IgG, IgM, anti-BSA-IgG and anti-BSA-IgM were measured by the immunodifusion technique. Serum titers of antibody as a whole was measured by the hemagglutination technique. (1) Primary response: Prednisolone or 6-MP was administered simultaneously with the 1st immunization of BSA. The quantity of IgG was also lower in both of the 6-MP and prednisolone groups compared with the control group, and its reduction was larger in the 6-MP group than the prednisolone group. There were no differenced in IgM among the three groups. The hemagglutination titers were lower in both groups compared with the control group. The grade of reduction was larger in 6-MP group. (2) Secondary response. In this case also prednisolone or 6-MP administered simultaneously with the 2nd immunization of BSA. There were no differenced in the hemagglutination among three groups. No change of serum IgG was observed in the prednisolone group, but it was slightly lower in the 6-MP group. IgM showed a similar tendency with IgG in the three groups. (3) The effects of continuous administration of the drugs on the 2nd immunization were examined. IgG gradually decreased by the administration of prednisolone, and showed a tendency of increase by its discontinuance. In the 6-MP treated group, it slightly decreased. IgM also decreased in both of the prednisolone and 6-MP groups. Anti-BSA-IgG increased slightly 7 to 12 days after the immunization and was kept at the same level in the control group. In the prednisolone group, anti-BSA-IgG slightly decreased, while it decreased markedly in the 6-MP group.
A series of 250 cases undergoing Cesarean section under spinal anesthesia were presented and analyzed from the clinical points of view. Hypotension down to 80 mmHg or less occured in 43.6% of all cases following spinal anesthesia, and the incidence of hypotension was closely related to the level of sensory analgesia (initial level) . Hypotension could be mostly restored by changing the position from supine to lateral, but the effects of vasopressor was not uniform. It was seen that the amount of rapid intravenous infusion was influenced by the duration and degree of hypotension. Associated with anesthesia, Apgar' Score was indicateed 7 to 10 points in 96% of all cases. Administration of Droperidol, Diazepam and Pentazocine were effectively choiced for any visceral pain after birth and any emesis.
The activities of glutamate dehydrogenase (EC: 22.214.171.124; GMD) in sera from 57 healthy person and 869 patients suffering from various diseases who had been obtained one or more abnomal results in GOT, GPT, LDH, TTT, ZTT, and CCLF values were investigated. Conclusions are as follows : 1. Normal range of serum GMD levels is 0-1.4 U/l (average ; 0.4 U/l) . 2. Average level obtained from patients is 3.17U/l. GMD activities obtained from serum hepatitis, alcoholic hepatitis, chronic hepatitis, jaundice, and hemo-dialysis are significantly higher than those from other diseases. 3. The correlation coefficient between levels of GMD and LDH, TTT is generally lower than that between GMD and GOT, GPT in all cases. 4. The fluctuation of activities of GMD in serum is closly coincident with the process of clinical findings in serum hepatitis, but in contrary, in acute hepatitis it is observed many cases that GMD level does not or only little change during the higher elevation of other enzyme activities.
The author studied the adequate flow rate of fresh gas to Jackson-Rees circuit to obtain normal arterial carbon dioxide tension (Paco2) in clinical pediatric anesthesia. The problem, whether the controlled respiration with large tidal volume and low respiratory rate was appropriate or not, was investigated with blood gas study and also hemodynamicaly in clinical cases and adult mongrel dogs. The following results were obtained. 1. In children aged from 3 months to 5 years old, 220 ml/kg/min of fresh gas flow to Jackson-Rees circuit showed invariably more normal Paco2 than the cases with 31/min of fresh gas flow. 2. In the similar cases, the controlled respiration with large tidal volume (20 ml/kg) and low respiratory rate (20/min) showed more normal Paco2 and higher arterial oxygen tension than those with smaller tidal volume (10 ml/kg) and high respiratory rate (40/min) . 3. In the dogs, the controlled respiration with large tidal volume and low respiratory rate showed larger alveolar ventilation, larger fall of mean arterial pressure, smaller rise of pulmonary arterial pressure and smaller increase of cardiac output than those with small tidal volume and high respiratory rate. From above results, the author concluded that 220 ml/kg/min of fresh gas flow to Jackson-Rees circuit was sufficient to guarantee the adequate CO2 washout from the body, and the controlled respiration with large tidal volume and low respiratory rate was satisfactory from the viewpoint of gas exchange and hemodynamics.
