isolated from that of mt1 and strain mt3 was isolated from that of mt2. Strain mt4 was isolated from the tube of mt3 cultured in galactose peptone water for one week and failed to ferment it. Galactose sensitivity of those mt strains was investigated by the paper disk method. Those which have demonstrated full resistance to galactose were called MT. As for mode of the acquisition of resistance, it can be said there are two ways that some acquire full resistance by a single step and the others by several steps. Generally speaking, the acquistion of galactose resistance by mt strains seem to belong to the streptomycin type of Demerec. With regard to antibotics, it is highly difficult to develope sensible strains by the use of an excessively high concentration. While, in the present study, in spite of the use of galactose in such a high concentration of 5, 000γ/cc, both sensible M-type variants and resistant daughter mt can grow on it. Some of the deep-cultured colonies were found to consist of full resistant bacteria. In case of antibiotics, sensible strains are wild strains and resistant ones are those which likely developed variation in some charactors. On the other hand, galactose sensible strains discussed in the prepent study are variants at the beginning and the resistant strains are rather those reversing to the original from it. Accordingly, it can be said that similar acquisition of resistance was confirmed to follow the variation to reverse direction suggesting the presence of some rules in the hereditary processes related with the acquisition of resistance to the other chemical agents.
Daughter strains with increasing galactose resistance were isolated from the M-type variant of Salm. eteritidis (strain 396) by daughter colony producing method through the cultivation on galactose-Endo plates. They were named as mtl, mt2, mt3, mt4 and the details of which were already reported in the previous paper. Each of the mt strains was. subjected to the dilution culture in galactose broth. As the result of the present investigation, galactose weakly fermenting WRT of Yamamoto, were isolated from the cultures of MT-like colonies. Exceptionally, RT of Fukutome et al. was also isolated on some occasions. Mucoid variant mtl was newly isolated from one of the mt1 strains and the WRT which was derived from the mucoid variant was not seemd mucoid. Distinguished difference were observed between mt and WRT group in the oxgen. consumption which was measured by warburg's apparatus. Strain mt's showed the similar biological characters to the original. Most of mt1 strains, like the variant of M-type, were highly susceptible to galactose and lactose. WRT was different from mt's on the point that it ferments galactose.
1) Stock cultured strain of Mycobacterium tuberculosis var, homnis was isolated from sputum. The sensitive or resistant strain to INH, were treated with 4% NaOH and then inoculated on the media containing 3% KH2PO4. The number of colonies observed was not related to the sensitivity or the grade of resistance of the strains. The same result was obtained in case of 4% H2SO4 treatment, but their population increased when the latter treatment was employed. 2) The strains and sputum were treated with 4% NaOH and were inoculated on the pyruvic acid containing media and the modified III Kirchner agar media. The colonial populations on pyruvic acid containing media were generally greater than those on 3% KH2PO4 media. The populations on the modified Kirchner agar media were about the same as those on 3% KH2PO4 media.
1) The resistivity to INH of the INH resistant bacteria which isolated from sputum were examined in several generation. Their resistivity varied. 2) INH resistant strains and sputum were used. They were inoculated directly or after neutralization of the sputum or the treatment with 4% NaOH or 4% H2SO4 on the INH resistance testing media, consisted of 1% KH2PO4 media, 3% KH2PO4 media and 3% Na2HPO4 media. The highest resistance values were obtained on 3% Na2HPO4 (pH after inoculation: 6.8) . 3) The sputum was inoculated on the resistance testing media, consisted of 1% KH2PO4 media, 3% KH2PO4 media and 3% Na2HPO4 media. The resistance decreased in the order of 1% KH2PO4 media (pH 7.0), 3% KH2PO4 media (pH 6.4) and 3% Na2HPO4 media (pH 7.9) . 4) The sputum was cultured on resistance testing media, consisted of 3% KH2PO4 media and modifyed III Kirchner agar media. The higher resistance values were obtained on the modifyed III Kirchner agar media. Non of the strains with the highest resistance grew only in the modifyed Kirchner media.
1) A correlation between catalase and peroxidase reaction was found. 2) Either of two reactions was negative in 100γ and negative or positive in 10γ and 1γ resistant strains. Sensitive strains and 0.1γ resistant strains exhibited positive response. 3) Slight variations were noted in catalase reaction after transfers or the treatment with 4% NaOH. Some of the positive strains changed to negative, but negative strains remained negative. 4) The differentiation between resistant and sensitive strains in their mixed cultures could be done by means of catalase reaction.
1) Two cases of calcifying epithelioma developed in the subcutaneous tissue of the left forearm of a 21 yr. old female in the course of 6 years and the right thigh of a 29 yr. old male with a clinical course of 3 years have been observed. 2) Different symptoms were observed in the same disease with the difference in the length of period of clinical course. 3) Discussion was made on the ossification of calcifying epithelioma, bone formation in skin and osteoma cutis, and it was stressed that ossification should be considered as a feature of calcifying epithelioma.
According to Henschen, 53.5% of brain tumors are glioma (spongioblastoma, astrocytoma, oligodendroglioma and glioblastoma) . Two cases brain tumor were autopsied. Case 1. 45 yr. old male. The patient complained of headache, turbidity of conscious-ness and paralysis of the right facial nerve since December, 1955. Attacks of convulsions and loss of consciousness occured repeatedly and he died in June, 1956. A diagnosis of oligodendroglioma (rather undifferntiated) was made following the autopsy. Case 2. 37 yr. old female. The patient complained of amnesia, headache, disturbance of sight and obesity since November, 1955. She died in February of the following year. Histologically, glioblastoma multiforme with transitional figures to neuroblastoma was confirmed.