昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
19 巻, 8 号
選択された号の論文の9件中1~9を表示しています
  • 杉山 規矩夫, 高塩 昭三, 鍾 肇禎, 永根 純一, 久木田 正夫, 高橋 敦, 佐川 文明, 田中 利明
    1959 年 19 巻 8 号 p. 719-722
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    Described herein are the findings of an autopsy case of hepatoma, male, 48 years old. The liuer of this case measured 7, 500 grams in weight which was the second heaviest hepatoma hitherto discovered in Japan. The heaviest hepatoma was 9, 000 grams.
  • 村井 敬爾, 高松 保, 市原 正雄
    1959 年 19 巻 8 号 p. 723-731
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    1. The multiple occurrence of an eruptive and febrile infectious disease among the employees in a dormitory of a certain factory was diagnosed as Izumi fever in view of the epidemiological evidences as well as clinical and laboratory findings. The angina observed on these patients was provisionally called as Izumi fever angina.
    2. Tonsils of the patients of Izumi fever demonstrated the mixed infection of Streptococcus, and Staphylococcus (one with hemolytic streptococcus) being highly swollen and enlarged with fairly strong erythema. This angina was milder than that of scarlet fever but stronger than thatt of lacuner tonsillitis.
    3. The patients responded well to the treatment with Mycillin. The two tonsils enlargedd as far as almost to touch each other on the median line diminished in size to a degree not toexceed the posterior palate within a month.
    4. As it was stated by Ueda on scarlet fever, tonsillectomy is also believed to be of considerable value in the treatment of Izumi fever though it is too early to draw any decisiveconclusion.
  • 川崎 猛
    1959 年 19 巻 8 号 p. 732-745
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    Four kinds of sulfa drugs, namely, Sulf aisoxazole, Sulfisomidine, Sulf anilylbutylurea and Acetylsulf aisoxazole were administered to rabbits orally or rectally and their blood levels were determined 6 hours following administration in order to know the state of their absorption from the G. I. tract. Furthermore, the influence of starch sodium-glycolate and sodium-polyacrylate given in combination with the above mentioned sulfa drugs was also investigated. A separate experiment was undertaken on rats concerning with the toxicity of the latter substances.
    The results obtained showed that on single oral administration the absorption of Sulfaisoxazole was the best and on rectal application Sulfanilylbutylurea was the best among the 4 sulfa drugs tested. While, the influence of 2 substances used in combination with sulfa drugs was inconsistent partly enhancing and partly inhibiting the absorption of sulfa drugs.
    No appreciable toxicity in the dosage used of sodium-polyacrylate was observed on the rabbits of the present study.
  • 入江 棟一
    1959 年 19 巻 8 号 p. 746-756
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    Changes produced in the excitability of muscle fibers were investigated by the use of the sartoris muscle of Bufo vulgaris fixed in a separating box, comparisons being made between the two kinds of V-t curves, namely, one obtained by the stimulation of the aneural portion and the other obtained when the transmission of impulse from the nerve to the muscle had been disconnected by the effect of end-plate blocking agents such as d-tubocurarine or procaine.
    Besides, records of the end-plate potential and the accompanied action potential of the muscle were taken when the end-plate blocking was incomplete.
    As the result of this investigation, this author could elucidate that there exists the relationship of the empirical formula of Weiss between the end-plate potential and the time elapsed from the appearance of the end-plate potential to the appearance of the action potential of the muscle and could offer an experimental support to the theory to say that the stimulation of the muscle by the local current caused by the end-plated potential is the last stage of the impulse transmission at the end-plate. In addition, the V-t curve determined after application of the blocking agent was found to shift upward proving that the excitability of the muscle itself is lowered by the application of the blocking agent.
    When CaCl2 is applied on the muscle, the end-plate potential becomes extremely high while the impulse transmission becomes greatly disturbed. This fact was also proved experimentally to be due to the lewering of the excitability of the muscle fiber by the presence of an excessive amount of CaCl2.