The thickness of the hypodermic fatty layer was measured in 45 infants (20 males, 25 females) . The measurements were taken from 36 different points of the body on the 3rd day and the 6th day after birth. The results were examined for difference in thickness between the 3rd day and the 6th day in both sexes and for the relationship of such difference with : the physiological decrease of body weight of the infants, the thickness of the hypodermic fatty layers of the respective mothers, and the delivery frequency and age of the mothers. 1) The distribution pattern of the thickness of the hypodermic fatty layer in infants was the same as the pattern in older individuals, but the disparities between the thicker parts and the thinner parts were smaller than those of the older subjects. 2) The thickness on the 6th day showed a tendency to be greater than that on the 3rd day in both sexes ; this tendency was more evident in males than in females. 3) Comparing the differences in relation to sex, they tended to be larger in all the anterior parts of the upper extremities, the posterior parts of the upper arm and the anterior trunk around the navel in males, and in the hips and the posterior parts of the lower extremities in females. 4) Thickness increase between the 3rd and 6th days tended to be limited to the anterior surface of the arm for infants gaining 101 to 150 gm., and to be generally distributed throughout all parts of the body for those gaining more than 150 gm. 5) The children of mothers who had thicker hypodermic fatty layers, and were multiparous, and aged, had thicker hypodermic fatty layers than the other children.
We reported a case of uachal cacinoma with a bladder stone in a 66-year-old man. Patient was admitted to the hospital with gross hematuria and pain on urination on December 21, 1964. Cystoscopic examination revealed a bread basic tumor of a thumb tip size in the dome of the bladder. After the lithotripsy of a bladder stone, partial resection of the bladder including the urachal canal was performed on January 18, 1965. Histological findings of tumor were mucus-secreting adenocarcinoma. 4500 rads of Co60 was given after the operation. As finding the recurrent tumors of rice size in the same part of the bladder, the transurethralelectrocoagulation was done on April 26, 1965. During the course, anuria was occured and right nephrostomy was done on October 4, 1965. He died of the intestinal obstraction on November 7, 1965. Autopsy revealed multiple metastases, lungs and retroperitoneal lymphnodes, and intraperitoneal spread. Twenty five cases of urachal carcinoma were collected from the Japanese literature between 1971 and 1974 and clinical and pathological features of this disease were discussed.
A 43-year-old female with ileus received resection of small intestine, and a 52-yearold male with bleeding gastric ulcer received gastrectomy. Both patients were operated at emergency situation under general anesthesia in a small private hospital. They had apparently smooth courses until the fifth postopertive day, when we found complete atelectasis of the left lung on chest X-ray films. Because no bronchoscopes were available at that time, we treated the atelectases with following rather simple measures and fortunately obtained exellent effects. At first balloon inflations were used in each case, and were satisfactory with this measures alone in the latter case. In the former case, bronchial lavage under endotracheal intubation followed by vibration of chest wall brought satisfactory result.
A case of Hallermann-Streiff Syndrome with congenital bowing deformity of radius was reported. The patient was a male child of 40 days of age and was showing rare 2 negative signs (congenital bowing deformity of Radius and mental retardation) according to Francois, excepting chief feature. The chief clinical findings consisted of bird like face, hypotrichosis, atrophy of skin, congenital cataract, microphthalmia, nanism and above-mentioned negative sign. Cytogentic study used chromosomal analysis was normal.