昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
20 巻, 6 号
選択された号の論文の15件中1~15を表示しています
  • 藤井 吉助, 外山 順一, 村田 晴方, 松江 清平
    1960 年 20 巻 6 号 p. 533-536
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    A new antalgic and sedative injection “Dedoran” is a product consists chiefly of Adorum-Aminopylin compound (80 mg) in combination with Hilaamin-HCl (15 mg), Promethazin-HCl (6 mg), and Aminopylin (40 mg) . Stated in the following are the findings of its clinical application :
    1. Basal anesthesia before operation : One injection of Dedoran was given 30 minutes before operation. The injection was effecteve in 5 out of the 7 cases received injection and not effective in 1 case. In all cases, there was no appreciable effect on the blood pressure.
    2. Postoperative pain : Injections were given after the patients begun to complain of pain. The injection was effective in 4 out of 6 cases received injection. No influence was recognized on the blood pressure.
    3. Pain in the terminal stage of the cancer of cervix : The injection was effective in 2 out of the 3 cases received injection. Duration of the effective period was long and the antalgic effect was excellent.
    4. Anesthesia for the endometrial curette and artificial abortion : In combination with the topical anesthesia by Procaine, Dedoran showed a considerable antalgic effect against the pain at the time of cervical opening, contraction of the uterus. and also the postoperative pain. Namely, the injection was effective in 19 out of the 20 cases received injection. It was not effective in only 1 case. In 1 case, erythema, swelling and pain were observed at the site of injection.
  • 渡辺 五郎, 神田 実喜男, 芝木 武雄, 高尾 利夫, 大野 嘉郎, 田原 敬三, 鴇沢 正, 大森 進, 牧野 康三, 原 小一
    1960 年 20 巻 6 号 p. 537-543
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    1. An investigation was made on 9 cases of neuroblastoma from 4 months to 60 years old.
    2. Out of the 9 cases of neuroblastoma, 5 were females and 4 were males.
    3. Histopathologically, neuroblastoma was classified into 3 types of small round cell type (I), polar cell type (II) and nerve cell type (III) .
    4. Out of the 9 cases investigated, 2 were tae type I, 1 was type II, i was type III and the remaining 5 were the mixed type of I and II.
  • 内山 憲正, 鴇沢 正, 牧野 康三, 原 小一, 北 周二, 阿部 瑠美子, 椽尾 貞子, 高木 明
    1960 年 20 巻 6 号 p. 544-548
    発行日: 1960/09/30
    公開日: 2010/11/19
    ジャーナル フリー
    This is a case of 47 years old female who revealed sings of brain tumor for three and half months duration. Autopsy examination disclosed that this is a case of Lindau's tumor located in the right hemiphere of the cerebellum accompanied by focal softening of the cerebrum. Histologic examination revealed that the tumor is an atypical hemangioma and the brain softening might occur due to the circulatory disturbance of the cerebellar hemangioma.
  • 溝口 一枝
    1960 年 20 巻 6 号 p. 549-564
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Studies were made on the duodenum and the ductus choledochus of a total of 125 Japanese. Results of those studies revealed that the opening of ductus hepatopancreatica on the papilla duodeni major by a single hole was recognized in 95.0 ± 2.18%, while that by two holes in 5.0 ± 2.18 %. Mean length of the ductus choledochus was 64.7 mm of which pars intramuralis was 12.4 mm in an average.
    Vater's diverticulum is the termination in common between the ductus choledochus and the ductus pancreaticus major. Those who possess Vater's diverticulum on the joint of the ductus choledochus and the ductus pancreaticus major were 92.0 ± 2.71 % and those who do not possess the diverticulum in spite of the combination of those two ducts were 4.0 ± 1.96 %, while those in which each of the two ducts opens separately on the papilla duodeni major were 4.0 ± 1.96%.
    In inside of Vater's diverticulum, the wall separating the opening of the two ducts presents a form of bicuspid or monocuspid mucous membrane valve closing one side of the opening at a time.
  • 窪田 亮
    1960 年 20 巻 6 号 p. 565-579
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Growth disturbance such as hydrops and deformity produced on the embryos of the embryonating eggs loaded with Nicotine is evidently inhibited by the combined administration of chlorothiazide or Hydrochlorothiazide. While such inhibition was not observed when Trifluoromethyl-hydrothiazide was used in combination with Nicotine.
    Vitamin B12 contents of the allantoic fluid, liver and blood were determined but failed to correlate those findings with the development of hydrops and deformity of the embryos.
  • (特にその組織学的特徴の検討)
    大塚 欣二
    1960 年 20 巻 6 号 p. 580-597
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Out of the total 1, 400 cases of gastrectomy performed in the Second Department of Surgery, Tokyo Uniuersity School of Medicine covering a period of 9 years from 1947 to 1956, macroscopical cases of gastric polyp were 20 and the cases of gastro-polypous cancer were 24. Stated in the followings are the findings of macroscopical and histopathological investigations made on them :
    1. Sexual difference : The rate of gastric polyp between male and female was 10 : 7, while that of polypous cancer was 18 : 6.
