昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
28 巻 , 3 号
選択された号の論文の9件中1~9を表示しています
  • 田中 治男
    1968 年 28 巻 3 号 p. 131-143
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    In an attempt to pursue the disturbances of longitudial growth of long bones, the impacts were continuously given to the head of the femur in young rabbit and studied histochemically the consequent change of the epiphyseal cartilage with time.
    Results.
    1. A reduction in the length of the bone became appreciable towards the 15th week, while premature closure of the epiphyseal line was demonstrable at the 31st week.
    2. The glycogen content was found to be reduced at the 5th week or later.
    3. The content of acid mucopolysaccharide also began to decrease later than the 5th week, and this reduction is probably responsible for disturbance of calcification and consequently of growth.
    4. It may be thus concluded that the impacts given to the epiphyseal cartilage in a continuous manner has resulted in disturbance of glycometabolism in the resting cartilaginous layer toward the 5th week and consequently in disturbed growth of cartilage cells, eventually leading to disturbance of bone growth.
  • 福島 実
    1968 年 28 巻 3 号 p. 144-151
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    In the present experiment, naphthalene, which is known as a methemoglobin forming substance, was administerated to rabbits by oral application under two feeding ways of standard and V. C deficient food and by intraperitoneal and subcutaneous injection.
    The spleens of these rabbits were then examined histologically and the following results were obtained.
    1) In the oral administration group (1.0g/kg), the rabbits fed with V. C deficient food through intragastric infusion for a long term showed edema of capsule, atrophy and rarefaction of follicles, fibrous proliferation, thickening of sinus wall and swelling of sinus endothelium. These changes were more remarkable than those fed with standard food.
    In the group fed for a short term under the same condition, these changes were only slight, but a similar relation between both breeding ways was observed.
    2) Subcutaneous injection (1.0g/kg) for a long term resulted in, thickening of capsule, atrophy of lymph follicles, peri-and intraf ollicular edema and liquefaction, proliferation of reticulum cells, vacuolization of the nuclei, thickening of sinus wall, and edema and necrosis of red pulp of a marked degree.
    3) In the naphthalene poisoning, liquef active necrosis occured from exudation to the surrounding area of peripheral arterioles of pulpa, sinus wall and intrafollicular vessels due to acceleration of permeability resulting from hypoxemia.
  • 小泉 勝司, 井原 正剛
    1968 年 28 巻 3 号 p. 152-155
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    Comparative anatomy of various sorts of the triangles formed by cranial curvature and hypophyseal point on the cranial median section of the Cynomolgus monkey was studied craniometrically.
    The following conclusions were obtained.
    1. In ΔAPB of the Cynomolgus monkey, ∠APB and ∠PBA showed the intermediates of the respective angles of the Orang-Utan and the Chimpanzee, and ∠PAB showed those of the Macacus fuscatus (Blyth) and the Gibbon.
    2. In ΔAPN, ∠PNA and ∠APN showed the intermediates of the respective angles of the Macacus fuscatus and the Gorilla, and L PAN showed those of the former and the Gibbon.
    3. The three angles of LANB lay between those of the Gorilla and the human being.
    4. The three angles of LPNB lay between those of the Macacus f uscatus and the Orang-Utan.
    5. The hypophyseal triangles of the Cynomolgus monkey generally seemed to resemble to those of the Orang-Utan and the Chimpanzee more respectively than those of other animals.
  • 新居 昭, 雨宮 久雄, 生田目 英一, 清水 範之, 西島 樹郎, 新居 美都子
    1968 年 28 巻 3 号 p. 156-161
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    Nivaline is an alkaloid extracted from Galanthus nivalis L. and chemically, the same as Galanthamine. Nivaline showed potent anti-cholinesterase activity and used for a remedy of the treatment of myoparalysis clinically, such cases as poliomyelitis and myasthenia gravis etc.
    We have studied the relationship between the anti-cholinesterase activity and the effect of Nivaline as a remedy of the treatment of poliomyelitis. The following results were obtained.
    1) Cholinesterase (ChE) activity in blood of patients suffering from acute anterior poliomyelitis following the administration of 0.25 mg, 0.5mg and 2.5mg of Nivaline is almost the same as the control.
    2) In vitro, 10-4-10-5 M of Nivaline inhibited 50% of the specific and non-specific ChE activity.
    3) ChE activity in brain and in liver of rat and mouse following the administration of Nivaline is almost the same as the control.
  • 川上 勝久
    1968 年 28 巻 3 号 p. 162-171
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    It was not until the last decade that the biochemical composition of muscles has been actively investigated. In order to know a morbid state of muscles more thoroughly, the authers carried out an animal experiment, in which the level of Na, K, mucoprotein, alkaline and acid phosphatase in the serum as well as the water content and enzymatic activities (alkaline and acid phosphatase, creatinekinase and succinic dehydrogenase) of the gastrocnemius were serially determined in animals who were preliminarily subjected to ischiatic neurotomy, fixation with Plaster cast or ligation of both the femoral vein and lymphatic vessels unilaterally to prepare morbid muscle preparations in situ.
    The folloving results were obtained :
    Ischiatic neurotomy was followed by a slight increase in Na, slight decrease in K, increase in the serum mucoprotein and acid phosphatase, marked increase in the muscle acid phosphatase as well as marked decrease in creatinekinase and succinic dehydrogenase activities.
