昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
34 巻, 6 号
選択された号の論文の5件中1~5を表示しています
  • 菅沼 明人
    1974 年 34 巻 6 号 p. 539-555
    発行日: 1974/12/28
    公開日: 2010/09/09
    ジャーナル フリー
    This study was conducted for the past 8 years on 14 cases with clinical diagnosis of chronic renal failure (CRF) and 8 cases of acute renal failure (ARF) not receiving hemodialysis and peritoneal perfusion.
    1. In cases of CRF, disappearance of cross-striation (hyaline Querbänder), necrosis and small scar were noted in 43%. In casese of ARF, disappearance of cross-striation were noted in 75% and coagulative necrosis in 25%. The change of stainability of muscle fiber was noted in both groups of renal failure.
    2. Among histological findings of small arteries and arterioles, sclerotic changes such as fibrous intimal thickening were noted in 86% of CRF, while fibrous hyalinoid thickening in 29%. In cases of ARF, hydropic-like changes such as vacuolization and porotic changes of the vessel wall were noted in 88% each, and partial fragmentation and disappearence of elastic fiber in 57%.
    3. As to interstitial changes, perivascular fibrosis was seen in 57% of cases of CRF, and appearance of fibrils among myocardium in 43%. Marked interstitial edema was seen in all cases of ARF.
    In renal failure, the kidney has a great influence on the heart and the correlation between the two organs is quite intimate, as an important factor in the progress of disease in the organism.
  • 月岡 きね子
    1974 年 34 巻 6 号 p. 557-565
    発行日: 1974/12/28
    公開日: 2010/09/09
    ジャーナル フリー
    1) A combined preparation containing o-ethoxybenzamide (EB) +3-hydroxy-p-butyro-phenetidide (HPBP) as principal ingredients proved to be more effective in relieving pain than that containing acetylsalicylic acid as its principal ingredient, whereas the latter preparation was found to be superior in antipyretic efficacy.
    2) Synergistic analgesic effect was evident following administration of EB+HPBP combined with aluminum acetylsalicylate, the synergism being essentially potentiation rather than summation.
    3) The analgesic-antipyretic effect of aminopyrine was noted to be enhanced by concomitant administration of taurine. Such enhancement of the effect of aminopyrine was moreover marked when 3-aminopropanesulfonic acid (homotaurine) was combined with it, while combined 1-amino-2-hydroxypropanesulf onic acid (AHPS) and aminopyrine produced an enhanced effect only comparable to that observed with the aminopyrine-taurine combination.
    4) A similar augmentative trend of drug action was observed with combinations of analgesic-antipyretic drug and ω-aminocarboxylic acid (γ-aminobutyric acid or γ-amino-β-hydroxybutyric acid) .
    5) ω-Aminosulf onic acid proved to be capable of facilitating absorption of aminopyrine from the gastrointestinal tract. The following interrelationship was noted to exist among the three compounds as to degree of their augmentative effect on the analgesic action of drugs :
    homotaurine > taurine≥AHPS
  • ―特に造影能力, およびその腎機能との関連性, ならびにその安全性について―
    松井 恒雄
    1974 年 34 巻 6 号 p. 567-599
    発行日: 1974/12/28
    公開日: 2010/09/09
    ジャーナル フリー
    The study was mainly concerned with the contrasting capacity of Drip Infusion Pyelography (hereinafter referred to as D.I.P.), the relationship between the cleareness of picture and renal function, and the effects on the human body.
    1. The examination of its contrasting capacity.
    As the result of the study on the method of the premedication and the use on the contrast media in order to obtain a clearer picture, it was proved that rentgenological photographing with the use of the contrast media gave a clear picture, without restricting food and drink on the previous night of the photographing, and that the contrast media need not be diluted.
    The examination under these conditions showed that in 88.2% of the normal functioning kidneys D.I.P. was as effective as Retrograde Pyelography and in 53.3% of the dysfunctioning kidneys it worked as well.
    2. The relationship between the contrasting capacity and renal function.
    The excretory quantity of uro-iodine and the clearness of the D.I.P. pictures were paralleled and observed in order to find out whether they were proportioned to each other. As the result it was shown that the contrast of the pictures could become an indication for the renal function in the slightly dysfunctioned kidneys, while it did not apply in the seriously dysfunctioned kidneys because the contrast was not proportioned to the excretory quantity of iodine in some cases.
    3. Safety of D.I.P..
    With a view to observing what effect a large quantity of iodine (which is used in executing D.I.P.) gives on the human body, the examination on the values of blood urea nitrogen and creatinin before and after D.I.P. revealed that the former was liable to rise but was normalized after 168 hours, and the latter had not change. In order to support the above result, an animal experiment was carried out to seen the effects of the use of a large quantity of the contrast media. The experiment showed that there was no histological findings in the liver or the adrenal gland, but in the kidneys there were a dilatation of partial glomerular capillary, a hyalinosis of renal tubule's epithelium and hyalincylinder. All the changes, however, were normalized after 168 hours. Hence, it was presumed that the changes were reversible and were temporary vital reactions.
  • 矢代 昭夫
    1974 年 34 巻 6 号 p. 601-626
    発行日: 1974/12/28
    公開日: 2010/09/09
    ジャーナル フリー
    Electronmicroscopic study was carried out on the skin tumors of mouse treated with 20-methylcholanthrene (20 MC) and 4-nitroquinoline-N-oxide (4NQO) in order to elucidate the mechanism of tumorgenesis.
    The results obtained were as follows ;
    1) Intramitochondrial electron dense bodies were observed in the prickle cells of the animals treated with 20 MC on two months and after two months. The mitochondria containing these bodies were swollen and enlarged.
    However, these bodies were not found in the 4 NQO-treated animals in spite that the degenerated change of mitochondria was seen.
    2) The formation of the crown of thorn-like pattern, as described by Setälä, was observed in epidermal cells after three months' treatment with 20 MC and 4 NQO.
    3) After 4 months' treatment with 4 NQO, two kinds of cells, i.e. clear and dark cells, were found in proliferating epidermal cells in addition to the changes of tonofilament mentioned above. However, both cells may rather be taken as an ultrastructural sign of degeneartion.
    4) The finding observed above suggested to be precancerous changes of the epidermis. However, after 6 months' treatment with 4 NQO, the finding was almost disappeared and fibrosarcomatous change was developed. It was assumed that electron microscopic examination proved the specific tissue affinity of 4 NQO, as reported by Nakahara.
    5) The spinalioma cells showed an increase of nuleo-cytoplasmic ratio, the irregularity nuclear shape together with an increase in volume and number of nucleoli. Although cytoplasmic organelles were generally numerous in the carcinomatious cells, tonofilaments and desmosomes were smaller in number than in normal epidermal cells.
    6) The fibrosarcoma cells showed the irregularity of intrachromatic granules and the variety of nucleoli. The cytoplasmic filamentous structures were found in the majority of the tumor cells. They were delicate and slightly wavy in appearance. It was assumed that they were related to the collagen production.
  • 太田 秀典, 副島 和彦, 孫 邦松, 神田 実喜男
    1974 年 34 巻 6 号 p. 627-632
    発行日: 1974/12/28
    公開日: 2010/09/09
    ジャーナル フリー
    A 72-years old, male patient was dead on the diagnosis of the pneumonia. An autopsy, we had noticed the carcinoma of the right lung and there was metastasis of the right hilar lymph nodes.
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