    In view of the findings stated above, it was concluded that a part of the mechanisms of the end-plate blocking agent is undoubtedly due to the lowering of the end-plate potential but the lowering of the excitability of the muscle fiber itself is also playing an important role in the appearance of the blocking effect of the end-plate blocking agent.
  • 本西 キミコ
    1959 年 19 巻 8 号 p. 757-775
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    An optimal dose of 1-allyl-3-ethyl-6-aminotetrahydropyrimidinedione causes a diuretic action on chick embryos comparable to the one observed on adult animals. Its mode of action is the inhibition of the reabsorption of Na in the renal tubules. It, however, fails to show any distinct reparative action against the abnormal retention of water induced on chick embryos by the administration of Nicotine.
  • 旗手 敏, 溝口 一枝
    1959 年 19 巻 8 号 p. 776-778
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    Divided frontal sinus is almost a constant finding in the dog, while this is quite rart (3-6%) in human. In the dog, the four frontal cells are formed successively in the order : the third, the second and the first sini, the sini being numbered from the ventral to the dorsal side. In human, , on the other hand, they are formed in the order : the first, the second and the third sini.
    In the dog, the concha f rontalis enters into the entrance of the divided frontal sinus, turning and winding with each other, namely, it is oriented outward in the third sinus and inward in the second sinus.
  • 松田 弘
    1959 年 19 巻 8 号 p. 779-795
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    The grandular stomach of animals, especially that of rats and mice, has been found to be highly resistant to the action of known carcinogenetic substances without yielding the development of carcinoma.
    Considering the fact that there are a large number of gastric cancer originated from gastric ulcer in Japan, The author thought that it might be possible to expect some change in the susceptibility of the mucous membrane of the glandular stomach of mice or rats if chronic ulcer had previously been produced.
    In this connection, the method of producing chronic ulcer was studied. Mice were found to be inadequate for this purpose and the best method found with rats was to inject 0.1 ml of 20 % caustic silver solution into the submucous layer of the stomach by laparotomy. This method gave the best survival rate with the highest rate of ulcer formation.
    Rats thus treated to produce ulcer were administered with a daily dose of 2 mg of 20-methylcholanthrenene dissolved in drinking water. This substance was first. dissolved in polyethylenglycol to be rendered water-soluble and then tap water was added. Only the rats fed on this water more than 20 days were subjected to the present study.
    A total of 52 rats became available and marked heterotopic metaplasia of the mucous membrane was seen in 6 cases, atypical metaplasia in 6 cases and intestinal epithelial metaplasia in 6 cases. All of these lesions are commonly observed on the stomach of human gastric cancer. Development of gastric cancer, however, was not recognized. Control animals, moreover, showed no such lesions.
    This experiment was not successful in developing gastric cancer, but all lesions mentioned above were detected only on the lesions or scars of experimentally produced ulcer suggesting that the mucous membrane of those parts have shown a considerable reaction against the influence of carcinogenetic substances.
    In order to facilitate the development of gastric cancer, therefore, this method should be tried when undertaking similar experiments employing other kinds of laboratory animals, carcinogenetic substances or the solvents.
  • 高杉 敏太郎
    1959 年 19 巻 8 号 p. 796-823
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
    The administration of Vitamin B12 to the incubating fertile eggs caused no marked toxic effect, but an evident diuretic action.
    The effect on the toxicity of Nicotine by the changes produced in the morality rate, growth of embryos and the metabolism of water, electrolytes and vitamin B1 was examined by the combined administration of Nicotine and vitamin B12. Development of Nicotine hydrops was not inhibited in this experiment indicating that vitamin B12 has little counter action against the toxic effect of Nicotine.
  • 新谷 博一, 成沢 達郎, 井上 康平, 河野 徹, 石丸 寛, 山本 常市, 市原 正雄, 宮尾 赴, 小松 晃, 神尾 鋭, 白倉 賢三 ...
    1959 年 19 巻 8 号 p. 824-826
    発行日: 1959/10/30
    公開日: 2010/09/09
    ジャーナル フリー
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