    2. Age : The age gpoup of sixties showed the highest incidence rate of both gastric polyp and polypous cancer.
    3. Number : Mean of the number of polyps and cancers per case was 2.1 and 1.3 respectively.
    4. Size : Gastric polyp was mostly in the size of bean, while that of cancer was mostly in the size of pigion's egg.
    5. Form : In both gastric polyp and polypous cancer, they were mostly spherical.
    6. Stem : In both gastric polyp and polypous cancer, nearly half of them possessed stems.
    7. Etat mamelonné : Contrary to our expectation, the rate of its complication was low.
    8: Histopathological characteristics : a. Elevation of the stroma was observed in 100% of both gastric polyp and polypous cancer.
    b. As phenomena frequently observed, there were adenoma, proliferation of superficial epithelium, delation of capillaries, edema, cellular infiltration, encystation, elongation of faveola etc.
    c. As phenomena contrary to our expectation, there were confirmed the defect of covering epithelium and the accompanying cellular infiltration.
    d. Histological picture of the polypous cancer was adenocarcinoma in all cases examined.
    9. The rate of gastric polyp changing into cancer was calculated to be 58.6%. Accordingly, application of gastrectomy in an early stage is considered indispensable whenever polyp is discovered.
  • 内山 憲正
    1960 年 20 巻 6 号 p. 598-607
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    By incomplete ligation of the unilateral renal artery of the rabbit the observation was performed focusing the renal blood flow which is regulated according to the time span from the onset of renal ischemia. The renal circulation at the ischemic state was quite irregularly controlled until 8 hrs from the onset. After that time the blood stream directs principally the juxtamedullary circulation by sacrifying the subcapsular one. The histologic basis for the ischemia of the nephron consists in the axially fibrosis, mesangial edema of the glomerulus and diminishing Altmann's granula and alkaline phosphatase of the tubular epithelium. The experiment of renal ischemia for longer period of time — from 143 hrs on — will be done in further experiment.
  • 神戸川 明
    1960 年 20 巻 6 号 p. 608-634
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    The conditions for optimal determinations from urine of 17-ketosteroids were investigated by various means of each steps of hydrolysis, removal of impurities, extractions and Zimmermann reaction colometry.
    1. Hydrolysis.
    The optimal method for hydrolysis of total contents of 17-ketosteroid as simplified clinical test was acid hot hydrolysis; urine was heated at 100°C for 15 min. with conc·H2SO4 of 1/10 vol. of urine.
    While optimal hydrolysis method for chromatographic separation was acid hot hydrolysis after acid room temperature hydrolysis; urine was shaken at room temperature for 6 days with 50% H2SO4 of 1/10 vol. of urine and equal vol, of ether, the urine was then extracted with ether and the residual urine was heated at 100°C for 15 min. with conc·H2SO4 1/20 vol, of urine.
    2. Removal of impurities.
    The removal impurities in 17-ketosteroid were better Girard keto separation and method by addition of formaldehyde than the other methods.
    The best condition for the two methods were established, and the removal of impurities by addition of formaldehyde could carried out easily as clinical method than Girard keto separation, and it was purified completely as well as Girard.
    3. Extraction.
    The ether was good solvent to extract of 17-ketosteroids in hydrolyzed urine, an concentration of NaOH to removed of impurities was 4 % best.
    4. Colormetry
    The optimal method of colormetry of extracted 17-ketosteroid as followed; 17-ketosteroids in each tubes were added 0.4 ml of 1 % m-dinitrobenzene in ethanol and 0.2 ml of 8 N-KOH aqueous solution, and they were allowed to stand for 30-60 min. at room temperature in dark place and were then added 70% ethanol. The resultant chromogens were readed with the Beckman DU spectrophotometer at 460, 520 and 580 mμ.
    The results were calculated by application of a correction factor according to the principles of Allen.
  • 亀井 利男
    1960 年 20 巻 6 号 p. 635-650
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    In order to bring light on the mechanism of the experimental typhoid infection and the accompanying secondary septicemia and the immunity to them, the mice which received pertussis vaccine intraperitoneally and preparatorily were challenged intraperitoneally with S. enteritidis of varying virulence.
    As a result, it was found that this preparatory inoculation of pertussis vaccine exhibited ann evident defense action against the challenge with a moderately virulent strain of S, enteritidis andd the mice may could tolerate the experimental typhoid infection and the secondary septicemia, while this defense action could not clearly be seen against the challenge with a fully virulent strain of S. enteritidis.
    The serologically nonspecific defense phenomenon observed by the author seems to be different in respect of the mechanism from the prevention by vaccination with attenuated living bacilli of homologous species, because in the former phenomenon the locus where the pertussis vaccine was inoculated exerts an important role in the effect on the challenge organisms and the effect originatedd by the inoculation of pertussis vaccine was demonstrated only for a limited period of time.
    Basing on these observations, the preventive effect on the typhoid infection was analytically discussed from the view point of infection and immunity, and the mechanisms of the typhoid infection and of the immunity to it were revealed to some extent.
