Carnosineおよびそのメチール化合体であるAnserine, Ophidineの薬理作用については教室の研究があるが, これらDipeptideの母体であるHistidineの冷血動物心臓におよぼす影響を検討したものは意外に少い.
本研究はL-Histidine (L-His) , Histamine (H) とそのアセチール化合体であるN-Acetylhistidine (N-A-his) とN-Acetylhistamine (N-A-h) の冷血動物心臓における作用を検討したものである.Bufo vulgarisとRana catesbianaの剔出心臓について実験を行った.
1) N-A-his, NA-hの合成はBergmann, vander Merweらの方法により行ったが, 精製過程でイオン交換樹脂を使用して, 改変を加えた.両物質とも再結晶をくりかえし, 純粋度を確認した後実験に供した.
2) L-Hisの高濃度で振幅の増強がみられる.しかし律動数は各濃度で影響を受けない.これに反し, N-A-hisは振幅をBufo, Ranaの何れでも減弱した.冷血動物心臓に関してはL-HisとN-A-hisとは互に相反する作用を現わす.
3) H, N-A-hは高濃度で振幅を増強する.L-His, N-A-hisとは相違して, 両者の作用は類似している
4) Adrenaline, Acetylcholine, Dihydroergotamine, Atropine, 塩化Barium, 亜硝酸ソーダ等との併用実験からみて, L-HisとN-A-hisは心筋の特殊受容体には直接作用しないもののようである.他方H, N-A-hは心筋を直接侵襲するものと思われる.
5) HはDiphenhydramineによって拮抗される.しかしN-A-hは拮抗されない.Procaineの場合にも同様なことが観察される.したがってHの場合にもアセチール基の存在はある特定の意義を有するもののようである.
6) H作用はL-Hisの前処置によって抑制されるが, N-A-hの作用はL-HisによってもN-A-hisによっても抑制されない.この点からもアセチール基の存在はL-HisおよびH作用に対し微妙な影響をおよぼすものであることが明らかになった.

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With a view to unvail the substance of staphylococcal infections and the responses on the part of a living body, 101 healthy children (from neonatal period to 15 years of age olds) and 28 healthy adults (over 16 years old) were studied for the measurement of antibody value of seven kinds of Coagulase contained in serum, mother's serum, umbilical cord serum and breast milk. Coagulase is supposed to be one of the antibodies of staphylococcal infections.
The experiment revealed the following results:
1) Observed from the viewpoint of age, the antibody value of Coagulase is highest among newborn babies, and it gradually goes down as months pass reaching lowest when the babies are from five to twelve months old.
2) Cases of negative phase in antibody production are fewest among 16-20 years old group (0 %), 11.8 percent among 11-15 years olds, 23.8 percent among upward of 20, 31.3 percent among 4-6 years olds, 55.5 percent among 1-3, and 85.7 percent among from nine to twelve months old babies. In general the, younger the person is, the more cases of negative phase in antibody production.
3) Coagulase antibody contains the highest percentage of Coagulase type V (27.9 %) and the lowest percentage of type I (6.95 %) . It was found that Coagulase antibody varies according to the types of Coagulase.
4) As to the relations between respective groups of Phage and content percentage of respective types of Coagulase antibody, Phage type III contains the highest percentage of Coagulase antibody (72.1 %), and Phage type I showed a low percentage (24.8 %) .
5) The investigation of frequency of staphylococcal invasion reveald that Coagulase antibody No. 1 is a principal invader (30.3 %) and that the older the person grows, the more types of Coagulase antibody and more frequent staphylococcal invasions are noted.
6) The experiment revealed that respective groups of Phage showed higher Coagulase antibody titer with the increase of age.
7) The experiments of 20 species of mother's blood, umbilical cord blood and breast milk revealed that the antibody titer of Coagulase was highest in mother's blood and that of umbilical cord blood is approximately 1/2.4 of that of the former, while breast milk showed approximately one-thirthieth of the antibody titer of mother's blood and umbilical cord blood showed about one-eleventh.
8) The high titer of Coagulase antibody in infancy is supposed to be resultant from the infants' receiving their blood from mother's blood and her umbilical cord blood which show high titer of Coagulase antibody.
9) The distribution of antibody of all type of Coagulase in mother's blood, umbilical cord blood and breast milk showed no evident difference from that of normal persons.

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