    After the fixation with Plaster cast there were slightly elevated Na, slightly lowered K, increased mucoprotein, and reduced creatinekinase and succinic dehydrogenase activities were noted.
    With the ligation of the femoral vein and lymphatic vessels all these biological values, after the initial alteration, returned to normal range by the 2nd to 3rd week.
    Thus, there was a difference in response to these procedures noted between mucoprotein, acid phosphatase, creatinekinase and succinic dehydrogenase.
  • 村田 道治
    1968 年 28 巻 3 号 p. 172-186
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    Piperazinylalkyl-phenothiazine誘導体に属するPerphenazineの鶏胎仔に及ぼす影響を一般発育, 奇形の有無, 肝臓並びに腎臓の病理組織学的所見から吟味し, さらに既往の向精神薬と抗ヒスタミン剤に関する業績と構造―活性相関の面から比較検討した.
  • 會 瑞彦, 高橋 敬蔵, 川澄 正一, 細山田 田明義, 佐伯 志明, 鄭 彰雄, 伊藤 啓之助, 川上 〓市, 早川 聿郎, 美濃部 嶢
    1968 年 28 巻 3 号 p. 187-190
    発行日: 1968/03/28
    公開日: 2010/11/19
    ジャーナル フリー
    Two cases of acute pulmonary edema during genaral anesthesia with G-O-F (N2O: O2: Halothane) inhalation were presented in this report.
    Case I: A 20-year-old male was operated upon with diagnosis of spondylolysis of the fifth lumbar vertebra. Acute pulmonary edema was caused by airway obstruction due to the cuff trouble of endotracheal tube during general anesthsia.
    Case II: A 49-year-old female underwent radical hsterectomy with diagnosis of uterine cancer. Acute pulmonary edema was caused by probably overhydration.
    Etiology, symptoms, diagnosis, treatment and prognosis of acute pulmonary edema during genaral anesthesia were discussed with reference to literatures.
  • 清水 盈行, 丸山 善啓, 北条 稔, 大谷 利昭, 安藤 正英, 上野 輝喜, 山田 栄八郎, 矢崎 甲代治, 藤崎 裕, 土持 喬, 酒 ...
    1968 年 28 巻 3 号 p. 191-200
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    昭和大学第2内科に入院した過去10年間の白血病患者48名について臨床的に分析検討した.
    年度別患者数は1963年から増加し, 年齢別分布では20歳~24歳にpeakがあった.病型分類では急性白血病70.8%で最も多く, 次いで慢性骨髄性白血病の27.2%であつた.
    初発症状および主訴は全身倦怠感, 発熱, 出血が急性白血病, 慢性骨髄性白血病とも多く, 慢性骨髄性白血病ではこの他に腹部腫瘤, 腹部膨満感などが特徴的であつた.
    臨床所見では慢性骨髄白血病で大きな脾腫を約半数の患者に触知したが, 全く触知しなかった症例も全体の1/3を占めていた.
    血液所見では急性白血病で著明な貧血, 血小板数の著しい減少, 出血時間延長およびRumpe-Leede氏現象の強陽性を示す症例が多かつたが, 慢性骨髄性白血病では中等度の貧血で, 一般に急性白血病より軽度の所見を示した.
    白血球数は急性白血病では1×104以下の症例が58.9%で, 慢性骨髄白血病では10×104~20×104の症例が多かった.
    急性白血病症例の25.1%が91%以上の末梢中えの白血病細胞の出現率を示したが, 22%の症例は10%以下の出現率であった.慢性骨髄性白血病では69.2%の症例が31~60%の出現率を示した.
    急性白血病の骨髄の白血病細胞は11%~91%以上にわたり広く分布していた.
    急性白血病の白血球数, 未梢血の白血病細胞, 骨髄の白血病細胞および生存期間の間にはあまり相関性を認めなかつたが, 白血球数が多く, 未梢血, 骨髄ともに白血病細胞の多い症例では生存期間の短縮が認められた.
    急性白血病の最近10年間の50%生存期間は4.5カ月最近5年間では5.5カ月であつた.治療法により比較するとSH単独3.3カ月, 6MP.SH併用5.6カ月, 6MP.SH.その他併用8.2カ月であったが, もつと症例を増して検討する必要がある.
    急性白血病の初診時血清ceruloplasminの高値を示す症例は比較的生存期間が長く, 40mg/dl以上を示す症例では50%生存期間が9.6カ月と延長していた.また死亡末期にはどの症例もceruloplasminの低下が認められ急性白血病の治療においてceruloplasminを測定することの意義について述べた.
  • 入江 邦夫, 岡松 孝男, 飯島 恒司, 藤井 元夫, 高山 宏夫, 栗原 正明, 土岐 秀典, 太田 秀男, 高場 利博, 中田 幸之介
    1968 年 28 巻 3 号 p. 201-203
    発行日: 1968/03/28
    公開日: 2010/09/09
    ジャーナル フリー
    Stastical observations of the children with inguinal hernia in our clinic were studied.
    The total cases operated for inguinal hernia under 15-year-old children were 320 in number. The case were divided into 2 groups: the Ist group which included the cases treated from 1960 to 1963 was 126 and the 2nd, from 1964 to 1967, 194 in number. Comparing between the 2 groups, the operative course were both smooth, the postoperative results were the same on the both groups, the mortality was none and the average age of the 2nd group was younger than that of the Ist group.
    We suppose that the surgical treatment for inguinal hernia should be done in infant in future.
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