  • 笠原 照邦
    1960 年 20 巻 6 号 p. 651-674
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Stated in the following are the findings of the time lapse microcinematographic observationss on the behavior of tissue cultured normal human epidermal cells.
    1. Epidermal cells can move by themselves and occasionally perform emebic movements.
    2. On forming membraneous outgrowth which is characteristic to the epidermal cells, a phenomenon of shaking is observed by the difference in the speed of growth on each part.
    3. Each cell has active movement of undulating membrane and protoplasmic microfibil. This movement was especially evident on the free cells at the periphery of the outgrowth. This movement was especially interesting when a cell tries to catch another cell.
    4. Intercellular bridges, which are the characteristic feature of epidermal cells, were confirmed to be closely related with surface tension aside from the small spines of the cell.
    5. Pinocytosis was observed on the epidermal cells.
    6. Mitochondria were mostly granular and were moving quite actively.
    7. Nnmerous pictures of amitosis were observed, but it was difficult to catch the complete picture of mitosis.
    8. Bubbling phenomena became remarkable before cell division, but this bubbling phenomenon was not always followed by cell division.
  • 桑沢 昭二
    1960 年 20 巻 6 号 p. 675-687
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    General histology, gastric vessels by angiography and the nervous tissues of the linear gastric ulcer were studied.
    As for the clinical and roentogenological observations of the linear gastric ulcer, anthor's colleagues Suzuki and Takematsu have already reported that its characteristic feature is the presence of the atrophy of pyloric sinus aside from the presence of liner ulcer. The purpose of the present study was to investigate the causes of this atrophy of pyoric sinus in addition to the general histological investigations. Findings of the present study was as follows:
    1. Gastris of the pyloric sinus of linear ulcer is extremely sever, but without any characteristics. Thus, it is difficult to attribute this gastritis alone to the cause of the atrophy of pyloric sinus.
    2. Disorders of the vascular system too are difficult to be regarded as the cause of the atrophy of pyloric sinus.
    3. Expecting to obtain some answer, careful histological investigations were made on the nervous system, but the result was negative.
    4. On the contrary, gastric artery and reticular artery were found to have right and left sides, and their distribution from two sides was found to be quite rational phenomenon.
  • 薄井 巖
    1960 年 20 巻 6 号 p. 688-705
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    A unilateral phlenicotomy executed on rabbits causes struma microfollicularis diffusa. This hystological figure corresponds to that of Alpine goiter, a kind of endemic goiter, which can be observed amnng children living in the Alps or in the Himalayan mountain regions.
    In the case goiter developed in this experiment, glandepithel was found to accelerate functionally, while the constant consumption of colloid substance, which gave prolif erous phase in the process, did not allow the substance to be accumulated in follicles, and after nine month extensive study it was generally demonstrated that there remained no observable amount of the substance in follicles. Twelve months later, however, the beginning of re-accumulation process of colloid substance was observed, follicles begining to grow larger, and fibers of connective tissue to increase between each gland and in interstice. Thus, struma diffusa can be considered to suggest that it develops into struma colloidaris diffusa.
    In conclusion it can therefore be held that dyspnea and hypoxia caused by a unilateral phlenicotomy played an important part in developing goiter in the subject experimentation.
  • 宮下 美生
    1960 年 20 巻 6 号 p. 706-731
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Pyloric motility was observed and analysed by the use of consecutive photography with gastrocamera on 72 patients. Follow-ups made after Schindler's gastrocopic classification (1928) revealed 19.4% of type I, 34.7% type II, 12.5% of their intermediate type and 2.8% of type III. In addition, it was considered quite proper to add another abnormal type of type IV which was recognized in 30.6%.
    On comparison of the types of pyloric motility and clinical symptoms, they were found to have parallel relationship. Histologically, it was confirmed that the abnormality of pyloric functions is based on the organic factors of the pyloric ring.
    On an understanding that pyloric insufficiency is the pylorus commonly having a certain grade of opening without the picture of complete closure, it was further subdivided into two kinds of simple pyloric insufficiency (P.I, type) and stenotic insufficiency (S.I. type) . And, investigations were made on the relationship between those two types of insufficiency and the types of motility as well as histological findings for the observation of the relationship existing between pyloric insufficiency and pyloric functions.
  • 溝口 一枝, 長田 勘吉良, 栗原 稔雄
    1960 年 20 巻 6 号 p. 732-737
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
    Pars intramuralis of the ductus choledochus was studied on a total of 46 Japanese. On having detailed investigations of its length, size, relationship to the ductus pancereaticus major and that to the formation of Vater's diverticulum, the authors pointed out the difference in the locality of Vater's diverticulum from the one stated in the text books hitherto published.
  • 中村 重道, 荻野 幸雄, 市原 正雄, 小松 晃, 国府 田中, 成沢 達郎, 井上 康平, 遠山 啓一郎, 中川 良平, 杉田 幸二郎, ...
    1960 年 20 巻 6 号 p. 738-739
    発行日: 1960/09/30
    公開日: 2010/09/09
    ジャーナル フリー
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